HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 422

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
NXPH1 trans Discovery rs668555 1:57,426,454 T/C 0.29 994 0.323 0.048 2.4×10-11 1.090 4×10-11 1.8×10-9
NXPH1 trans Replication rs658285 1:57,416,335 G/A 0.35 337 0.262 0.074 4.9×10-4 1.100 3×10-4 0.002

 

Regional association plots

 

Boxplots and histograms for top associations

Neurexophilin-1 (NXPH1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Neurexophilin-1 (NXPH1)

Target (abbrv.) NXPH1
Target (full name) Neurexophilin-1
Somalogic ID (Sequence ID) SL012457 (4562-1_2)
Entrez Gene Symbol NXPH1
UniProt ID P58417
UniProt Comment
  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

All locus annotations are based on the sentinel SNP (rs668555) and 5 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF))/(scyllo-inositol) 1.1×10-5 21886157 (PMID) GRASP2 metabQTL
Recurrent early onset major depressive disorder (males) 1.7×10-4 20125088 (PMID) GRASP2 nonQTL