HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 300

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-1Rrp2 cis Discovery rs1922291 2:102,828,817 G/A 0.40 996 0.341 0.044 1.3×10-14 1.040 5.3×10-8 2.4×10-4
IL-1Rrp2 cis Replication rs2302621 2:102,842,124 A/C 0.47 337 0.142 0.066 0.031 1.020 0.095 0.288

 

Regional association plots

Interleukin-1 receptor-like 2 (IL-1Rrp2)

 

Boxplots and histograms for top associations

Interleukin-1 receptor-like 2 (IL-1Rrp2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 2 (IL-1Rrp2)

Target (abbrv.) IL-1Rrp2
Target (full name) Interleukin-1 receptor-like 2
Somalogic ID (Sequence ID) SL004875 (2994-71_2)
Entrez Gene Symbol IL1RL2
UniProt ID Q9HB29
UniProt Comment
  • Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

All locus annotations are based on the sentinel SNP (rs1922291) and 6 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL1RL2 interleukin 1 receptor-like 2
eQTL genes
  • IL1RL2 interleukin 1 receptor-like 2

 

Results from other genome-wide association studies

Trait P Study Source
cg08023416 (chr2:102803811) 3.3×10-310 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg14837955 (chr2:102803411) 7.5×10-101 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg22797169 (chr2:102803383) 5.1×10-95 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg15077070 (chr2:102803314) 5.2×10-24 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Asthma 6.2×10-5 20860503 (PMID) GRASP2 nonQTL
Serum ratio of (2-oleoylglycerophosphocholine*)/(allantoin) 9.8×10-5 21886157 (PMID) GRASP2 metabQTL