HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 228

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-1 R4 cis Discovery rs12997015 2:103,042,401 A/G 0.03 997 -1.001 0.114 7.7×10-18 -1.520 7.3×10-19 1.3×10-9
IL-1 R4 cis Replication rs11465701 2:103,057,717 A/G 0.05 337 -0.535 0.160 0.001 -1.280 0.001 0.007


Regional association plots

Interleukin-1 receptor-like 1 (IL-1 R4)


Boxplots and histograms for top associations

Interleukin-1 receptor-like 1 (IL-1 R4)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 1 (IL-1 R4)

Target (abbrv.) IL-1 R4
Target (full name) Interleukin-1 receptor-like 1
Somalogic ID (Sequence ID) SL004146 (4234-8_2)
Entrez Gene Symbol IL1RL1
UniProt ID Q01638
UniProt Comment
  • Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

All locus annotations are based on the sentinel SNP (rs12997015).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL18RAP interleukin 18 receptor accessory protein
Potentially regulated genes


Results from other genome-wide association studies

No associations available.