HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 202

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Ck-b-8-1 cis Discovery rs1003645 17:34,340,284 T/C 0.22 995 -0.472 0.051 1.6×10-19 -1.150 2.3×10-20 3.7×10-16
Ck-b-8-1 cis Replication rs1003645 17:34,340,284 A/G 0.32 337 -0.325 0.062 3.1×10-7 -1.130 3.4×10-7 3.4×10-6


Regional association plots


Boxplots and histograms for top associations

Ck-beta-8-1 (Ck-b-8-1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Ck-beta-8-1 (Ck-b-8-1)

Target (abbrv.) Ck-b-8-1
Target (full name) Ck-beta-8-1
Somalogic ID (Sequence ID) SL003301 (3028-36_2)
Entrez Gene Symbol CCL23
UniProt ID P55773
UniProt Comment
  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
  • Formyl peptide receptors bind formyl peptides and many other ligands
  • G alpha (i) signalling events
  • G alpha (q) signalling events
Pathway Studio
  • CCR1 → STAT signaling
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs1003645) and 26 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
eQTL genes
  • CCL14 chemokine (C-C motif) ligand 14
  • CCL15-CCL14 CCL15-CCL14 readthrough (NMD candidate)
  • CCL23 chemokine (C-C motif) ligand 23


Results from other genome-wide association studies

Trait P Study Source
cg07480367 (chr17:34314535) 3.2×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of GBE1 in peripheral blood monocytes 8×10-7 20502693 (PMID) GRASP2 eQTL
Gene expression of NUP133 in peripheral blood monocytes 3.2×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of YTHDC2 in peripheral blood monocytes 5.5×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of SUV420H1 in peripheral blood monocytes 6.2×10-6 20502693 (PMID) GRASP2 eQTL