HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Locus annotations

Locus 59

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
RAP trans Discovery rs1622406 6:31,308,862 C/T 0.03 997 2.011 0.112 7.1×10-63 2.800 4.3×10-217 3.2×10-229

 

Regional association plots

alpha-2-macroglobulin receptor-associated protein (RAP)

 

Boxplots and histograms for top associations

alpha-2-macroglobulin receptor-associated protein (RAP)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

alpha-2-macroglobulin receptor-associated protein (RAP)

Target (abbrv.) RAP
Target (full name) alpha-2-macroglobulin receptor-associated protein
Somalogic ID (Sequence ID) SL005263 (3640-14_3)
Entrez Gene Symbol LRPAP1
UniProt ID P30533
UniProt Comment
  • Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Pathway Interaction Database
  • Lissencephaly gene (LIS1) in neuronal migration and development
  • Reelin signaling pathway
  • Signaling events mediated by the Hedgehog family

All locus annotations are based on the sentinel SNP (rs1622406) and 17 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.

Linked genes

Genes hit or close-by
Potentially regulated genes

 

Results from other genome-wide association studies

Trait P Study Source
Height 1.2×10-8 25282103 (PMID) Supplemental file
Crohn's disease 1×10-5 Supplemental file
Hip circumfence, adjusted for BMI 1.7×10-5 25673412 (PMID) Supplemental file
Rheumatoid arthritis 2.2×10-5 20453842 (PMID) GRASP2 nonQTL