HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 59

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
RAP trans Discovery rs1622406 6:31,308,862 C/T 0.03 997 2.011 0.112 7.1×10-63 2.800 4.3×10-217 3.2×10-229


Regional association plots

alpha-2-macroglobulin receptor-associated protein (RAP)


Boxplots and histograms for top associations

alpha-2-macroglobulin receptor-associated protein (RAP)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

alpha-2-macroglobulin receptor-associated protein (RAP)

Target (abbrv.) RAP
Target (full name) alpha-2-macroglobulin receptor-associated protein
Somalogic ID (Sequence ID) SL005263 (3640-14_3)
Entrez Gene Symbol LRPAP1
UniProt ID P30533
UniProt Comment
  • Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Pathway Interaction Database
  • Lissencephaly gene (LIS1) in neuronal migration and development
  • Reelin signaling pathway
  • Signaling events mediated by the Hedgehog family

All locus annotations are based on the sentinel SNP (rs1622406) and 17 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.

Linked genes

Genes hit or close-by
Potentially regulated genes


Results from other genome-wide association studies

Trait P Study Source
Height 1.2×10-8 25282103 (PMID) Supplemental file
Crohn's disease 1×10-5 Supplemental file
Hip circumfence, adjusted for BMI 1.7×10-5 25673412 (PMID) Supplemental file
Rheumatoid arthritis 2.2×10-5 20453842 (PMID) GRASP2 nonQTL