HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 131

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Angiogenin cis Discovery rs17114699 14:21,158,910 G/T 0.10 995 0.753 0.064 7.3×10-30 1.180 1.3×10-26 3.1×10-22

 

Regional association plots

 

Boxplots and histograms for top associations

Angiogenin

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Angiogenin

Target (abbrv.) Angiogenin
Target (full name) Angiogenin
Somalogic ID (Sequence ID) SL000003 (4874-3_1)
Entrez Gene Symbol ANG
UniProt ID P03950
UniProt Comment
  • Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Biomarker applications (based on IPA annotation)
  • response to therapy

All locus annotations are based on the sentinel SNP (rs17114699).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
eQTL genes
  • RNASE9 ribonuclease, RNase A family, 9 (non-active)

 

Results from other genome-wide association studies

No associations available.