HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 303

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
NPS-PLA2 cis Discovery rs17354650 1:20,390,322 C/T 0.28 996 0.356 0.046 1.7×10-14 1.100 7.5×10-14 1.1×10-11
NPS-PLA2 cis Replication rs72661034 1:20,311,680 A/C 0.15 337 0.377 0.078 2×10-6 1.190 3×10-5 0.012


Regional association plots

Phospholipase A2, membrane associated (NPS-PLA2)


Boxplots and histograms for top associations

Phospholipase A2, membrane associated (NPS-PLA2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Phospholipase A2, membrane associated (NPS-PLA2)

Target (abbrv.) NPS-PLA2
Target (full name) Phospholipase A2, membrane associated
Somalogic ID (Sequence ID) SL002528 (2692-74_2)
Entrez Gene Symbol PLA2G2A
UniProt ID P14555
UniProt Comment
  • Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Targeted by drugs (based on IPA annotation)
  • varespladib methyl
  • varespladib
  • indomethacin
Biomarker applications (based on IPA annotation)
  • efficacy
  • prognosis
  • safety
Wiki Pathways
  • Eicosanoid Synthesis
  • MicroRNAs in cardiomyocyte hypertrophy
Pathway Interaction Database
  • Glypican 1 network
  • Acyl chain remodelling of PC
  • Acyl chain remodelling of PE
  • Acyl chain remodelling of PG
  • Acyl chain remodelling of PI
  • Acyl chain remodelling of PS
  • Synthesis of PA

All locus annotations are based on the sentinel SNP (rs17354650).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • PLA2G5 phospholipase A2, group V
eQTL genes
  • MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
  • OTUD3 OTU deubiquitinase 3


Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (cysteine-glutathione disulfide)/(glycerate) 7.5×10-5 21886157 (PMID) GRASP2 metabQTL
Gene expression of PLA2G5 [probe 2323847] in brain cortex 1.9×10-4 19222302 (PMID) GRASP2 eQTL