HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 402

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
SPARCL1 cis Discovery rs1462372 4:88,478,750 T/C 0.33 997 0.321 0.046 6.3×10-12 1.060 1.4×10-11 1.5×10-11
SPARCL1 cis Replication rs6847175 4:88,481,387 A/G 0.45 337 0.340 0.066 4×10-7 1.090 2.4×10-7 1.5×10-6

 

Regional association plots

 

Boxplots and histograms for top associations

SPARC-like protein 1 (SPARCL1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

SPARC-like protein 1 (SPARCL1)

Target (abbrv.) SPARCL1
Target (full name) SPARC-like protein 1
Somalogic ID (Sequence ID) SL005488 (4467-49_2)
Entrez Gene Symbol SPARCL1
UniProt ID Q14515
UniProt Comment
  • Secreted
Biomarker applications (based on IPA annotation)
  • disease progression

All locus annotations are based on the sentinel SNP (rs1462372) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

eQTL genes
  • SPARCL1 SPARC-like 1 (hevin)
  • HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13

 

Results from other genome-wide association studies

Trait P Study Source
stearidonate (18:4n3) 1.9×10-5 24816252 (PMID) gwas.eu via SNiPA