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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 105

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICB cis Discovery rs3094005 6:31,465,047 G/T 0.09 996 -0.931 0.069 4.2×10-38 -1.310 3×10-13 0.19
MICB cis Replication rs3099844 6:31,448,976 C/A 0.06 337 -0.711 0.132 1.3×10-7 -1.310 2.1×10-5 0.092

 

Regional association plots

MHC class I polypeptide-related sequence B (MICB)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence B (MICB)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

MHC class I polypeptide-related sequence B (MICB)

Target (abbrv.) MICB
Target (full name) MHC class I polypeptide-related sequence B
Somalogic ID (Sequence ID) SL005200 (5102-55_3)
Entrez Gene Symbol MICB
UniProt ID Q29980
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs3094005) and 120 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes
eQTL genes
  • C4A complement component 4A (Rodgers blood group)
  • HLA-C major histocompatibility complex, class I, C
  • XXbac-BPG248L24.13
  • STK19B serine/threonine kinase 19B, pseudogene
  • HLA-B major histocompatibility complex, class I, B
  • CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
  • MICB MHC class I polypeptide-related sequence B
  • VARS2 valyl-tRNA synthetase 2, mitochondrial
  • FLOT1 flotillin 1
  • C4B complement component 4B (Chido blood group)
  • XXbac-BPG248L24.12
  • CCHCR1 coiled-coil alpha-helical rod protein 1
  • PPP1R18 protein phosphatase 1, regulatory subunit 18
  • WASF5P WAS protein family, member 5, pseudogene
  • CYP21A1P cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene
  • LINC00243
  • PSORS1C1 psoriasis susceptibility 1 candidate 1
  • HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
  • HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
  • PSORS1C2 psoriasis susceptibility 1 candidate 2
  • HCP5 HLA complex P5 (non-protein coding)
  • OR5V1 olfactory receptor, family 5, subfamily V, member 1
  • IER3 immediate early response 3
  • HCG22 HLA complex group 22
  • STK19 serine/threonine kinase 19
  • NOTCH4 notch 4
  • LY6G6C lymphocyte antigen 6 complex, locus G6C
  • RNF5 ring finger protein 5, E3 ubiquitin protein ligase
  • TMEM154 transmembrane protein 154
  • HIST1H2BD histone cluster 1, H2bd
  • CSF3R colony stimulating factor 3 receptor (granulocyte)
  • TNXA tenascin XA (pseudogene)
  • XXbac-BPG252P9.10
  • SNORD84 small nucleolar RNA, C/D box 84
  • DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
  • C6orf10 chromosome 6 open reading frame 10
  • HLA-G major histocompatibility complex, class I, G
  • BTN3A2 butyrophilin, subfamily 3, member A2
  • HLA-DPB1 major histocompatibility complex, class II, DP beta 1
  • MICA MHC class I polypeptide-related sequence A
  • LST1 leukocyte specific transcript 1
  • SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)

 

Results from other genome-wide association studies

Trait P Study Source
cg17862947 (chr12:133086950) 7×10-232 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01620082 (chr3:125678431) 1.5×10-231 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg06606381 (chr12:133084921) 1.5×10-224 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Myasthenia gravis 2.6×10-110 23055271 (PMID) GRASP2 nonQTL
Type 1 diabetes, combined control dataset 2.2×10-79 17554300 (PMID) GRASP2 nonQTL
Idiopathic membranous nephropathy 6×10-72 21323541 (PMID) GWAS Catalog via SNiPA
cg17841099 (chr1:153940066) 3.8×10-69 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Diabetes mellitus, type 1 5.3×10-68 pha002862 (dbGaP) dbGaP via SNiPA
cg02753903 (chr19:38943549) 1.3×10-66 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01255021 (chr16:1094629) 7.4×10-60 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Primary sclerosing cholangitis 6.8×10-49 21151127 (PMID) GRASP2 nonQTL
Gene expression of HLA-DRB4 in peripheral blood monocytes 6.9×10-44 20502693 (PMID) GRASP2 eQTL
cg06099246 (chr16:1094837) 4.7×10-37 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23656755 (chr1:230203067) 1.5×10-36 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22379212 (chr19:38944024) 3.8×10-35 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg00624589 (chr16:1094766) 2.3×10-32 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18651192 (chr3:125677598) 3.6×10-31 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg15007120 (chr3:109128526) 8.3×10-27 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of VARSL in blood 1.1×10-26 21829388 (PMID) GRASP2 eQTL
Gene expression of BTN3A2 in peripheral blood monocytes 9.5×10-26 20502693 (PMID) GRASP2 eQTL
cg19808620 (chr1:153514466) 2.2×10-25 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12321149 (chr20:57427402) 2.6×10-23 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg19589727 (chr20:57427786) 4×10-23 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB1 in peripheral blood monocytes 1.8×10-22 20502693 (PMID) GRASP2 eQTL
cg01817393 (chr20:57427618) 3×10-22 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Height 5.4×10-22 25282103 (PMID) Supplemental file
Gene expression of HLA-B in lymphoblastoid cell lines 4.9×10-21 18193047 (PMID) GRASP2 eQTL
cg14564778 (chr20:57427532) 6.1×10-21 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27661264 (chr20:57427762) 1.1×10-20 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg06065549 (chr20:57427419) 3.3×10-20 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Schizophrenia 3.9×10-20 25056061 (PMID) Supplemental file
cg25652859 (chr20:57427388) 5.5×10-20 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in temporal cortex in Alzheimer's disease cases and controls 5.9×10-20 22685416 (PMID) GRASP2 eQTL
cg19640589 (chr20:57427997) 6.1×10-20 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in cerebellum in Alzheimer's disease cases and controls 9.1×10-20 22685416 (PMID) GRASP2 eQTL
cg20528838 (chr20:57427754) 9.2×10-20 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10302550 (chr20:57427845) 1.8×10-19 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17414107 (chr20:57427854) 1.8×10-19 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQA1 in peripheral blood monocytes 4.9×10-19 20502693 (PMID) GRASP2 eQTL
cg04257105 (chr20:57427689) 1.1×10-17 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04571189 (chr2:10638048) 1.4×10-17 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg20495738 (chr12:2338423) 1.6×10-17 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03708907 (chr19:38943310) 2.1×10-17 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Total cholesterol 2.6×10-17 24097068 (PMID) Supplemental file
cg00943909 (chr20:57427966) 4.5×10-17 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQB1 in peripheral blood monocytes 4.6×10-17 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-DPB1 in peripheral blood monocytes 6.7×10-17 20502693 (PMID) GRASP2 eQTL
Type 1 diabetes 1×10-16 17632545 (PMID) GRASP2 nonQTL
cg22157027 (chr2:10638089) 1×10-16 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03908391 (chr20:57427194) 1.6×10-16 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22322277 (chr6:75459134) 1.9×10-16 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg26534489 (chr20:57427519) 1.2×10-15 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of [probe 580452 centered at chr6:31558910] in blood 1.4×10-15 21829388 (PMID) GRASP2 eQTL
Lupus erythematosus, systemic 4×10-15 pha002848 (dbGaP) dbGaP via SNiPA
Triglycerides 4.4×10-15 24097068 (PMID) Supplemental file
Gene expression of [probe 1440603 centered at chr6:31556036] in blood 6.2×10-15 21829388 (PMID) GRASP2 eQTL
Gene expression of XRCC6 in blood 6.3×10-15 21829388 (PMID) GRASP2 eQTL
cg20954971 (chr21:44593666) 8.8×10-15 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB1 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC731718 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 221491_x_at] in lymphoblastoid cell lines 1.2×10-14 17873877 (PMID) GRASP2 eQTL
cg04788957 (chr10:105438032) 2×10-14 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07105596 (chr20:57427496) 3.8×10-14 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-G in peripheral blood monocytes 3.8×10-14 20502693 (PMID) GRASP2 eQTL
cg01970336 (chr1:51986230) 5.8×10-14 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQA1 [probe 203290_at] in lymphoblastoid cell lines 6.8×10-14 17873877 (PMID) GRASP2 eQTL
cg26811638 (chr20:57427517) 1.7×10-13 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07575812 (chr5:138883534) 4.2×10-13 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of TMEM154 in blood 9.1×10-13 21829388 (PMID) GRASP2 eQTL
Gene expression of VARS2 in peripheral blood monocytes 1.1×10-12 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-A in peripheral blood monocytes 1.2×10-12 20502693 (PMID) GRASP2 eQTL
cg02471183 (chr8:67456707) 1.5×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg19313311 (chr7:74058055) 1.6×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07441944 (chr11:44623435) 2×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Lung cancer 2.1×10-12 22899653 (PMID) GRASP2 nonQTL
cg01017090 (chr20:57427022) 2.1×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg14066773 (chr19:2234238) 2.8×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23331010 (chr3:98512714) 3.2×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10213762 (chr6:169284343) 4.1×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12494529 (chr10:1082456) 4.2×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10129154 (chr16:1093799) 4.2×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24854010 (chr12:1726057) 6.1×10-12 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB1 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 204670_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
cg05983405 (chr10:72360324) 1.1×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03010274 (chr20:57427250) 1.7×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg09208331 (chr21:44864028) 1.8×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02575092 (chr17:77100211) 1.9×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07856962 (chr21:44864337) 2.2×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27321311 (chr19:38943444) 2.4×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08431893 (chr21:44864576) 3.4×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08477528 (chr11:117651193) 3.6×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10154826 (chr6:17601018) 3.7×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24149237 (chr11:117687604) 4.3×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQB1 [probe 209480_at] in lymphoblastoid cell lines 4.3×10-11 17873877 (PMID) GRASP2 eQTL
cg09610018 (chr2:121433098) 5×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in cerebellum in non-Alzheimer's disease samples 5.4×10-11 22685416 (PMID) GRASP2 eQTL
cg01021742 (chr17:77100156) 6.3×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg05277504 (chr17:79961638) 7.4×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08127462 (chr1:153514240) 8.9×10-11 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07408552 (chr17:40612019) 1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg16017144 (chr17:77100106) 1.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in temporal cortex in non-Alzheimer's disease samples 1.3×10-10 22685416 (PMID) GRASP2 eQTL
cg12342742 (chr11:64835016) 1.6×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04010868 (chr16:11876357) 1.8×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22290117 (chr20:57427197) 1.8×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08065963 (chr16:8985569) 2.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23052776 (chr14:71609182) 2.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24510518 (chr8:144358922) 2.7×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12800105 (chr12:121972436) 3.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in temporal cortex in Alzheimer's disease cases 3.2×10-10 22685416 (PMID) GRASP2 eQTL
cg12550496 (chr6:169284320) 3.3×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg05946118 (chr16:8985614) 3.7×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22572158 (chr2:204731092) 3.8×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of APOM in peripheral blood monocytes 3.9×10-10 20502693 (PMID) GRASP2 eQTL
Cardiac neonatal lupus 4.5×10-10 20662065 (PMID) GRASP2 nonQTL
cg16521555 (chr1:25069110) 4.6×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17372758 (chr10:73976774) 4.9×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Neonatal lupus 5×10-10 20662065 (PMID) GWAS Catalog via SNiPA
cg14407667 (chr1:51985233) 5.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04444027 (chr16:8986068) 5.8×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10696062 (chr12:1726004) 6.2×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12011479 (chr19:51873021) 6.7×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQB1 [probe 212999_x_at] in lymphoblastoid cell lines 7.1×10-10 17873877 (PMID) GRASP2 eQTL
cg14647944 (chr9:73095764) 7.2×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg21333217 (chr3:129277297) 8.1×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg14825413 (chr8:144358590) 9.3×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB1 in lymphoblastoid cell lines 9.6×10-10 17873877 (PMID) GRASP2 eQTL
cg07992484 (chr2:106724137) 9.7×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10246083 (chr1:210589659) 9.9×10-10 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Psoriasis 1×10-9 18364390 (PMID) GRASP2 nonQTL
Gene expression of HLA-DRB4 in liver 1×10-9 22006096 (PMID) GRASP2 eQTL
cg25994622 (chr19:15582751) 1.1×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27110054 (chr8:103137250) 1.1×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Allopurinol-related Stevens-Johnson syndrome or toxic epidermal necrolysis 1.3×10-9 21912425 (PMID) GRASP2 nonQTL
cg14153654 (chr1:8001003) 1.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01300291 (chr3:194980373) 1.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C (probeID ILMN_2150787) in cerebellum in Alzheimer's disease cases 1.5×10-9 22685416 (PMID) GRASP2 eQTL
cg10894072 (chr1:51985239) 1.7×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg09222732 (chr6:466917) 1.8×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18810022 (chr2:134989787) 2×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg09244071 (chr7:101768722) 2.2×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQA1 [probe 213831_at] in lymphoblastoid cell lines 2.4×10-9 17873877 (PMID) GRASP2 eQTL
cg11828203 (chr7:31014738) 2.8×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg10986849 (chr2:206750559) 3×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg26496204 (chr20:57427186) 3×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-A29.1 in peripheral blood monocytes 3.2×10-9 20502693 (PMID) GRASP2 eQTL
cg03473640 (chr15:52601085) 3.2×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27309098 (chr2:236619772) 3.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27304369 (chr20:57427507) 3.5×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12771187 (chr7:116152034) 3.8×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08766149 (chr14:25103325) 5.7×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg16986494 (chr3:61237230) 6.2×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg25381331 (chr1:53556390) 7.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg15004405 (chr5:140890742) 7.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22354132 (chr1:55273613) 8.3×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23685969 (chr10:73976845) 8.4×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24137511 (chr19:18260306) 8.5×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-C [probe 216526_x_at] in lymphoblastoid cell lines 9×10-9 17873877 (PMID) GRASP2 eQTL
Rheumatoid arthritis (ACPA-negative) 9×10-9 24532677 (PMID) GWAS Catalog via SNiPA
cg19635644 (chr13:100007301) 9.5×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27050612 (chr17:46133222) 9.9×10-9 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB3 in peripheral blood monocytes 1×10-8 20502693 (PMID) GRASP2 eQTL
cg01955533 (chr6:36650709) 1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18800235 (chr1:94486871) 1.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22664798 (chr10:134750191) 1.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12736501 (chr2:121433194) 1.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08629884 (chr4:1719959) 1.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg25251204 (chr11:14927432) 1.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg19041006 (chr19:57349703) 1.3×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12111500 (chr21:44863986) 1.6×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
HDL in metabolic styndrome subjects without diabetes 1.7×10-8 22399527 (PMID) GRASP2 nonQTL
cg23290159 (chr5:150474258) 1.7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQB1 [probe 211654_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB1 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 209312_x_at] in lymphoblastoid cell lines 1.9×10-8 17873877 (PMID) GRASP2 eQTL
cg21197594 (chr9:140657005) 2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Metabolic syndrome 2×10-8 22399527 (PMID) GWAS Catalog via SNiPA
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) 2×10-8 21912425 (PMID) GWAS Catalog via SNiPA
cg24313592 (chr11:72020055) 2.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07520269 (chr11:84634212) 2.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08621441 (chr1:1267721) 2.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03407631 (chr6:52998845) 2.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03438618 (chr10:134748651) 2.5×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg05861291 (chr2:207987514) 2.7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02892367 (chr7:148724117) 2.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg12226095 (chr4:27057978) 2.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17329534 (chr1:154980719) 2.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27443779 (chr11:14664769) 3×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18500714 (chr14:100706312) 3×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07896667 (chr12:1726100) 3.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg11170796 (chr19:1650200) 3.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Lymphocyte count 3.3×10-8 19853236 (PMID) GRASP2 nonQTL
cg03914707 (chr7:14031092) 3.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08823182 (chr1:153514458) 3.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27663123 (chr14:91853658) 3.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02976539 (chr17:72757278) 3.6×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DQB1 in lymphoblastoid cell lines 3.8×10-8 17873877 (PMID) GRASP2 eQTL
cg08888178 (chr19:345005) 3.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02188939 (chr17:1509859) 3.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg26853265 (chr19:15582829) 4.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of PSMB9 in peripheral blood monocytes 4.1×10-8 20502693 (PMID) GRASP2 eQTL
cg08779649 (chr13:50194530) 4.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg00624799 (chr15:90605594) 4.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07309864 (chr17:73238465) 4.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg15013801 (chr10:73976814) 4.4×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24311485 (chr7:73181133) 4.7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg26712743 (chr10:100164618) 4.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg11987853 (chr13:113832545) 5.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18310515 (chr2:85921505) 5.5×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17769836 (chr19:45445413) 5.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22900360 (chr10:72360348) 5.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg06706159 (chr19:18260326) 6×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02964724 (chr11:2292337) 6.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of AL645933.8 in blood 6.2×10-8 21829388 (PMID) GRASP2 eQTL
cg22110158 (chr11:130036566) 6.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg13506158 (chr3:191048401) 6.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17467525 (chr1:9686499) 6.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01511567 (chr11:57103655) 6.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22857963 (chr8:144358067) 6.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01994290 (chr14:65170025) 7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg22455527 (chr7:73241902) 7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01500140 (chr19:51890610) 7.1×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg15621458 (chr12:97300453) 7.9×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg00479463 (chr19:33726762) 8.2×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg00962793 (chr14:104852665) 8.3×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg17211761 (chr17:1096650) 9.7×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02107163 (chr2:241500067) 9.8×10-8 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24673600 (chr14:76005953) 1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg11115622 (chr14:65169934) 1.1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08612539 (chr22:37257100) 1.1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg20116138 (chr13:113229358) 1.1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg14098951 (chr5:176875144) 1.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg08447520 (chr12:113513050) 1.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03231471 (chr11:120811346) 1.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg03731797 (chr19:42900516) 1.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02556649 (chr11:1945540) 1.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg13424923 (chr2:65258762) 1.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg21858462 (chr13:112628472) 1.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01501551 (chr14:74100836) 1.4×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01877524 (chr11:117651335) 1.4×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg00254133 (chr20:61340566) 1.4×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg25315312 (chr7:2020504) 1.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg27630771 (chr1:150533099) 1.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23015664 (chr7:2040133) 1.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07599389 (chr6:4890302) 1.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04746089 (chr8:145501886) 1.6×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02695567 (chr10:134728512) 1.6×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg24929556 (chr1:167454852) 1.7×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg02580045 (chr12:110449247) 1.7×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg18156192 (chr1:112320857) 1.8×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HLA-DRB5 in peripheral blood monocytes 1.8×10-7 20502693 (PMID) GRASP2 eQTL
cg20657709 (chr2:28509594) 1.8×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Bipolar disorder vs. Schizophrenia 1.9×10-7 24280982 (PMID) Supplemental file
Gene expression of ZFP57 in peripheral blood monocytes 1.9×10-7 20502693 (PMID) GRASP2 eQTL
Lung function, forced expiratory volume in 1 second (FEV1) 1.9×10-7 21946350 (PMID) GRASP2 nonQTL
cg03984502 (chr1:151805637) 1.9×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg09003057 (chr14:91853704) 1.9×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg14496375 (chr19:51872389) 2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg13942103 (chr1:111177805) 2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04392554 (chr22:46685448) 2.1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg23214764 (chr11:86511186) 2.1×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg06430509 (chr21:44853494) 2.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg21217270 (chr1:25238247) 2.2×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg19051213 (chr2:128281310) 2.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg01717524 (chr1:120204904) 2.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg13775629 (chr10:72360424) 2.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg06588802 (chr2:8422260) 2.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg26575057 (chr6:170606530) 2.3×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Gene expression of HCP5 in peripheral blood monocytes 2.4×10-7 20502693 (PMID) GRASP2 eQTL
cg02811473 (chr20:37462498) 2.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg04352288 (chr16:87958383) 2.5×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg07759394 (chr11:134201930) 2.6×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
cg14058851 (chr6:15505925) 2.6×10-7 10.1101/033084 (DOI) BIOS QTL trans-meQTLs
Hematology traits 5×10-7 23263863 (PMID) GWAS Catalog via SNiPA
White blood cell count (WBC) 5.5×10-7 23263863 (PMID) GRASP2 nonQTL
Sarcoidosis 6.8×10-7 22952805 (PMID) GRASP2 nonQTL
Rheumatoid arthritis 6.9×10-7 20453842 (PMID) GRASP2 nonQTL
Alopecia areata 9.5×10-7 22027810 (PMID) GRASP2 nonQTL
HIV-1 control (viral load at set point) 1.1×10-6 20041166 (PMID) GRASP2 nonQTL
Cross-disorder, subset Schizophrenia 1.4×10-6 23453885 (PMID) Supplemental file
Differential exon level expression of HLA-B [probe 2948952] in peripheral blood mononuclear cells 2.3×10-6 19222302 (PMID) GRASP2 eQTL
Gene expression of HLA-C in peripheral blood monocytes 2.7×10-6 20502693 (PMID) GRASP2 eQTL
Differential exon level expression of HLA-C [probe 2948915] in peripheral blood mononuclear cells 3×10-6 19222302 (PMID) GRASP2 eQTL
Gene expression of HLA-C (probeID ILMN_6270326) in whole blood 5.1×10-6 22692066 (PMID) GRASP2 eQTL
Gene expression of HLA-DMA in peripheral blood monocytes 5.8×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-B in peripheral blood monocytes 6.2×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of MICA in normal prepouch ileum 7.3×10-6 23474282 (PMID) GRASP2 eQTL
HDL cholesterol 8.4×10-6 24097068 (PMID) Supplemental file
Gene expression of LY6G6D in Lymphoblastoid cell lines 1.3×10-5 19644074 (PMID) GRASP2 eQTL
Waist-to-hip ratio, adjusted for BMI 2.5×10-5 25673412 (PMID) Supplemental file
Airflow obstruction 2.6×10-5 22837378 (PMID) GRASP2 nonQTL
Crohn's disease 3.6×10-5 Supplemental file
Gene expression of MICA (probeID ILMN_1797929) in temporal cortex in Alzheimer's disease cases and controls 3.9×10-5 22685416 (PMID) GRASP2 eQTL
LDL cholesterol 5.6×10-5 24097068 (PMID) Supplemental file
Gene expression of VARS2 in normal prepouch ileum 7.3×10-5 23474282 (PMID) GRASP2 eQTL
laurylcarnitine 7.9×10-5 24816252 (PMID) gwas.eu via SNiPA
Lung function, ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) (FEV1/FVC) 7.9×10-5 20010835 (PMID) GRASP2 nonQTL
Smoking behaviour, Former smoker 8.1×10-5 20418890 (PMID) Supplemental file
Asthma 1.1×10-4 20860503 (PMID) GRASP2 nonQTL
Breast neoplasms 1.6×10-4 pha002853 (dbGaP) dbGaP via SNiPA
Gene expression of AIF1 in blood 1.9×10-4 21829388 (PMID) GRASP2 eQTL
Waist-to-hip ratio 1.9×10-4 25673412 (PMID) Supplemental file