HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 401

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
PIGR cis Discovery rs35400166 1:207,064,011 G/- 0.48 995 -0.304 0.044 6.3×10-12 -1.120 3.6×10-11 2.8×10-8
PIGR cis Replication rs291096 1:207,110,936 G/A 0.47 337 0.289 0.073 8.9×10-5 1.140 1.4×10-4 0.004

 

Regional association plots

Polymeric immunoglobulin receptor (PIGR)

 

Boxplots and histograms for top associations

Polymeric immunoglobulin receptor (PIGR)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Polymeric immunoglobulin receptor (PIGR)

Target (abbrv.) PIGR
Target (full name) Polymeric immunoglobulin receptor
Somalogic ID (Sequence ID) SL005797 (3216-2_2)
Entrez Gene Symbol PIGR
UniProt ID P01833
UniProt Comment
  • This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Biomarker applications (based on IPA annotation)
  • unspecified application
Wiki Pathways
  • Integrated Breast Cancer Pathway
Pathway Interaction Database
  • IL4-mediated signaling events

All locus annotations are based on the sentinel SNP (rs35400166).
However, the sentinel SNP is not contained in SNiPA's database (1000 Genomes Project, phase 3 version 5, European population). Thus, no information about linked genes or further functional annotation is available.

 

Results from other genome-wide association studies

No associations available.