HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 428

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Siglec-6 cis Discovery rs35931837 19:52,033,158 C/T 0.11 995 -0.481 0.072 3.6×10-11 -1.050 0.118 0.038

 

Regional association plots

Sialic acid-binding Ig-like lectin 6 (Siglec-6)

 

Boxplots and histograms for top associations

Sialic acid-binding Ig-like lectin 6 (Siglec-6)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Sialic acid-binding Ig-like lectin 6 (Siglec-6)

Target (abbrv.) Siglec-6
Target (full name) Sialic acid-binding Ig-like lectin 6
Somalogic ID (Sequence ID) SL005217 (2741-22_2)
Entrez Gene Symbol SIGLEC6
UniProt ID O43699
UniProt Comment
  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

All locus annotations are based on the sentinel SNP (rs35931837).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • SIGLEC6 sialic acid binding Ig-like lectin 6
eQTL genes
  • SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)

 

Results from other genome-wide association studies

No associations available.