Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SIRT2 | trans | Discovery | rs1801689 | 17:64,210,580 | A/C | 0.03 | 996 | 1.132 | 0.124 | 2.8×10-19 | 1.330 | 1.4×10-9 | 0.095 |
Dkk-4 | trans | Discovery | rs1801689 | 17:64,210,580 | A/C | 0.03 | 996 | 0.722 | 0.116 | 7×10-10 | 1.190 | 8.4×10-10 | 7.1×10-9 |
Target (abbrv.) | SIRT2 |
Target (full name) | NAD-dependent protein deacetylase sirtuin-2 |
Somalogic ID (Sequence ID) | SL006629 (5030-52_1) |
Entrez Gene Symbol | SIRT2 |
UniProt ID | Q8IXJ6 |
UniProt Comment |
|
Pathway Interaction Database |
|
Target (abbrv.) | Dkk-4 |
Target (full name) | Dickkopf-related protein 4 |
Somalogic ID (Sequence ID) | SL010612 (3365-7_2) |
Entrez Gene Symbol | DKK4 |
UniProt ID | Q9UBT3 |
UniProt Comment |
|
Pathway Interaction Database |
|
Reactome |
|
All locus annotations are based on the sentinel SNP (rs1801689) and 4 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Genes hit or close-by |
Trait | P | Study | Source |
---|---|---|---|
LDL cholesterol | 9.4×10-14 | 23063622 (PMID) | GRASP2 nonQTL |
Total cholesterol | 4.9×10-6 | 23063622 (PMID) | GRASP2 nonQTL |
Triglycerides | 3.4×10-5 | 24097068 (PMID) | Supplemental file |