HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 143

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-5 Ra cis Discovery rs2290610 3:3,139,957 T/C 0.36 994 0.489 0.043 7.6×10-28 1.170 2.3×10-27 7.8×10-22
IL-5 Ra cis Replication rs2290610 3:3,139,957 G/A 0.50 337 -0.344 0.064 1.8×10-7 -1.170 2.3×10-7 2.6×10-6

 

Regional association plots

Interleukin-5 receptor subunit alpha (IL-5 Ra)

 

Boxplots and histograms for top associations

Interleukin-5 receptor subunit alpha (IL-5 Ra)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-5 receptor subunit alpha (IL-5 Ra)

Target (abbrv.) IL-5 Ra
Target (full name) Interleukin-5 receptor subunit alpha
Somalogic ID (Sequence ID) SL005188 (4491-4_2)
Entrez Gene Symbol IL5RA
UniProt ID Q01344
UniProt Comment
  • This is the receptor for interleukin-5. The alpha chain binds to IL5.
Wiki Pathways
  • IL-3 Signaling Pathway
  • IL-5 signaling pathway
  • Inflammatory Response Pathway
Pathway Interaction Database
  • IL5-mediated signaling events
Reactome
  • G beta:gamma signalling through PI3Kgamma
  • GPVI-mediated activation cascade
  • Interleukin receptor SHC signaling
  • Interleukin-3, 5 and GM-CSF signaling
Pathway Studio
  • IL5R → SOX4 signaling
  • IL5R → STAT signaling

All locus annotations are based on the sentinel SNP (rs2290610) and 5 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (1-methylxanthine)/(homostachydrine*) 2.8×10-4 21886157 (PMID) GRASP2 metabQTL