HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 189

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TECK cis Discovery rs3848570 19:8,145,928 C/T 0.05 993 -0.917 0.096 7.6×10-21 -1.500 6×10-18 3×10-7

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 25 (TECK)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-C motif chemokine 25 (TECK)

Target (abbrv.) TECK
Target (full name) C-C motif chemokine 25
Somalogic ID (Sequence ID) SL003197 (2705-5_2)
Entrez Gene Symbol CCL25
UniProt ID O15444
UniProt Comment
  • Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biomarker applications (based on IPA annotation)
  • disease progression
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events

All locus annotations are based on the sentinel SNP (rs3848570) and 9 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • ELAVL1 ELAV like RNA binding protein 1
  • FBN3 fibrillin 3

 

Results from other genome-wide association studies

No associations available.