HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 303

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
NPS-PLA2 cis Discovery rs17354650 1:20,390,322 C/T 0.28 996 0.356 0.046 1.7×10-14 1.100 7.5×10-14 1.1×10-11
NPS-PLA2 cis Replication rs72661034 1:20,311,680 A/C 0.15 337 0.377 0.078 2×10-6 1.190 3×10-5 0.012

 

Regional association plots

Phospholipase A2, membrane associated (NPS-PLA2)

 

Boxplots and histograms for top associations

Phospholipase A2, membrane associated (NPS-PLA2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Phospholipase A2, membrane associated (NPS-PLA2)

Target (abbrv.) NPS-PLA2
Target (full name) Phospholipase A2, membrane associated
Somalogic ID (Sequence ID) SL002528 (2692-74_2)
Entrez Gene Symbol PLA2G2A
UniProt ID P14555
UniProt Comment
  • Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Targeted by drugs (based on IPA annotation)
  • varespladib methyl
  • varespladib
  • indomethacin
Biomarker applications (based on IPA annotation)
  • efficacy
  • prognosis
  • safety
Wiki Pathways
  • Eicosanoid Synthesis
  • MicroRNAs in cardiomyocyte hypertrophy
Pathway Interaction Database
  • Glypican 1 network
Reactome
  • Acyl chain remodelling of PC
  • Acyl chain remodelling of PE
  • Acyl chain remodelling of PG
  • Acyl chain remodelling of PI
  • Acyl chain remodelling of PS
  • Synthesis of PA

All locus annotations are based on the sentinel SNP (rs17354650).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • PLA2G5 phospholipase A2, group V
eQTL genes
  • MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
  • OTUD3 OTU deubiquitinase 3

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (cysteine-glutathione disulfide)/(glycerate) 7.5×10-5 21886157 (PMID) GRASP2 metabQTL
Gene expression of PLA2G5 [probe 2323847] in brain cortex 1.9×10-4 19222302 (PMID) GRASP2 eQTL