HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 308

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
DLRB1 trans Discovery rs3737276 1:248,024,073 A/C 0.28 992 0.361 0.047 3.6×10-14 1.130 3×10-13 7.8×10-6
DLRB1 trans Replication rs3737277 1:248,023,966 G/A 0.22 337 -0.020 0.056 0.726 -1.010 0.835 0.673


Regional association plots

Dynein light chain roadblock-type 1 (DLRB1)


Boxplots and histograms for top associations

Dynein light chain roadblock-type 1 (DLRB1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Dynein light chain roadblock-type 1 (DLRB1)

Target (abbrv.) DLRB1
Target (full name) Dynein light chain roadblock-type 1
Somalogic ID (Sequence ID) SL011530 (3845-51_2)
Entrez Gene Symbol DYNLRB1
UniProt ID Q9NP97
UniProt Comment
  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Pathway Interaction Database
  • TGF-beta receptor signaling
  • Intraflagellar transport

All locus annotations are based on the sentinel SNP (rs3737276) and 9 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • TRIM58 tripartite motif containing 58
eQTL genes
  • OR2W3 olfactory receptor, family 2, subfamily W, member 3
  • TRIM58 tripartite motif containing 58
  • OR2T8 olfactory receptor, family 2, subfamily T, member 8


Results from other genome-wide association studies

Trait P Study Source
Gene expression of OR2W3 in blood 5.3×10-20 21829388 (PMID) GRASP2 eQTL
Gene expression of TRIM58 in blood 6.5×10-13 21829388 (PMID) GRASP2 eQTL