This website supplements our publication "Connecting genetic risk to disease endpoints through the human blood plasma proteome".
In our study, we performed a genome-wide association study with protein levels (pGWAS). Using a highly multiplexed, aptamer-based, affinity proteomics platform (SOMAscan™), we quantified levels of 1,124 proteins in blood plasma samples from 1,000 German individuals (KORA cohort) and 338 Arab or Asian individuals (QMDiab cohort).
We identified 539 independent, genome-wide significant SNP-to-protein associations, which can be investigated using this webserver.
The manuscript accompanying this website was published in Nature Communications:
Suhre K et al., Connecting genetic risk to disease endpoints through the human blood plasma proteome. Nature Communications (2017); doi:10.1038/ncomms14357
A preprint (not peer-reviewed) version of the manuscript is available at bioRxiv (doi:10.1101/086793)
This website is a joint project of the Institute of Bioinformatics and Systems Biology (IBIS) at the Helmholtz Zentrum München and the Bioinformatics Core Facility at the Weill Cornell Medical College in Qatar.
It was developed and is being maintained by Matthias Arnold and Johannes Raffler, both members of the IBIS Metabolomics group.
Please feel free to contact us if you have any questions regarding the contents of this site.