Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WFKN2 | cis | Discovery | rs3803884 | 17:48,919,039 | T/C | 0.31 | 997 | 0.563 | 0.040 | 1.4×10-40 | 1.150 | 3×10-39 | 7.2×10-40 |
WFKN2 | cis | Replication | rs4533326 | 17:48,909,608 | A/C | 0.43 | 337 | 0.435 | 0.054 | 1.2×10-14 | 1.160 | 6.8×10-15 | 7.2×10-14 |
Target (abbrv.) | WFKN2 |
Target (full name) | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 |
Somalogic ID (Sequence ID) | SL010391 (3235-50_2) |
Entrez Gene Symbol | WFIKKN2 |
UniProt ID | Q8TEU8 |
UniProt Comment |
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All locus annotations are based on the sentinel SNP (rs3803884) and 38 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Genes hit or close-by |
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Potentially regulated genes |
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eQTL genes |
|
Trait | P | Study | Source |
---|---|---|---|
cg14350358 (chr17:48913293) | 9.6×10-50 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
cg22842797 (chr17:48912597) | 2.3×10-49 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
cg13655803 (chr17:48912788) | 4.3×10-45 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
cg07168556 (chr17:48912459) | 1.1×10-22 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
Gene expression of TOB1 [probe 228834_at] in lymphoblastoid cell lines | 9×10-19 | 17873877 (PMID) | GRASP2 eQTL |
cg22469388 (chr17:48912836) | 4.2×10-18 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
cg06827038 (chr17:48912976) | 6.3×10-15 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
Differential splicing of NDFIP1 [probeset 2833082] in lymphoblastoid cell lines | 3×10-9 | 19052777 (PMID) | GRASP2 eQTL |
Gene expression of TOB1 in blood | 2.5×10-6 | 21829388 (PMID) | GRASP2 eQTL |
Gene expression of TOB1 [probe ILMN_13735] in untreated osteoblasts | 4.3×10-6 | 21283786 (PMID) | GRASP2 eQTL |
Gene expression of FIS in peripheral blood monocytes | 4.4×10-6 | 20502693 (PMID) | GRASP2 eQTL |
cg20493283 (chr17:48912140) | 5.1×10-6 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
Gene expression of VIM in peripheral blood monocytes | 9.5×10-6 | 20502693 (PMID) | GRASP2 eQTL |
Gene expression of TOB1 (ENSG00000141232) in dendritic cells | 4.9×10-5 | 22233810 (PMID) | GRASP2 eQTL |
Major depressive disorder (broad definition) (females) | 1.3×10-4 | 20038947 (PMID) | GRASP2 nonQTL |
Major depressive disorder (narrow definition) (females) | 4.3×10-4 | 20038947 (PMID) | GRASP2 nonQTL |