HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 385

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Siglec-9 cis Discovery rs3745542 19:51,587,643 T/C 0.31 996 0.336 0.048 3.1×10-12 1.910 2×10-11 3.9×10-12
Siglec-9 cis Replication rs2691232 19:51,587,288 C/A 0.24 337 0.021 0.083 0.8 1.080 0.669 0.563


Regional association plots

Sialic acid-binding Ig-like lectin 9 (Siglec-9)


Boxplots and histograms for top associations

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

Target (abbrv.) Siglec-9
Target (full name) Sialic acid-binding Ig-like lectin 9
Somalogic ID (Sequence ID) SL005219 (3007-7_2)
Entrez Gene Symbol SIGLEC9
UniProt ID Q9Y336
UniProt Comment
  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Pathway Studio
  • Natural Killer Cell Inhibitory Receptor Signaling

All locus annotations are based on the sentinel SNP (rs3745542) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • KLK14 kallikrein-related peptidase 14


Results from other genome-wide association studies

Trait P Study Source
cg12683641 (chr19:51587126) 4×10-39 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg25263454 (chr19:51587385) 2.6×10-10 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Cutaneous melanoma (skin cancer) 8.7×10-6 21926416 (PMID) GRASP2 nonQTL