HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 187

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IP-10 cis Discovery rs11548618 4:76,943,947 G/A 0.01 997 1.841 0.191 4.9×10-21 2.790 7.2×10-36 1.4×10-4

 

Regional association plots

 

Boxplots and histograms for top associations

C-X-C motif chemokine 10 (IP-10)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-X-C motif chemokine 10 (IP-10)

Target (abbrv.) IP-10
Target (full name) C-X-C motif chemokine 10
Somalogic ID (Sequence ID) SL003183 (4141-79_1)
Entrez Gene Symbol CXCL10
UniProt ID P02778
UniProt Comment
  • Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Targeted by drugs (based on IPA annotation)
  • MDX-1100
Biomarker applications (based on IPA annotation)
  • diagnosis
  • efficacy
  • unspecified application
Wiki Pathways
  • Regulation of toll-like receptor signaling pathway
  • Toll-like receptor signaling pathway
  • Type II interferon signaling (IFNG)
Pathway Interaction Database
  • CXCR3-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
Pathway Studio
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs11548618).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • ART3 ADP-ribosyltransferase 3
  • CXCL10 chemokine (C-X-C motif) ligand 10

 

Results from other genome-wide association studies

No associations available.