HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 418

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-16 cis Discovery rs11072996 15:81,529,410 T/C 0.07 997 -0.537 0.079 2.1×10-11 -1.130 5.2×10-13 4.9×10-9

 

Regional association plots

 

Boxplots and histograms for top associations

Interleukin-16 (IL-16)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Interleukin-16 (IL-16)

Target (abbrv.) IL-16
Target (full name) Interleukin-16
Somalogic ID (Sequence ID) SL000474 (2774-10_3)
Entrez Gene Symbol IL16
UniProt ID Q14005
UniProt Comment
  • Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Pathway Studio
  • HRH2/4 → IL6/10 production
  • Summarized nociception-related expression targets
  • T-cell receptor → AP-1 signaling
  • T-cell receptor → ATF/CREB signaling
  • T-cell receptor → CREBBP signaling
  • T-cell receptor → NF-kB signaling
  • T-cell receptor → NFATC signaling
  • T-cell receptor → STAT signaling

All locus annotations are based on the sentinel SNP (rs11072996).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL16 interleukin 16

 

Results from other genome-wide association studies

No associations available.

Imputed data reveals in IL16R that is a risk variant for cancer.

This locus harbours a cis-pQTL to Interleukin-16 (IL16). Replication was not attempted. Imputed data reveals a much stronger association, including coding variant rs11556218 (p=6.36×10-27), which is a risk variant for cancer in a meta-analysis [PubMed]

The information gathered here is a result of an attempt to keep track of all interesting information that we encountered while investigating these loci. Please bear in mind that the annotation given here is neither complete nor free of errors, and that all information provided here should be confirmed by additional literature research before being used as a basis for firm conclusions or further experiments.