HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 40

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
KYNU cis Discovery rs9013 2:143,798,189 A/G 0.16 997 -1.045 0.050 1×10-81 -1.350 9.8×10-64 1.1×10-10
KYNU cis Replication rs3768844 2:143,796,694 A/G 0.17 337 -0.686 0.073 8×10-19 -1.260 3.9×10-17 5.4×10-12

 

Regional association plots

 

Boxplots and histograms for top associations

Kynureninase (KYNU)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Kynureninase (KYNU)

Target (abbrv.) KYNU
Target (full name) Kynureninase
Somalogic ID (Sequence ID) SL013969 (4559-64_2)
Entrez Gene Symbol KYNU
UniProt ID Q16719
UniProt Comment
  • Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

All locus annotations are based on the sentinel SNP (rs9013) and 27 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of KYNU in blood 6.9×10-16 21829388 (PMID) GRASP2 eQTL
Gene expression of KYNU in peripheral blood monocytes 1.3×10-9 20502693 (PMID) GRASP2 eQTL
Gene expression of ARHGAP15 in peripheral blood monocytes 2.9×10-7 20502693 (PMID) GRASP2 eQTL
Gene expression of ARID3A in peripheral blood monocytes 3.3×10-6 20502693 (PMID) GRASP2 eQTL
Crohn's disease, combined control dataset, gender differentiated 1.4×10-5 17554300 (PMID) GRASP2 nonQTL
Serum ratio of (leucylleucine)/(phenylacetate) 2.9×10-4 21886157 (PMID) GRASP2 metabQTL
Serum ratio of (caffeine)/(theophylline) 3.5×10-4 21886157 (PMID) GRASP2 metabQTL