Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SIRT2 | trans | Discovery | rs8178847 | 17:64,216,815 | C/T | 0.07 | 996 | 0.790 | 0.087 | 8.2×10-19 | 1.210 | 1.4×10-8 | 0.034 |
SIRT2 | trans | Replication | rs11651658 | 17:64,198,640 | A/G | 0.05 | 337 | 0.400 | 0.162 | 0.014 | 1.120 | 0.113 | 0.678 |
Dkk-4 | trans | Discovery | rs8178847 | 17:64,216,815 | C/T | 0.07 | 996 | 0.690 | 0.081 | 4.1×10-17 | 1.180 | 4×10-17 | 7.5×10-16 |
Dkk-4 | trans | Replication | rs11651658 | 17:64,198,640 | A/G | 0.05 | 337 | 0.320 | 0.127 | 0.012 | 1.160 | 0.007 | 0.001 |
Target (abbrv.) | SIRT2 |
Target (full name) | NAD-dependent protein deacetylase sirtuin-2 |
Somalogic ID (Sequence ID) | SL006629 (5030-52_1) |
Entrez Gene Symbol | SIRT2 |
UniProt ID | Q8IXJ6 |
UniProt Comment |
|
Pathway Interaction Database |
|
Target (abbrv.) | Dkk-4 |
Target (full name) | Dickkopf-related protein 4 |
Somalogic ID (Sequence ID) | SL010612 (3365-7_2) |
Entrez Gene Symbol | DKK4 |
UniProt ID | Q9UBT3 |
UniProt Comment |
|
Pathway Interaction Database |
|
Reactome |
|
All locus annotations are based on the sentinel SNP (rs8178847) and 25 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Genes hit or close-by |
Trait | P | Study | Source |
---|---|---|---|
cg25751482 (chr17:64301303) | 8.8×10-5 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
Partial epilepsy | 2.2×10-4 | 20522523 (PMID) | GRASP2 nonQTL |