HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 328

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MP2K2 trans Discovery rs9577481 13:113,860,900 G/A 0.17 996 0.421 0.056 1.2×10-13 1.130 1.2×10-13 1.2×10-12
MP2K2 trans Replication rs9549688 13:113,846,989 G/C 0.13 337 0.137 0.105 0.193 1.040 0.29 0.143

 

Regional association plots

Dual specificity mitogen-activated protein kinase kinase 2 (MP2K2)

 

Boxplots and histograms for top associations

Dual specificity mitogen-activated protein kinase kinase 2 (MP2K2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Dual specificity mitogen-activated protein kinase kinase 2 (MP2K2)

Target (abbrv.) MP2K2
Target (full name) Dual specificity mitogen-activated protein kinase kinase 2
Somalogic ID (Sequence ID) SL010501 (3628-3_4)
Entrez Gene Symbol MAP2K2
UniProt ID P36507
UniProt Comment
  • Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Targeted by drugs (based on IPA annotation)
  • selumetinib
  • trametinib
  • dabrafenib/trametinib
Wiki Pathways
  • B Cell Receptor Signaling Pathway
  • EGF/EGFR Signaling Pathway
  • EPO Receptor Signaling
  • Focal Adhesion
  • Hypothetical Network for Drug Addiction
  • IL-1 signaling pathway
  • IL-2 Signaling pathway
  • IL-5 signaling pathway
  • IL-6 signaling pathway
  • IL-7 signaling pathway
  • IL-9 signaling pathway
  • Insulin Signaling
  • Integrin-mediated cell adhesion
  • Kit receptor signaling pathway
  • Leptin signaling pathway
  • MAPK Cascade
  • MAPK signaling pathway
  • MicroRNAs in cardiomyocyte hypertrophy
  • Prolactin Signaling Pathway
  • Regulation of Actin Cytoskeleton
  • Regulation of toll-like receptor signaling pathway
  • Serotonin HTR1 Group and FOS Pathway
  • Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
  • Serotonin Receptor 4/6/7 and NR3C Signaling
  • Signaling of Hepatocyte Growth Factor Receptor
  • TCR Signaling Pathway
  • TGF beta Signaling Pathway
  • Toll-like receptor signaling pathway
Pathway Interaction Database
  • CXCR3-mediated signaling events
  • Cellular roles of Anthrax toxin
  • Ceramide signaling pathway
  • Downstream signaling in naïve CD8+ T cells
  • Endothelins
  • ErbB1 downstream signaling
  • ErbB2/ErbB3 signaling events
  • Fc-epsilon receptor I signaling in mast cells
  • GMCSF-mediated signaling events
  • IL2-mediated signaling events
  • Netrin-mediated signaling events
  • Nongenotropic Androgen signaling
  • PDGFR-beta signaling pathway
  • SHP2 signaling
  • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
  • Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signaling events mediated by VEGFR1 and VEGFR2
  • mTOR signaling pathway
Reactome
  • ERK2 activation
  • MEK activation
  • RAF phosphorylates MEK
  • Signal transduction by L1
  • Signaling by FGFR1
  • Signaling by FGFR2
  • Signaling by FGFR3
  • Signaling by FGFR4
  • Uptake and function of anthrax toxins
Pathway Studio
  • ADRA1 → prostaglandin generation
  • ADRA1 → vasoconstriction
  • ADRA1A → IL6 production
  • ADRA2C/ADRB2 → synaptic endocytosis
  • ADRA2C/ADRB2 → vasoconstriction
  • ADRB1 → prostaglandin generation
  • AGER → CREB/SP1 signaling
  • AdenosineR → AP-1 signaling
  • AdrenergicRa → ELK-SRF signaling
  • AdrenergicRa → STAT3 signaling
  • AdrenergicRb → CREB signaling
  • AdrenergicRb → STAT3 signaling
  • AngiopoietinR → AP-1 signaling
  • AngiotensinR → CREB/ELK-SRF/TP53 signaling
  • B-cell receptor → AP-1 signaling
  • BDKRB1/2 → prostaglandin generation
  • CD19 → AP-1/ELK-SRF signaling
  • CD38 → NF-kB signaling
  • CD8+ T-cell Activation
  • CHRM1 → IL2 production
  • CHRM1/2/3 → vascular motility
  • CHRNA7 → NOS1 production
  • CNR1/2 → IL1B/2/4/6/10 production
  • CannabinoidR → AP-1/EGR signaling
  • CholecystokininR → ELK-SRF signaling
  • CholinergicRm → CREB/ELK-SRF signaling
  • CholinergicRn → CREB signaling
  • DopamineR1 → CREB/ELK-SRF signaling
  • DopamineR2 → AP-1/CREB/ELK-SRF signaling
  • EDG2 → ELK-SRF signaling
  • EDG3/5 → AP-1/ELK-SRF signaling
  • EDNRA/B → vascular motility
  • EGFR → AP-1/ATF2 signaling
  • EGFR → AP-1/CREB/ELK-SRF/MYC signaling
  • EGFR → SMAD1 signaling
  • EGFR/ERBB2 → HIF1A signaling
  • EGFR/ERBB2 → TP53 signaling
  • ERBB2/3 → EP300/ETS/ETV/SP1 signaling
  • EctodysplasinR → AP-1 signaling
  • EndothelinRa → AP-1/CREB signaling
  • EndothelinRb → AP-1/CREB/ELK-SRF signaling
  • ErythropoietinR → AP-1/CREB/MYC signaling
  • ErythropoietinR → ELK-SRF/FOS signaling
  • FGFR → AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
  • FGFR → RUNX2 signaling
  • FSHR → CREB/ELK-SRF/GATA4 signaling
  • FcIgER → ELK-SRF signaling
  • FibronectinR → AP-1/ELK-SRF/SREBF signaling
  • GABA(B)R → postsynaptic inhibition
  • GALR1/2/3 → POMC/NPY production
  • GDNF → HSF1 signaling
  • GHR → ELK-SRF/MYC signaling
  • GNRHR → ELK-SRF signaling
  • GRM1/5 → CREB signaling
  • GlucagonR → CREB/ELK-SRF/SP1 signaling
  • HGFR → AP-1/CREB/MYC signaling
  • HRH2/4 → IL6/10 production
  • HTR1 → IL6 production
  • HTR4/6/7 → cation channels
  • HTR5 → TNF production
  • HTR7 → IL6 production
  • ICAM1 → AP-1/CREB/ELK-SRF signaling
  • IGF1R → ELK-SRF/HIF1A/MYC/SREBF signaling
  • IL1R → NF-kB signaling
  • IL2R → ELK-SRF/MYC signaling
  • IL4R → ELK-SRF/HMGY signaling
  • IL6R → CEBP/ELK-SRF signaling
  • IL8R → CREB/EGR signaling
  • InsulinR → ELK-SRF/SREBF signaling
  • KIT → MITF signaling
  • LeptinR → ELK-SRF signaling
  • Model of T-cell Maturation
  • NCAM1 → CREB/ELK-SRF/MYC signaling
  • NGFR → AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
  • NMDA receptors → Ca2+/CREB activation/PGE2 synthesis
  • NPY1R → CRH/POMC production
  • NTRK → AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors
  • Natural Killer Cell Activation through ITAM-Containing Receptors
  • Natural Killer Cell Activation through ITSM-Containing Receptors
  • NeuropeptideYR → ATF/CREB signaling
  • NeurotensinR → ELK-SRF/AP-1/EGR signaling
  • Nociception-related DRD1/5 expression targets
  • Nociception-related DRD2 expression targets
  • Nociception-related IL1B expression targets
  • Nociception-related IL6 expression targets
  • Nociception-related NTSR1 expression targets
  • Notch → TCF3 signaling
  • OPRK → pain perception
  • OpioidR → CREB/ELK-SRF/STAT3 signaling
  • OxytocinR → ELK-SRF/GATA/AP-1 signaling
  • P2RY11/13/14 → IL8/10 production
  • PDGFR → AP-1/MYC signaling
  • PECAM → SP1 signaling
  • PTAFR → AP-1/ATF1/CREB/ERK-SRF signaling
  • PTGER1/4 → vascular motility
  • PTGER2/3 → inflammation-related expression targets
  • PTGIR → IL6 production
  • PTPRC → BCL6 signaling
  • ProstaglandinFR → ATF1/ELK-SRF/CREB signaling
  • ProstaglandinIR → ATF1/ELK-SRF/CREB signaling
  • Regulation of potassium flux
  • Regulatory T-cell Differentiation
  • SELE → ELK-SRF signaling
  • SerotoninR1 → FOS signaling
  • SerotoninR2 → ELK-SRF/GATA4 signaling
  • SerotoninR4/6/7 → NR3C signaling
  • Summarized nociception-related expression targets
  • Summarized vascular motility pathway
  • T-cell Receptor Signaling
  • T-cell receptor → AP-1 signaling
  • T-cell-Dependent B-cell Activation
  • T-cell-Independent B-cell Activation
  • TNFR → AP-1/ATF/TP53 signaling
  • TNFR → CREB/ELK-SRF signaling
  • TNFRSF1A → AP-1/ATF/TP53 signaling
  • TNFRSF1A → CREB/ELK-SRF signaling
  • TNFRSF6 → HSF1 signaling
  • TachykininR → ELK-SRF signaling
  • Th1 Cell Differentiation
  • Th2 Cell Differentiation
  • ThrombinR → AP-1/CREB/ELK-SRF/SP1 signaling
  • ThrombopoietinR → AP-1/CREB/ELK-SRF/MYC signaling
  • ThrombopoietinR → SP1 signaling
  • ThromboxaneR → CREB signaling
  • UrokinaseR → ELK-SRF signaling
  • VEGFR → AP-1/CREB/MYC signaling
  • VEGFR → ATF/CREB/ELK-SRF signaling
  • VIPR → CREB/CEBP signaling
  • VasopressinR1 → CREB/ELK-SRF/AP-1/EGR signaling
  • VasopressinR2 → CREB/ELK-SRF/AP-1/EGR signaling

All locus annotations are based on the sentinel SNP (rs9577481).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
eQTL genes
  • PCID2 PCI domain containing 2

 

Results from other genome-wide association studies

No associations available.