HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 133

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Lysozyme cis Discovery rs1800973 12:69,744,014 C/A 0.07 995 0.953 0.082 2.4×10-29 1.140 1.2×10-28 8.8×10-31

 

Regional association plots

 

Boxplots and histograms for top associations

Lysozyme C (Lysozyme)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Lysozyme C (Lysozyme)

Target (abbrv.) Lysozyme
Target (full name) Lysozyme C
Somalogic ID (Sequence ID) SL000510 (4920-10_1)
Entrez Gene Symbol LYZ
UniProt ID P61626
UniProt Comment
  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Biomarker applications (based on IPA annotation)
  • unspecified application
Pathway Interaction Database
  • C-MYB transcription factor network
Reactome
  • Amyloids

All locus annotations are based on the sentinel SNP (rs1800973) and 1 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes

 

Results from other genome-wide association studies

Trait P Study Source
Alcohol dependence 2.8×10-7 19581569 (PMID) GRASP2 nonQTL