HelmholtzZentrum munich

Connecting genetic risk to disease endpoints through the human blood plasma proteome


Proteome annotation
Locus annotations

Locus 99

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Gro-a cis Discovery rs16845091 4:74,758,801 G/T 0.05 997 1.237 0.090 1.6×10-39 1.830 4.4×10-50 1×10-41
Gro-a cis Replication rs74544699 4:74,734,681 A/G 0.10 337 0.644 0.095 5.6×10-11 1.560 8.2×10-11 0.189


Regional association plots

Growth-regulated alpha protein (Gro-a)


Boxplots and histograms for top associations

Growth-regulated alpha protein (Gro-a)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Growth-regulated alpha protein (Gro-a)

Target (abbrv.) Gro-a
Target (full name) Growth-regulated alpha protein
Somalogic ID (Sequence ID) SL003173 (2985-35_1)
Entrez Gene Symbol CXCL1
UniProt ID P09341
UniProt Comment
  • Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Biomarker applications (based on IPA annotation)
  • disease progression
Wiki Pathways
  • Cytokines and Inflammatory Response
  • Senescence and Autophagy
Pathway Interaction Database
  • IL23-mediated signaling events
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
Pathway Studio
  • IL8R → CREB/EGR signaling

All locus annotations are based on the sentinel SNP (rs16845091) and 53 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
  • HNRNPA1P55 heterogeneous nuclear ribonucleoprotein A1 pseudogene 55
  • CXCL1P chemokine (C-X-C motif) ligand 1 pseudogene
Potentially regulated genes
eQTL genes
  • PF4 platelet factor 4
  • CXCL6 chemokine (C-X-C motif) ligand 6


Results from other genome-wide association studies

Trait P Study Source
Gene expression of PF4V1 in peripheral blood monocytes 2.7×10-8 20502693 (PMID) GRASP2 eQTL
Gene expression of GAL3ST2 in peripheral blood monocytes 5.8×10-6 20502693 (PMID) GRASP2 eQTL
Serum ratio of (1-eicosatrienoylglycerophosphocholine*)/(biliverdin) 2.2×10-5 21886157 (PMID) GRASP2 metabQTL