HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 279

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TARC cis Discovery rs9302690 16:57,442,968 G/A 0.08 997 0.621 0.078 4.2×10-15 1.180 2.3×10-14 4.2×10-11
TARC cis Replication rs28695417 16:57,443,918 G/A 0.14 337 0.298 0.089 0.001 1.210 0.001 0.035


Regional association plots


Boxplots and histograms for top associations

C-C motif chemokine 17 (TARC)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 17 (TARC)

Target (abbrv.) TARC
Target (full name) C-C motif chemokine 17
Somalogic ID (Sequence ID) SL003196 (3519-3_2)
Entrez Gene Symbol CCL17
UniProt ID Q92583
UniProt Comment
  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Pathway Interaction Database
  • IL4-mediated signaling events
  • Chemokine receptors bind chemokines

All locus annotations are based on the sentinel SNP (rs9302690) and 3 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CCL17 chemokine (C-C motif) ligand 17


Results from other genome-wide association studies

No associations available.