HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 300

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-1Rrp2 cis Discovery rs1922291 2:102,828,817 G/A 0.40 996 0.341 0.044 1.3×10-14 1.040 5.3×10-8 2.4×10-4
IL-1Rrp2 cis Replication rs2302621 2:102,842,124 A/C 0.47 337 0.142 0.066 0.031 1.020 0.095 0.288


Regional association plots

Interleukin-1 receptor-like 2 (IL-1Rrp2)


Boxplots and histograms for top associations

Interleukin-1 receptor-like 2 (IL-1Rrp2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 2 (IL-1Rrp2)

Target (abbrv.) IL-1Rrp2
Target (full name) Interleukin-1 receptor-like 2
Somalogic ID (Sequence ID) SL004875 (2994-71_2)
Entrez Gene Symbol IL1RL2
UniProt ID Q9HB29
UniProt Comment
  • Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

All locus annotations are based on the sentinel SNP (rs1922291) and 6 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL1RL2 interleukin 1 receptor-like 2
eQTL genes
  • IL1RL2 interleukin 1 receptor-like 2


Results from other genome-wide association studies

Trait P Study Source
cg08023416 (chr2:102803811) 3.3×10-310 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg14837955 (chr2:102803411) 7.5×10-101 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg22797169 (chr2:102803383) 5.1×10-95 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg15077070 (chr2:102803314) 5.2×10-24 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Asthma 6.2×10-5 20860503 (PMID) GRASP2 nonQTL
Serum ratio of (2-oleoylglycerophosphocholine*)/(allantoin) 9.8×10-5 21886157 (PMID) GRASP2 metabQTL