HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 162

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CDON cis Discovery rs3740909 11:125,889,526 C/T 0.07 993 -0.829 0.078 4.4×10-25 -1.170 7.7×10-26 6.6×10-21
CDON cis Replication rs3740909 11:125,889,526 G/A 0.11 337 -0.542 0.100 1.1×10-7 -1.160 1.4×10-8 5.9×10-7

 

Regional association plots

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

 

Boxplots and histograms for top associations

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

Target (abbrv.) CDON
Target (full name) Cell adhesion molecule-related/down-regulated by oncogenes
Somalogic ID (Sequence ID) SL014092 (4541-49_2)
Entrez Gene Symbol CDON
UniProt ID Q4KMG0
UniProt Comment
  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
Pathway Interaction Database
  • Signaling events mediated by the Hedgehog family
Reactome
  • CDO in myogenesis
  • Ligand-receptor interactions

All locus annotations are based on the sentinel SNP (rs3740909) and 42 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CDON cell adhesion associated, oncogene regulated

 

Results from other genome-wide association studies

Trait P Study Source
Chronic lymphocytic leukemia/small lymphocytic lymphoma 2.2×10-5 20639881 (PMID) GRASP2 nonQTL
cg07498426 (chr11:125952718) 2.9×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs