HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 355

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
GPVI cis Discovery rs11672111 19:55,565,634 G/C 0.10 996 0.514 0.071 6.8×10-13 1.150 4.4×10-12 1.9×10-13
GPVI cis Replication rs11084387 19:55,565,352 G/A 0.10 337 0.099 0.059 0.097 1.080 0.058 0.514


Regional association plots


Boxplots and histograms for top associations

Platelet glycoprotein VI (GPVI)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Platelet glycoprotein VI (GPVI)

Target (abbrv.) GPVI
Target (full name) Platelet glycoprotein VI
Somalogic ID (Sequence ID) SL008759 (3194-36_2)
Entrez Gene Symbol GP6
UniProt ID Q9HCN6
UniProt Comment
  • Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
  • Cell surface interactions at the vascular wall
  • GPVI-mediated activation cascade
  • Platelet Adhesion to exposed collagen

All locus annotations are based on the sentinel SNP (rs11672111) and 21 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes
eQTL genes
  • GP6 glycoprotein VI (platelet)


Results from other genome-wide association studies

Trait P Study Source
lysoPC a C20:4 / PC aa C42:0 1.4×10-8 20037589 (PMID) GRASP2 metabQTL