HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 395

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MIP-5 cis Discovery rs2075746 17:34,325,532 C/T 0.44 992 -0.297 0.042 4.3×10-12 -1.100 3.6×10-14 3.8×10-14
MIP-5 cis Replication rs2075746 17:34,325,532 G/A 0.34 337 -0.414 0.068 4.1×10-9 -1.170 1.1×10-9 8×10-9


Regional association plots


Boxplots and histograms for top associations

C-C motif chemokine 15 (MIP-5)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 15 (MIP-5)

Target (abbrv.) MIP-5
Target (full name) C-C motif chemokine 15
Somalogic ID (Sequence ID) SL003190 (3509-1_1)
Entrez Gene Symbol CCL15
UniProt ID Q16663
UniProt Comment
  • Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Pathway Studio
  • CCR1 → STAT signaling
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs2075746).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by


Results from other genome-wide association studies

No associations available.