HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 433

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TARC trans Discovery rs2228467 3:42,906,116 T/C 0.07 995 0.551 0.083 4.2×10-11 1.170 4.8×10-12 7.1×10-10

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 17 (TARC)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-C motif chemokine 17 (TARC)

Target (abbrv.) TARC
Target (full name) C-C motif chemokine 17
Somalogic ID (Sequence ID) SL003196 (3519-3_2)
Entrez Gene Symbol CCL17
UniProt ID Q92583
UniProt Comment
  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Pathway Interaction Database
  • IL4-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines

All locus annotations are based on the sentinel SNP (rs2228467).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
cg11020853 (chr3:43020540) 2.1×10-33 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Cerebrospinal fluid levels of Alzheimer's disease-related proteins 4×10-18 25340798 (PMID) GWAS Catalog via SNiPA
Monocyte count 2.4×10-8 23314186 (PMID) GRASP2 nonQTL
Fasting serum eotaxin (pg/mL) in children 1.9×10-6 23251661 (PMID) GRASP2 nonQTL