HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 189

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TECK cis Discovery rs3848570 19:8,145,928 C/T 0.05 993 -0.917 0.096 7.6×10-21 -1.500 6×10-18 3×10-7


Regional association plots


Boxplots and histograms for top associations

C-C motif chemokine 25 (TECK)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-C motif chemokine 25 (TECK)

Target (abbrv.) TECK
Target (full name) C-C motif chemokine 25
Somalogic ID (Sequence ID) SL003197 (2705-5_2)
Entrez Gene Symbol CCL25
UniProt ID O15444
UniProt Comment
  • Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biomarker applications (based on IPA annotation)
  • disease progression
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events

All locus annotations are based on the sentinel SNP (rs3848570) and 9 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • ELAVL1 ELAV like RNA binding protein 1
  • FBN3 fibrillin 3


Results from other genome-wide association studies

No associations available.