HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 149

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICA cis Discovery rs17206736 6:31,389,768 T/G 0.08 997 -0.876 0.080 1.3×10-26 -1.890 3×10-29 9.5×10-13


Regional association plots

MHC class I polypeptide-related sequence A (MICA)


Boxplots and histograms for top associations

MHC class I polypeptide-related sequence A (MICA)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

MHC class I polypeptide-related sequence A (MICA)

Target (abbrv.) MICA
Target (full name) MHC class I polypeptide-related sequence A
Somalogic ID (Sequence ID) SL005199 (2730-58_2)
Entrez Gene Symbol MICA
UniProt ID Q29983
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs17206736) and 18 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • MICA MHC class I polypeptide-related sequence A
  • HCP5 HLA complex P5 (non-protein coding)
Potentially regulated genes
eQTL genes
  • MICA MHC class I polypeptide-related sequence A
  • PSORS1C2 psoriasis susceptibility 1 candidate 2
  • CCHCR1 coiled-coil alpha-helical rod protein 1
  • HLA-B major histocompatibility complex, class I, B
  • PSORS1C1 psoriasis susceptibility 1 candidate 1
  • Y_RNA


Results from other genome-wide association studies

Trait P Study Source
Inflammatory bowel disease 1.4×10-4 Supplemental file
Ulcerative collitis 1.9×10-4 Supplemental file