HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 392

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Siglec-9 cis Discovery rs17801525 19:51,615,155 G/A 0.11 997 -0.492 0.070 3.9×10-12 -2.920 2.7×10-14 4.4×10-15
Siglec-9 cis Replication rs12973316 19:51,615,048 G/A 0.26 337 -0.427 0.074 2×10-8 -2.570 2.3×10-9 3.6×10-7


Regional association plots

Sialic acid-binding Ig-like lectin 9 (Siglec-9)


Boxplots and histograms for top associations

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

Target (abbrv.) Siglec-9
Target (full name) Sialic acid-binding Ig-like lectin 9
Somalogic ID (Sequence ID) SL005219 (3007-7_2)
Entrez Gene Symbol SIGLEC9
UniProt ID Q9Y336
UniProt Comment
  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Pathway Studio
  • Natural Killer Cell Inhibitory Receptor Signaling

All locus annotations are based on the sentinel SNP (rs17801525) and 6 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CTU1 cytosolic thiouridylase subunit 1
Potentially regulated genes
  • SHANK1 SH3 and multiple ankyrin repeat domains 1
eQTL genes
  • SIGLEC9 sialic acid binding Ig-like lectin 9


Results from other genome-wide association studies

Trait P Study Source
cg02592403 (chr19:51614886) 9.4×10-137 10.1101/033084 (DOI) BIOS QTL cis-meQTLs