Locus 268

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
ADAMTS-5	cis	Discovery	rs990529	21:28,346,546	C/G	0.38	997	0.329	0.041	1.6×10^-15	1.070	8.8×10^-10	1.2×10^-4

Regional association plots

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)

Download the association data used to generate this plot

Boxplots and histograms for top associations

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)

Target (abbrv.)	ADAMTS-5
Target (full name)	A disintegrin and metalloproteinase with thrombospondin motifs 5
Somalogic ID (Sequence ID)	SL004626 (3168-8_2)
Entrez Gene Symbol	ADAMTS5
UniProt ID	Q9UNA0
UniProt Comment	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
Wiki Pathways	Endochondral Ossification
Reactome	Degradation of the extracellular matrix O-glycosylation of TSR domain-containing proteins

All locus annotations are based on the sentinel SNP (rs990529).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Results from other genome-wide association studies

No associations available.