HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 285

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICA cis Discovery rs2523710 6:31,450,909 G/A 0.21 994 -0.425 0.054 6.5×10-15 -1.360 5.8×10-16 5.3×10-6
MICA cis Replication rs2523710 6:31,450,909 G/A 0.16 337 -0.142 0.097 0.146 -1.080 0.158 0.162

 

Regional association plots

MHC class I polypeptide-related sequence A (MICA)

 

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence A (MICA)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

MHC class I polypeptide-related sequence A (MICA)

Target (abbrv.) MICA
Target (full name) MHC class I polypeptide-related sequence A
Somalogic ID (Sequence ID) SL005199 (2730-58_2)
Entrez Gene Symbol MICA
UniProt ID Q29983
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs2523710).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

eQTL genes
  • DXO decapping exoribonuclease
  • LST1 leukocyte specific transcript 1
  • HLA-B major histocompatibility complex, class I, B
  • AGER advanced glycosylation end product-specific receptor
  • MICB MHC class I polypeptide-related sequence B
  • PSMB8 proteasome (prosome, macropain) subunit, beta type, 8

 

Results from other genome-wide association studies

Trait P Study Source
Height 9.2×10-12 25282103 (PMID) Supplemental file
Rheumatoid arthritis 2.3×10-6 20453842 (PMID) GRASP2 nonQTL
Gene expression of LST1 [probe ILMN_22195] in osteoblasts with treatment interaction 2.8×10-5 21283786 (PMID) GRASP2 eQTL
Hip circumfence, adjusted for BMI 1.3×10-4 25673412 (PMID) Supplemental file
Total cholesterol 1.6×10-4 24097068 (PMID) Supplemental file