HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 420

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Angiotensinogen cis Discovery rs2493151 1:230,878,561 G/A 0.23 994 0.335 0.049 2.2×10-11 1.080 6.3×10-11 7×10-10
Angiotensinogen cis Replication rs1317181 1:230,873,488 C/A 0.48 337 0.146 0.067 0.03 1.030 0.092 0.186

 

Regional association plots

 

Boxplots and histograms for top associations

Angiotensinogen

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Angiotensinogen

Target (abbrv.) Angiotensinogen
Target (full name) Angiotensinogen
Somalogic ID (Sequence ID) SL000271 (3484-60_2)
Entrez Gene Symbol AGT
UniProt ID P01019
UniProt Comment
  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Biomarker applications (based on IPA annotation)
  • efficacy
Wiki Pathways
  • ACE Inhibitor Pathway
  • Adipogenesis
  • IL-6 signaling pathway
  • MicroRNAs in cardiomyocyte hypertrophy
  • Monoamine Transport
  • Physiological and Pathological Hypertrophy of the Heart
Pathway Interaction Database
  • AP-1 transcription factor network
  • Signaling events mediated by PRL
Reactome
  • G alpha (i) signalling events
  • G alpha (q) signalling events
  • Metabolism of Angiotensinogen to Angiotensins
  • PPARA activates gene expression
  • Peptide ligand-binding receptors
Pathway Studio
  • AngiotensinR → CREB/ELK-SRF/TP53 signaling
  • AngiotensinR → STAT signaling

All locus annotations are based on the sentinel SNP (rs2493151) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (1-arachidonoylglycerophosphocholine*)/(4-acetamidobutanoate) 3.7×10-5 21886157 (PMID) GRASP2 metabQTL