HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 68

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
SPARCL1 cis Discovery rs4693167 4:88,423,913 T/C 0.37 997 0.680 0.042 2.6×10-53 1.130 9.3×10-52 4.1×10-50
SPARCL1 cis Replication rs7681694 4:88,462,729 A/G 0.47 337 -0.506 0.060 7.6×10-16 -1.130 1.9×10-15 3.3×10-15


Regional association plots


Boxplots and histograms for top associations

SPARC-like protein 1 (SPARCL1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

SPARC-like protein 1 (SPARCL1)

Target (abbrv.) SPARCL1
Target (full name) SPARC-like protein 1
Somalogic ID (Sequence ID) SL005488 (4467-49_2)
Entrez Gene Symbol SPARCL1
UniProt ID Q14515
UniProt Comment
  • Secreted
Biomarker applications (based on IPA annotation)
  • disease progression

All locus annotations are based on the sentinel SNP (rs4693167) and 36 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes
eQTL genes
  • SPARCL1 SPARC-like 1 (hevin)
  • NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
  • HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
  • HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13
  • PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K
  • RP11-529H2.2


Results from other genome-wide association studies

Trait P Study Source
Gene expression of S73397 in liver 4.3×10-5 18462017 (PMID) GRASP2 eQTL
Differential exon level expression of SPARCL1 [probe 2777142] in brain cortex 4.7×10-5 19222302 (PMID) GRASP2 eQTL
Gene expression of SPARCL1 in liver 8.3×10-5 18462017 (PMID) GRASP2 eQTL
Gene expression of DHRS8 in blood 9×10-5 21829388 (PMID) GRASP2 eQTL
Gene expression of NUDT9 in blood 4.3×10-4 21829388 (PMID) GRASP2 eQTL