HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 397

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-17E trans Discovery rs7121784 11:120,159,052 C/A 0.15 995 0.425 0.061 5.3×10-12 1.110 2.3×10-6 0.246
IL-17E trans Replication rs7121784 11:120,159,052 C/A 0.15 337 -0.016 0.092 0.86 -1.040 0.362 0.453

 

Regional association plots

 

Boxplots and histograms for top associations

Interleukin-25 (IL-17E)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-25 (IL-17E)

Target (abbrv.) IL-17E
Target (full name) Interleukin-25
Somalogic ID (Sequence ID) SL004351 (4137-57_2)
Entrez Gene Symbol IL25
UniProt ID Q9H293
UniProt Comment
  • Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

All locus annotations are based on the sentinel SNP (rs7121784).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • POU2F3 POU class 2 homeobox 3

 

Results from other genome-wide association studies

No associations available.