HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 331

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
FCN2 cis Discovery rs2989736 9:137,797,175 G/A 0.44 995 0.324 0.043 1.3×10-13 1.060 5.6×10-12 5×10-8
FCN2 cis Replication rs2989736 9:137,797,175 G/A 0.49 337 0.234 0.071 0.001 1.040 0.002 0.004


Regional association plots


Boxplots and histograms for top associations

Ficolin-2 (FCN2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Ficolin-2 (FCN2)

Target (abbrv.) FCN2
Target (full name) Ficolin-2
Somalogic ID (Sequence ID) SL006542 (3313-21_2)
Entrez Gene Symbol FCN2
UniProt ID Q15485
UniProt Comment
  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
  • Ficolins bind to repetitive carbohydrate structures on the target cell surface
  • Initial triggering of complement
  • Lectin pathway of complement activation

All locus annotations are based on the sentinel SNP (rs2989736).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • FCN1 ficolin (collagen/fibrinogen domain containing) 1


Results from other genome-wide association studies

No associations available.