HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 369

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
LD78-beta cis Discovery rs16971895 17:34,386,399 G/A 0.04 995 0.776 0.108 1.2×10-12 1.100 5.9×10-8 0.003
LD78-beta cis Replication rs16971895 17:34,386,399 G/A 0.08 337 0.365 0.110 0.001 1.090 4.2×10-4 0.001

 

Regional association plots

C-C motif chemokine 3-like 1 (LD78-beta)

 

Boxplots and histograms for top associations

C-C motif chemokine 3-like 1 (LD78-beta)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 3-like 1 (LD78-beta)

Target (abbrv.) LD78-beta
Target (full name) C-C motif chemokine 3-like 1
Somalogic ID (Sequence ID) SL004355 (2783-18_2)
Entrez Gene Symbol CCL3L1
UniProt ID P16619
UniProt Comment
  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
Reactome
  • Chemokine receptors bind chemokines

All locus annotations are based on the sentinel SNP (rs16971895) and 4 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

 

Results from other genome-wide association studies

No associations available.