HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 409

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-1 R4 cis Discovery rs3917254 2:102,776,518 G/A 0.10 994 -0.440 0.064 1.2×10-11 -1.200 3.8×10-12 1.6×10-6
IL-1 R4 cis Replication rs3917254 2:102,776,518 G/A 0.19 337 -0.174 0.086 0.043 -1.080 0.039 0.146

 

Regional association plots

Interleukin-1 receptor-like 1 (IL-1 R4)

 

Boxplots and histograms for top associations

Interleukin-1 receptor-like 1 (IL-1 R4)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 1 (IL-1 R4)

Target (abbrv.) IL-1 R4
Target (full name) Interleukin-1 receptor-like 1
Somalogic ID (Sequence ID) SL004146 (4234-8_2)
Entrez Gene Symbol IL1RL1
UniProt ID Q01638
UniProt Comment
  • Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

All locus annotations are based on the sentinel SNP (rs3917254).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL1R1 interleukin 1 receptor, type I

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (laurate (12:0))/(N-acetylalanine) 2.8×10-6 21886157 (PMID) GRASP2 metabQTL
Asthma 3.8×10-4 20159242 (PMID) GRASP2 nonQTL