pGWAS server

Click on a locus number to open the annotations for this locus. You can filter the list using the "Search" box. However, if you are not looking for a specific locus, sentinel SNP, or candidate gene, we recommend using the full text search instead.

Top: strongest SNP-target association on this locus. Candidate genes: protein coding genes, immunoglobulin genes, T-cell receptor genes, and translated pseudogenes that are connected to a set of variants (sentinel SNPs and proxies in LD r² ≥ 0.8). These variants may be located on or in close proximity to a gene (a), have potential regulatory effects on a gene (b), modify the expression of a gene (cis-eQTL = c; trans-eQTL = d), or cause an amino acid exchange in the encoded protein (e). Candidate genes annotations based on SNiPA's block annotation. Replicable: SNP-target association is expected to replicate with 95% power (see manuscript's Online Methods). Replicated: SNP-target association is nominal significant (P<1.08×10^-4) in the replication cohort. Targeted by drugs/biomarker applications annotations are based on Ingenuity Pathway Analysis.

Locus	Target	Candidate genes	SNP	P_inv	Targeted by drugs	Biomarker applications
1 Top	sICAM-1 (cis) Intercellular adhesion molecule 1	ICAM4^abc, ICAM5^ac, ICAM1^ae, ZGLP1^b, TYK2^b [3 more]KRI1^b, PPAN^b, P2RY11^b	rs5498 19:10,395,683	7.7×10^-267 replicable replicated		diagnosis, efficacy, prognosis, unspecified application
1	sICAM-5 (cis) Intercellular adhesion molecule 5	ICAM4^abc, ICAM5^ac, ICAM1^ae, ZGLP1^b, TYK2^b [3 more]KRI1^b, PPAN^b, P2RY11^b	rs5498 19:10,395,683	2.4×10^-32 replicable replicated
2 Top	IL-6 sRa (cis) Interleukin-6 receptor subunit alpha	IL6R^abc, C1orf189^b, UBAP2L^b, AQP10^c, UBE2Q1^c	rs4129267 1:154,426,264	1.6×10^-265 replicable replicated	tocilizumab	efficacy
3 Top	PPAC (cis) Low molecular weight phosphotyrosine protein phosphatase	ACP1^abce, SH3YL1^abc, FAM150B^a	rs11553746 2:272,203	1.1×10^-257 replicable replicated
4 Top	MSP (cis) Hepatocyte growth factor-like protein	MST1^abce, AMT^abc, APEH^abc, BSN^abe, GPX1^ace [29 more]	rs9858542 3:49,701,983	1.4×10^-242 replicable replicated
5 Top	sLeptin R (cis) Leptin receptor	LEPR^ae	rs17415296 1:66,099,013	4.5×10^-229 replicable replicated	recombinant-methionyl human leptin	prognosis
6 Top	IL-1 R AcP (cis) Interleukin-1 Receptor accessory protein	IL1RAP^a	rs1024948 3:190,347,681	2.5×10^-165 replicable replicated
7 Top	Siglec-3 (cis) Myeloid cell surface antigen CD33	CD33^ace, SIGLEC12^b, SIGLECL1^c	rs12459419 19:51,728,477	2.9×10^-165 replicable replicated	arsenic trioxide/gemtuzumab ozogamicin/tretinoin, gemtuzumab ozogamicin	efficacy
8 Top	MAPKAPK3 (trans) MAP kinase-activated protein kinase 3	ZC3H13^ae, CPB2^ae, LCP1^c	rs1926447 13:46,629,944	2.2×10^-145 replicable replicated		unspecified application
8	MIF (trans) Macrophage migration inhibitory factor	ZC3H13^ae, CPB2^ae, LCP1^c	rs1926447 13:46,629,944	1×10^-12		diagnosis, prognosis, response to therapy
9 Top	Cripto (cis) Teratocarcinoma-derived growth factor 1	LRRC2^abc, TDGF1^ac, PRSS50^b, LTF^b, CCR2^b [1 more]ALS2CL^c	rs3806701 3:46,617,337	3.8×10^-145 replicable replicated		diagnosis
10 Top	FCG2A/B (cis) Low affinity immunoglobulin gamma Fc region receptor II-a/b	FCGR2B^ac, FCGR3B^c, FCRLB^c	rs17413015 1:161,644,811	9.2×10^-137 replicable replicated
11 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	ERAP1^ac, ERAP2^c, LNPEP^c	rs26496 5:96,137,882	6.4×10^-123 replicable replicated
12 Top	Gro-a (cis) Growth-regulated alpha protein	CXCL1^a, EREG^b, MTHFD2L^b, CXCL6^b, AFM^b [1 more]PF4V1^c	rs3117600 4:74,731,812	3.2×10^-120 replicable replicated		disease progression
13 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICA^abc, VARS2^b, PSORS1C2^c, HLA-C^c, HLA-B^c [6 more]	rs2844511 6:31,389,784	3.8×10^-119 replicable replicated		safety
14 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	ERAP1^abce, CAST^ac, LIX1^b, ERAP2^b, LNPEP^b	rs17482078 5:96,118,866	3×10^-115 replicable replicated
15 Top	PDGF Rb (cis) Platelet-derived growth factor receptor beta	PDGFRB^ac, CDX1^c, CSF1R^c	rs3776081 5:149,532,107	3.3×10^-113 replicable replicated	nilotinib, dasatinib, sunitinib, pazopanib, axitinib, tivozanib, tandutinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, imatinib, sorafenib, becaplermin	prognosis, response to therapy, unspecified application
16 Top	FCG2A/B (cis) Low affinity immunoglobulin gamma Fc region receptor II-a/b	FCGR2A^abe, SDHC^c	rs7551957 1:161,470,042	2.2×10^-111 replicable replicated
17 Top	CAMK1 (trans) Calcium/calmodulin-dependent protein kinase type 1	F5^ae, SELP^b, SELL^b	rs4525 1:169,511,734	2×10^-110 replicable replicated
18 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	FAM200B^abce, FBXL5^abc, BST1^abe, CC2D2A^a, FGFBP2^b [2 more]C1QTNF7^b, CD38^c	rs2302465 4:15,709,192	1.4×10^-108 replicable replicated
19 Top	IL-18 Ra (cis) Interleukin-18 receptor 1	IL18R1^abc, IL1RL1^abc, IL18RAP^abc, SLC9A4^abc, IL1R2^b [4 more]	rs2058622 2:102,985,424	9×10^-108 replicable replicated
20 Top	Chitotriosidase-1 (cis)	CHIT1^ac, ADORA1^c	rs12141375 1:203,181,362	9.3×10^-108 replicable replicated		efficacy
21 Top	PCSK7 (cis) Proprotein convertase subtilisin/kexin type 7	TAGLN^abc, PCSK7^abc, PAFAH1B2^ac, SIDT2^ac, SIK3^b [1 more]CBLN2^d	rs9326248 11:116,999,225	1.7×10^-105 replicable replicated		unspecified application
22 Top	SAA (cis) Serum amyloid A-1 protein	SAA1^abc, TSG101^b, PTPN5^b, HPS5^b, SAA2^c [2 more]SAA2-SAA4^c, GTF2H1^c	rs1993373 11:18,280,635	2.2×10^-105 replicable replicated		diagnosis, unspecified application
23 Top	ADAMTS-5 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 5	ADAMTS5^ae	rs2830585 21:28,305,212	3.9×10^-104 replicable replicated
24 Top	ECM1 (cis) Extracellular matrix protein 1	ECM1^ace, MRPS21^ac, RPRD2^ac, TARS2^ac, AC242988.1^a [8 more]	rs13294 1:150,484,987	7.7×10^-102 replicable replicated		diagnosis
25 Top	GCP-2 (cis) C-X-C motif chemokine 6	CXCL6^ac, PF4V1^c	rs16850073 4:74,703,999	9.7×10^-98 replicable replicated		unspecified application
26 Top	Kininogen, HMW (cis) Kininogen-1	KNG1^ae	rs2304456 3:186,445,052	2.9×10^-97 replicable replicated
26	LCMT1 (trans) Leucine carboxyl methyltransferase 1	KNG1^ae	rs2304456 3:186,445,052	1.4×10^-10 replicated
27 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a	rs2097326 22:33,165,020	4.4×10^-97 replicable replicated		diagnosis, prognosis, unspecified application
28 Top	sE-Selectin (trans) E-Selectin	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	1.2×10^-96 replicable replicated		diagnosis, disease progression, efficacy, unspecified application
28	IR (trans) Insulin receptor	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	3.9×10^-44 replicable replicated	insulin detemir, INS, canakinumab/INS, insulin aspart/insulin detemir, ceritinib, insulin glargine/insulin lispro, insulin aspart, insulin glulisine, insulin lispro, insulin glargine, protamine zinc insulin	prognosis
28	VEGF sR3 (trans) Vascular endothelial growth factor receptor 3	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	1.1×10^-31 replicable replicated	sunitinib, pazopanib, axitinib, CEP 7055, tivozanib, motesanib, telatinib, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, sorafenib, vandetanib	diagnosis, disease progression, efficacy, prognosis
28	CD36 ANTIGEN (trans) Platelet glycoprotein 4	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	1.3×10^-29 replicable		efficacy
28	Endoglin (cis)	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	6×10^-26 replicable		disease progression, efficacy
28	Met (trans) Hepatocyte growth factor receptor	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	3.3×10^-19 replicable replicated	crizotinib, tivantinib, cabozantinib, INC280, cabozantinib/erlotinib	diagnosis, disease progression, efficacy, prognosis, response to therapy, unspecified application
28	sICAM-2 (trans) Intercellular adhesion molecule 2	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	7.5×10^-15
28	VEGF sR2 (trans) Vascular endothelial growth factor receptor 2	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	3.1×10^-13 replicated	AEE 788, sunitinib, cediranib, pazopanib, axitinib, XL647, CEP 7055, brivanib alaninate, CHIR-265, tivozanib, motesanib, OSI-930, telatinib, ramucirumab, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, docetaxel/ramucirumab, vatalanib, sorafenib, vandetanib, pegaptanib	disease progression, efficacy, prognosis, response to therapy, safety
28	ST4S6 (trans) Carbohydrate sulfotransferase 15	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	6.7×10^-13
28	P-Selectin (trans)	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	7.4×10^-13 replicated		efficacy, safety, unspecified application
28	TLR4:MD-2 complex (trans) Toll-like receptor 4:Lymphocyte antigen 96 complex	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	3.4×10^-12
28	Cadherin-5 (trans)	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	4.8×10^-12		diagnosis
28	JAG1 (trans) Protein jagged-1	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	4.7×10^-11		efficacy
28	OX2G (trans) OX-2 membrane glycoprotein	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	8×10^-11 replicated
28	CD109 (trans) CD109 antigen	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [3 more]SURF1^c, SURF6^c, GBGT1^c	rs651007 9:136,153,875	8.4×10^-9
29 Top	C1-Esterase Inhibitor (cis) Plasma protease C1 inhibitor	SERPING1^abe, YPEL4^bc, ZDHHC5^bc, RP11-872D17.8^b, PRG2^b [7 more]	rs11603020 11:57,374,332	5×10^-96 replicable replicated
30 Top	HCC-4 (cis) C-C motif chemokine 16	CCL16^a, CCL14^a, CCL15-CCL14^a	rs33995560 17:34,303,771	1.9×10^-95 replicable replicated
31 Top	HRG (cis) Histidine-rich glycoprotein	HRG^ae	rs2228243 3:186,395,113	4.7×10^-94 replicable replicated
31	MP2K4 (trans) Dual specificity mitogen-activated protein kinase kinase 4	HRG^ae	rs2228243 3:186,395,113	4.2×10^-82 replicable replicated
31	CD27 (trans) CD27 antigen	HRG^ae	rs2228243 3:186,395,113	1.7×10^-45 replicable		unspecified application
31	Semaphorin 3A (trans) Semaphorin-3A	HRG^ae	rs2228243 3:186,395,113	3.3×10^-10
32 Top	IL-17 sR (cis) Interleukin-17 receptor A	IL17RA^ac, CECR6^a	rs3827278 22:17,595,915	2×10^-93 replicable replicated
33 Top	MIP-5 (cis) C-C motif chemokine 15	CCL15^ab, CCL15-CCL14^a, CCL23^a, CCL16^b, CCL14^b	rs7221769 17:34,334,448	3.6×10^-93 replicable replicated
33	HCC-1 (cis) C-C motif chemokine 14	CCL15^ab, CCL15-CCL14^a, CCL23^a, CCL16^b, CCL14^b	rs7221769 17:34,334,448	6×10^-13
34 Top	MBL (cis) Mannose-binding protein C	MBL2^abc, DKK1^b	rs10824796 10:54,534,613	1×10^-89 replicable replicated		diagnosis
35 Top	SPINT2 (cis) Kunitz-type protease inhibitor 2	YIF1B^ac, C19orf33^ac, CATSPERG^ac, CTB-102L5.4^a, KCNK6^a [3 more]PSMD8^b, PPP1R14A^c, SPINT2^c	rs8112211 19:38,824,581	1×10^-88 replicable replicated		diagnosis
36 Top	DC-SIGN (trans) CD209 antigen	ABO^abc, TSC1^b, AK8^b, SARDH^b, GBGT1^c	rs505922 9:136,149,229	7.6×10^-86 replicable replicated
36	vWF (trans) von Willebrand factor	ABO^abc, TSC1^b, AK8^b, SARDH^b, GBGT1^c	rs612169 9:136,143,442	1.2×10^-20 replicable replicated		diagnosis, efficacy, prognosis
36	MBL (trans) Mannose-binding protein C	ABO^abc, TSC1^b, AK8^b, SARDH^b, GBGT1^c	rs687289 9:136,137,106	8.2×10^-10		diagnosis
37 Top	GPC5 (cis) Glypican-5	GPC5^a	rs342706 13:92,417,058	1.2×10^-83 replicable replicated
38 Top	TAFI (cis) Carboxypeptidase B2	CPB2^ace, ZC3H13^ac, LRRC63^b, LCP1^b	rs3742264 13:46,648,094	2.8×10^-83 replicable replicated
39 Top	SIG14 (cis) Sialic acid-binding Ig-like lectin 14	SIGLEC14^ac, SIGLEC5^ac, SIGLEC5^a	rs7250849 19:52,158,316	4.3×10^-82 replicable replicated
40 Top	KYNU (cis) Kynureninase	KYNU^ae	rs9013 2:143,798,189	1×10^-81 replicable replicated
41 Top	ILT-2 (cis) Leukocyte immunoglobulin-like receptor subfamily B member 1	LILRA1^abc, LILRB1^abe, LILRB4^ab, LILRA2^bc, LILRB2^bc [14 more]	rs2004318 19:55,138,232	1.8×10^-80 replicable replicated
42 Top	EphA1 (cis) Ephrin type-A receptor 1	EPHA1^ace, ZYX^ac	rs4725617 7:143,097,100	2.9×10^-80 replicable
43 Top	MP2K4 (trans) Dual specificity mitogen-activated protein kinase kinase 4	HRG^ae	rs1042445 3:186,395,436	8.4×10^-78 replicable replicated
43	CD27 (trans) CD27 antigen	HRG^ae	rs1042445 3:186,395,436	1.6×10^-28 replicable		unspecified application
43	ER (trans) Estrogen receptor	HRG^ae	rs1042445 3:186,395,436	6.2×10^-18	17-alpha-ethinylestradiol, fulvestrant, beta-estradiol, estradiol 17beta-cypionate, estriol, estrone, estradiol valerate, mestranol, CHF-4227, bazedoxifene, estradiol valerate/testosterone enanthate, TAS-108, ethinyl estradiol/ethynodiol diacetate, estradiol acetate, esterified estrogens, estradiol cypionate/medroxyprogesterone acetate, estradiol/norethindrone acetate, synthetic conjugated estrogens, A, estradiol cypionate/testosterone cypionate, B, etonogestrel, CC8490, MITO-4509, cyproterone acetate/ethinyl estradiol, ethinyl estradiol/etonogestrel, chlorotrianisene, megestrol acetate/tamoxifen, sulindac/tamoxifen, sulindac/toremifene, raloxifene/sulindac, ethynodiol, goserelin/tamoxifen, raloxifene/teriparatide, desogestrel/ethinyl estradiol, drospirenone/ethinyl estradiol, premarin, ethinyl estradiol/norelgestromin, ethinyl estradiol/norethindrone, ethinyl estradiol/levonorgestrel, ethinyl estradiol/norgestrel, ethinyl estradiol/norgestimate, conjugated estrogen/medroxyprogesterone acetate, diethylstilbestrol, ospemifene, toremifene, tamoxifen, raloxifene, arzoxifene, clomiphene, estramustine phosphate, diethylstilbestrol diphosphate, estropipate, dienestrol, estramustine, medroxyprogesterone acetate, desogestrel, danazol, trilostane, fluoxymesterone, norgestimate, progesterone	diagnosis, disease progression, efficacy, prognosis, response to therapy
44 Top	IL-1 R4 (cis) Interleukin-1 receptor-like 1	IL1RL1^abc, IL18R1^abc, MAP4K4^b, IL1R1^b, IL1R2^b [2 more]SLC9A4^c, IL18RAP^c	rs12712135 2:102,930,948	4.4×10^-76 replicable replicated
45 Top	Granulysin (cis)	VAMP8^bc, CAPG^b, IMMT^b, TMEM150A^b, TGOLN2^b [12 more]	rs12151621 2:85,934,499	5.8×10^-76 replicable replicated
46 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	TXNL4B^a, HPR^a, MARVELD3^c	rs217181 16:72,114,002	1.3×10^-75		diagnosis, efficacy, unspecified application
46	Ferritin (trans)	TXNL4B^a, HPR^a, MARVELD3^c	rs217181 16:72,114,002	4.1×10^-16
46	Heparin cofactor II (trans) Heparin cofactor 2	TXNL4B^a, HPR^a, MARVELD3^c	rs217181 16:72,114,002	3×10^-12	ardeparin, glucuronyl glucosamine glycan sulfate	disease progression
47 Top	Tenascin (cis)	TNC^ae	rs45602433 9:117,835,899	3.9×10^-74 replicable		diagnosis, response to therapy
48 Top	ILT-4 (cis) Leukocyte immunoglobulin-like receptor subfamily B member 2	LILRA1^bc, LILRB2^bc, LILRB3^b, LAIR1^b, KIR2DL3^b [13 more]	rs103294 19:54,797,848	1.7×10^-73 replicable replicated
49 Top	Siglec-9 (cis) Sialic acid-binding Ig-like lectin 9	CTU1^ac	rs2691273 19:51,596,136	3.1×10^-73 replicable replicated
50 Top	CPNE1 (cis) Copine-1	CPNE1^abce, RBM39^abc, SCAND1^abc, PHF20^abe, SPAG4^ab [9 more]	rs2425143 20:34,350,666	3.6×10^-73 replicable replicated
51 Top	Fucosyltransferase 3 (cis) Galactoside 3(4)-L-fucosyltransferase	FUT3^ae, FUT6^a	rs778986 19:5,844,537	8.8×10^-73 replicable replicated
52 Top	VEGF sR3 (trans) Vascular endothelial growth factor receptor 3	DCBLD2^c, CPOX^c, ST3GAL6^c	rs10935480 3:98,431,986	9.9×10^-70 replicable replicated	sunitinib, pazopanib, axitinib, CEP 7055, tivozanib, motesanib, telatinib, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, sorafenib, vandetanib	diagnosis, disease progression, efficacy, prognosis
53 Top	MCP-3 (cis) C-C motif chemokine 7	CCL8^ae	rs3138036 17:32,647,544	1.8×10^-69 replicable replicated
53	MCP-2 (cis) C-C motif chemokine 8	CCL8^ae	rs3138036 17:32,647,544	1.3×10^-14		unspecified application
54 Top	G-CSF (trans) Granulocyte colony-stimulating factor	APOC4^ae, APOC4-APOC2^ae, APOC2^a, CEACAM19^b, BCL3^b [3 more]APOE^c, CLPTM1^c, APOC1^c	rs5167 19:45,448,465	2.1×10^-69 replicable replicated	filgrastim	diagnosis
55 Top	IL-12 Rb1 (cis) Interleukin-12 receptor subunit beta-1	IL12RB1^ace	rs376008 19:18,189,568	6.3×10^-69 replicable replicated
56 Top	annexin II (cis) Annexin A2	ICE2^ac, ANXA2^a, RORA^a	rs36032232 15:60,776,991	6.9×10^-66 replicable replicated		diagnosis, unspecified application
57 Top	Semaphorin 3E (cis) Semaphorin-3E	SEMA3E^abe, CHI3L2^d	rs17284969 7:83,006,262	2.4×10^-65 replicable replicated
58 Top	Coagulation Factor VII (cis)	F10^ac, F7^c	rs776905 13:113,781,942	9.2×10^-65 replicable replicated	nematode anticoagulant protein c2	unspecified application
59 Top	RAP (trans) alpha-2-macroglobulin receptor-associated protein	HLA-B^abe, HLA-C^ab, MICB^ab, GTF2H4^b, HSPA1L^b [11 more]	rs1622406 6:31,308,862	7.1×10^-63
60 Top	Lysozyme (cis) Lysozyme C	LYZ^ac, YEATS4^c, CPM^c	rs7959452 12:69,735,492	1.2×10^-60 replicable replicated		unspecified application
61 Top	ENTP5 (cis) Ectonucleoside triphosphate diphosphohydrolase 5	ENTPD5^ac, CCDC176^ac, ALDH6A1^ac, LIN52^ac, RP5-1021I20.4^a [7 more]	rs17094448 14:74,440,119	1.2×10^-60 replicable replicated
62 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	CD38^c, BST1^c	rs12651314 4:15,753,570	3.7×10^-58 replicable replicated
63 Top	SLAF7 (cis) SLAM family member 7	SLAMF7^ac, LY9^bc, SLAMF1^b, B4GALT3^b, NCSTN^b [1 more]PVRL4^b	rs489286 1:160,722,550	1.5×10^-57 replicable replicated
64 Top	FCRL3 (cis) Fc receptor-like protein 3	FCRL3^ace, ATP1A4^c, FCRL1^c	rs7522061 1:157,668,390	5.4×10^-57 replicable replicated
65 Top	IL-17E (trans) Interleukin-25	OAF^abe, POU2F3^bc, ARHGEF12^b, TMEM136^b, TRIM29^b [1 more]PVRL1^b	rs692804 11:120,099,368	1.1×10^-56 replicable replicated
66 Top	TXD12 (trans) Thioredoxin domain-containing protein 12	CCDC36^a, USP4^a, MST1^c, ZNF589^c, APEH^c [2 more]NICN1^c, AMT^c	rs35395347 3:49,334,797	7.8×10^-55
67 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	DHX38^ac, TXNL4B^a, PMFBP1^a, HPR^c, DHODH^c [1 more]HP^c	rs9302635 16:72,144,174	6.3×10^-54 replicable replicated		diagnosis, efficacy, unspecified application
67	Ferritin (trans)	DHX38^ac, TXNL4B^a, PMFBP1^a, HPR^c, DHODH^c [1 more]HP^c	rs9302635 16:72,144,174	2.8×10^-10 replicated
68 Top	SPARCL1 (cis) SPARC-like protein 1	SPARCL1^abce, NUDT9^c, HSD17B11^c, HSD17B13^c, PPM1K^c	rs4693167 4:88,423,913	2.6×10^-53 replicable replicated		disease progression
69 Top	Cadherin-5 (trans)	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	6.1×10^-53 replicable replicated		diagnosis
69	sTie-1 (trans) Tyrosine-protein kinase receptor Tie-1, soluble	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	1.7×10^-51 replicable replicated
69	sTie-2 (trans) Angiopoietin-1 receptor, soluble	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	1.1×10^-35 replicable replicated	cabozantinib, regorafenib, ponatinib, cabozantinib/erlotinib, vandetanib	efficacy
69	Endoglin (cis)	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	5.6×10^-17		disease progression, efficacy
69	BCAM (trans) Basal Cell Adhesion Molecule	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	1.5×10^-11 replicated		diagnosis
69	CD109 (trans) CD109 antigen	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	1.7×10^-11
69	VEGF sR3 (trans) Vascular endothelial growth factor receptor 3	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	7.9×10^-11	sunitinib, pazopanib, axitinib, CEP 7055, tivozanib, motesanib, telatinib, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, sorafenib, vandetanib	diagnosis, disease progression, efficacy, prognosis
69	TCCR (trans) Interleukin-27 receptor subunit alpha	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	8.3×10^-11
69	Notch 1 (cis) Neurogenic locus notch homolog protein 1	ABO^abce, OBP2B^bc, DBH^b, SURF2^b, ADAMTSL2^b [12 more]	rs8176749 9:136,131,188	6×10^-10 replicated		diagnosis, efficacy
70 Top	CYTF (cis) Cystatin-F	CST7^ac, APMAP^ac, NINL^c	rs6138458 20:24,973,769	7.6×10^-53 replicable replicated
71 Top	GRN (trans) Granulins	PSRC1^ac, CELSR2^ac, AMPD2^b, SORT1^c	rs646776 1:109,818,530	1×10^-52 replicable replicated
71	Catalase (trans)	PSRC1^ac, CELSR2^ac, AMPD2^b, SORT1^c	rs646776 1:109,818,530	1.5×10^-11	fomepizole	diagnosis
71	RGMA (trans) Repulsive guidance molecule A	PSRC1^ac, CELSR2^ac, AMPD2^b, SORT1^c	rs646776 1:109,818,530	5.1×10^-10
72 Top	Hemopexin (trans)	CFHR4^ae, CFHR2^a, ASPM^a, ZBTB41^a	rs10494745 1:196,887,457	1.8×10^-52 replicable replicated
73 Top	Esterase D (cis) S-formylglutathione hydrolase	ESD^a	rs947409 13:47,377,928	2.2×10^-52 replicable replicated
74 Top	TLR4:MD-2 complex (cis) Toll-like receptor 4:Lymphocyte antigen 96 complex	TLR4^ace, BRINP1^c	rs4986791 9:120,475,602	1.8×10^-50 replicable replicated
75 Top	kallikrein 12 (cis) Kallikrein-12	KLK12^ac	rs8103941 19:51,546,852	5.3×10^-50 replicable replicated
76 Top	Hemopexin (trans)	CFHR4^ac, CFHR2^a, CFHR2^a, CFHR5^a, CFHR1^c [2 more]CFHR3^c, CFH^c	rs10801582 1:196,944,357	1.1×10^-49 replicable replicated
77 Top	Fibronectin (cis)	FN1^abce	rs1250258 2:216,300,185	1.3×10^-49 replicable replicated	ocriplasmin	diagnosis, efficacy, prognosis, unspecified application
77	FN1.3 (cis) Fibronectin Fragment 3	FN1^abce	rs1250258 2:216,300,185	1.8×10^-42 replicable replicated	ocriplasmin	diagnosis, efficacy, prognosis, unspecified application
77	FN1.4 (cis) Fibronectin Fragment 4	FN1^abce	rs1250258 2:216,300,185	1.2×10^-9 replicated	ocriplasmin	diagnosis, efficacy, prognosis, unspecified application
78 Top	KI2L4 (cis) Killer cell immunoglobulin-like receptor 2DL4	sentinel not in SNiPA's database	rs618835 19:55,316,329	2.3×10^-49
79 Top	CAMK1 (trans) Calcium/calmodulin-dependent protein kinase type 1	CPN1^a, HIF1AN^c	rs7091871 10:101,810,304	1×10^-48 replicable replicated
79	Calpastatin (trans)	CPN1^a, HIF1AN^c	rs7091871 10:101,810,304	1.4×10^-12 replicated
80 Top	IGF-II receptor (cis) Cation-independent mannose-6-phosphate receptor	IGF2R^a	rs600324 6:160,519,276	7.1×10^-48 replicable replicated
81 Top	Kallistatin (cis)	SERPINA5^ac, SERPINA4^a, SERPINA3^c, SERPINA3^c	rs882732 14:95,027,722	7.7×10^-48 replicable replicated
82 Top	Semaphorin 3A (trans) Semaphorin-3A	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	9.5×10^-48 replicable replicated
82	CAMK1D (trans) Calcium/calmodulin-dependent protein kinase type 1D	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	3×10^-24 replicable replicated
82	IL-5 (trans) Interleukin-5	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	4.8×10^-24 replicable		diagnosis, efficacy, response to therapy
82	WISP-1 (trans) WNT1-inducible-signaling pathway protein 1	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	1.1×10^-10 replicated
82	Cytidylate kinase (trans) UMP-CMP kinase	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	8×10^-10
82	Marapsin (trans) Serine protease 27	SARM1^ac, VTN^a, SLC46A1^a, TMEM199^c, POLDIP2^c [1 more]TMEM97^c	rs2239908 17:26,725,265	1.6×10^-9
83 Top	ASAHL (cis) N-acylethanolamine-hydrolyzing acid amidase	NAAA^abce, CXCL9^ac, ART3^ac, CXCL11^ac, SDAD1^a [7 more]	rs4859571 4:76,857,309	1.1×10^-46 replicable replicated
84 Top	Siglec-6 (cis) Sialic acid-binding Ig-like lectin 6	SIGLEC6^abce, SIGLEC12^c, ZNF175^c, SIGLEC5^c, SIGLEC5^c	rs2124910 19:52,025,247	2.7×10^-46 replicable replicated
85 Top	CD109 (cis) CD109 antigen	CD109^ac, EEF1A1^b	rs10455097 6:74,493,432	3.2×10^-46 replicable replicated
86 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	HP^ac, HPR^ac, DHX38^ac, TXNL4B^a, PMFBP1^a [1 more]DHODH^c	rs2000999 16:72,108,093	7.4×10^-45		diagnosis, efficacy, unspecified application
86	Heparin cofactor II (trans) Heparin cofactor 2	HP^ac, HPR^ac, DHX38^ac, TXNL4B^a, PMFBP1^a [1 more]DHODH^c	rs2000999 16:72,108,093	8.3×10^-17	ardeparin, glucuronyl glucosamine glycan sulfate	disease progression
86	Hemoglobin (trans)	HP^ac, HPR^ac, DHX38^ac, TXNL4B^a, PMFBP1^a [1 more]DHODH^c	rs2000999 16:72,108,093	5.3×10^-12
87 Top	PARC (cis) C-C motif chemokine 18	sentinel not in SNiPA's database	rs9904601 17:34,372,006	2.5×10^-43 replicable replicated		efficacy, safety
87	MIP-1a (cis) C-C motif chemokine 3	sentinel not in SNiPA's database	rs9904601 17:34,372,006	1.2×10^-17 replicable replicated		diagnosis, efficacy, prognosis
88 Top	HCC-1 (cis) C-C motif chemokine 14	CCL14^ab, CCL16^a, CCL15-CCL14^a, CCL15^a	rs41341749 17:34,310,702	3×10^-43 replicable replicated
88	MPIF-1 (cis) C-C motif chemokine 23	CCL14^ab, CCL16^a, CCL15-CCL14^a, CCL15^a	rs41341749 17:34,310,702	3.1×10^-32 replicable replicated
88	PARC (cis) C-C motif chemokine 18	CCL14^ab, CCL16^a, CCL15-CCL14^a, CCL15^a	rs41341749 17:34,310,702	6.3×10^-19		efficacy, safety
88	MIP-1a (cis) C-C motif chemokine 3	CCL14^ab, CCL16^a, CCL15-CCL14^a, CCL15^a	rs41341749 17:34,310,702	1×10^-9		diagnosis, efficacy, prognosis
89 Top	IL-17 RD (cis) Interleukin-17 receptor D	IL17RD^ae, FLNB^c, ARHGEF3^c	rs1463657 3:57,137,461	1.4×10^-42 replicable replicated
90 Top	CYTD (cis) Cystatin-D	CST5^ac, CST2^a, CSTL1^b, CST8^b, CST11^b [1 more]GGTLC1^b	rs6138152 20:23,850,130	1.8×10^-42 replicable replicated
91 Top	TXD12 (trans) Thioredoxin domain-containing protein 12	RBM6^ac, RNF123^ae, BSN^a, AMIGO3^a, GMPPB^a [18 more]	rs4688759 3:50,008,118	1.8×10^-42 replicable replicated
92 Top	HCC-1 (cis) C-C motif chemokine 14	CCL14^ae, CCL16^a, CCL15-CCL14^a, CCL15^a	rs16971802 17:34,311,387	9.6×10^-41 replicable replicated
93 Top	Collectin Kidney 1 (cis) Collectin-11	COLEC11^ac, ALLC^c	rs7588285 2:3,648,186	1.1×10^-40 replicable replicated
93	IL-19 (trans) Interleukin-19	COLEC11^ac, ALLC^c	rs7588285 2:3,648,186	2.7×10^-37 replicable replicated
93	IL-1b (trans) Interleukin-1 beta	COLEC11^ac, ALLC^c	rs7588285 2:3,648,186	2.5×10^-9	canakinumab, gevokizumab, canakinumab/INS, gallium nitrate	diagnosis, efficacy, prognosis
94 Top	WFKN2 (cis) WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2	TOB1^abc, WFIKKN2^ab, SPATA20^b, CACNA1G^b, NME2^b [7 more]	rs3803884 17:48,919,039	1.4×10^-40 replicable replicated
95 Top	TXD12 (trans) Thioredoxin domain-containing protein 12	IP6K2^abce, CELSR3^abc, NCKIPSD^abc, ARIH2^abc, WDR6^abc [29 more]	rs11715835 3:48,770,732	2.2×10^-40 replicable replicated
96 Top	Coagulation Factor XI (trans)	KNG1^ae	rs5030062 3:186,454,180	3×10^-40 replicable replicated
96	Prekallikrein (trans) Plasma kallikrein	KNG1^ae	rs5030062 3:186,454,180	1.8×10^-35 replicable replicated	aprotinin, ecallantide
97 Top	Cathepsin S (cis)	CTSS^ace, GOLPH3L^a, HORMAD1^a, CA14^b, CTSK^b [1 more]SEMA6C^c	rs41271951 1:150,737,220	4.1×10^-40
98 Top	C1s (trans) Complement C1s subcomponent	CFH^a, CFHR3^c	rs6695321 1:196,675,861	9.4×10^-40 replicable replicated	SERPING1
98	complement factor H-related 5 (cis) Complement factor H-related protein 5	CFH^a, CFHR3^c	rs6695321 1:196,675,861	2.7×10^-20 replicable
99 Top	Gro-a (cis) Growth-regulated alpha protein	CXCL1^a, ALB^b, AFP^b, PF4^c, CXCL6^c	rs16845091 4:74,758,801	1.6×10^-39 replicable replicated		disease progression
100 Top	a2-HS-Glycoprotein (cis) Alpha-2-HS-glycoprotein	AHSG^a	rs2518136 3:186,337,827	1.7×10^-39 replicable replicated		unspecified application
101 Top	TIMD3 (cis) Hepatitis A virus cellular receptor 2	HAVCR2^abce, ADAM19^b, HAVCR1^c, MED7^c	rs4704846 5:156,513,344	1.8×10^-39 replicable replicated		unspecified application
102 Top	CNTN2 (cis) Contactin-2	CNTN2^abc, RBBP5^abc, DSTYK^abc, TMEM81^ace, TMCC2^a	rs4951168 1:205,053,219	2.1×10^-39 replicable replicated
103 Top	bFGF (cis) Fibroblast growth factor 2	FGF2^ac	rs308403 4:123,757,748	5.8×10^-39 replicable replicated	pentosan polysulfate, suradista, sucralfate	diagnosis, efficacy, prognosis
104 Top	Angiogenin (cis)	RNASE4^abc, ANG^abc, RP11-903H12.5^ac	rs17114671 14:21,155,270	1.9×10^-38 replicable replicated		response to therapy
105 Top	MICB (cis) MHC class I polypeptide-related sequence B	HLA-B^abc, MICB^abc, DDX39B^abc, HLA-C^ac, MICA^ac [58 more]	rs3094005 6:31,465,047	4.2×10^-38 replicable replicated		safety
106 Top	Protein C (trans) Vitamin K-dependent protein C	TRPC4AP^abc, EDEM2^abc, PROCR^ace, GSS^ab, MYH7B^ab [18 more]	rs867186 20:33,764,554	5.4×10^-38 replicable replicated		diagnosis, efficacy
107 Top	MMP-12 (cis) Macrophage metalloelastase	MMP3^ab, MMP12^a, DYNC2H1^b, MMP20^b	rs17368582 11:102,738,075	1.5×10^-37 replicable replicated	marimastat	efficacy, unspecified application
108 Top	IMDH1 (trans) Inosine-5'-monophosphate dehydrogenase 1	ANKRD9^abc, TECPR2^ac, CINP^c, ZNF839^c	rs1190552 14:102,911,907	1.5×10^-37 replicable	thioguanine, VX-944, pegintron/ribavirin, PEG-interferon alfa-2a/ribavirin, nitazoxanide/peginterferon alfa-2a/ribavirin, interferon alfa-2b/ribavirin, mycophenolate mofetil, mycophenolic acid, ribavirin
109 Top	Carbonic anhydrase 6 (cis)	CA6^a	rs6697763 1:9,037,273	3×10^-37 replicable replicated	methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, chlorothiazide, chlorthalidone, benzthiazide, sulfacetamide, topiramate
110 Top	CYTN (cis) Cystatin-SN	CST1^ace, CST9L^b, CSTL1^b, CST8^b, CST11^b [1 more]GGTLC1^b	rs6114248 20:23,711,882	5×10^-37 replicable replicated
110	CYTT (cis) Cystatin-SA	CST1^ace, CST9L^b, CSTL1^b, CST8^b, CST11^b [1 more]GGTLC1^b	rs6114248 20:23,711,882	4.4×10^-31 replicable replicated
111 Top	Factor H (cis) Complement factor H	CFH^ac, CFHR1^c, CFHR3^c	rs10737680 1:196,679,455	1.3×10^-36 replicable replicated		unspecified application
112 Top	Hemopexin (trans)	CFH^a	rs419137 1:196,696,875	4.2×10^-36
113 Top	Mn SOD (trans) Superoxide dismutase [Mn], mitochondrial	F12^abc, GRK6^a, RGS14^c, RAB24^c, MXD3^c [1 more]GRIN2B^d	rs2545801 5:176,841,339	4.6×10^-36		diagnosis, unspecified application
114 Top	HGFA (cis) Hepatocyte growth factor activator	RGS12^a	rs1203119 4:3,406,952	1.1×10^-35
115 Top	C1r (cis) Complement C1r subcomponent	C1S^abce, C1RL^c	rs12146727 12:7,170,336	3.4×10^-35 replicable replicated	SERPING1
115	C1q (trans) Complement C1q subcomponent	C1S^abce, C1RL^c	rs12146727 12:7,170,336	2×10^-15 replicated
116 Top	ASAH2 (cis) Neutral ceramidase	FAM21A^c	rs2842126 10:52,018,482	5.7×10^-34 replicable replicated
117 Top	TAFI (cis) Carboxypeptidase B2	LCP1^bc, ZC3H13^a, CPB2^a, LRRC63^b	rs9534288 13:46,605,441	1.1×10^-33 replicable replicated
118 Top	DAF (cis) Complement decay-accelerating factor	CD55^ac, IL20^b, PIGR^b, C4BPB^b, CR1^c	rs12134133 1:207,457,845	1.6×10^-33 replicable replicated
119 Top	MP2K2 (trans) Dual specificity mitogen-activated protein kinase kinase 2	PROZ^abc, PCID2^abc, CUL4A^abc, ADPRHL1^b, TMCO3^b [9 more]	rs556990 13:113,845,059	2.2×10^-33 replicable	selumetinib, trametinib, dabrafenib/trametinib
120 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	CAST^ac, ERAP1^c	rs149313 5:96,070,205	4.2×10^-33 replicable replicated
121 Top	SAA (cis) Serum amyloid A-1 protein	HPS5^abc, GTF2H1^abc, LDHA^bc, TSG101^b, UEVLD^b [2 more]SAA1^c, LDHC^c	rs4150579 11:18,357,180	5.5×10^-33 replicable replicated		diagnosis, unspecified application
122 Top	DLRB1 (trans) Dynein light chain roadblock-type 1	TRIM58^ae	rs1339847 1:248,039,294	9.2×10^-33 replicable replicated
123 Top	MMP-8 (trans) Neutrophil collagenase	SKIV2L^ac, C2^a, XXbac-BPG116M5.17^a, NELFE^a, DXO^a [1 more]STK19^a	rs9283893 6:31,897,219	1.2×10^-32 replicable replicated	marimastat	efficacy
124 Top	Siglec-9 (cis) Sialic acid-binding Ig-like lectin 9	SIGLEC9^a	rs1568003 19:51,633,660	4.4×10^-32
125 Top	ILT-2 (cis) Leukocyte immunoglobulin-like receptor subfamily B member 1	LILRB1^abce, LILRA1^a, TMC4^b, TTYH1^b, TSEN34^b [7 more]	rs45461791 19:55,112,396	5.5×10^-32 replicable
126 Top	GPVI (cis) Platelet glycoprotein VI	RDH13^ac, GP6^ac, NLRP2^c	rs1654439 19:55,553,647	6.6×10^-31 replicable replicated
127 Top	IGF-II receptor (cis) Cation-independent mannose-6-phosphate receptor	IGF2R^ac, LPA^b	rs2297363 6:160,506,462	8.2×10^-31 replicable replicated
128 Top	SREC-I (cis) Scavenger receptor class F member 1	PRPF8^a	rs8071756 17:1,574,342	9.4×10^-31 replicable
129 Top	MMP-1 (cis) Interstitial collagenase	MMP1^ac, MMP27^b, MMP3^b, DYNC2H1^b	rs484915 11:102,673,248	2.1×10^-30 replicable replicated	marimastat	diagnosis, efficacy, safety
130 Top	MSP (cis) Hepatocyte growth factor-like protein	IP6K2^abce, SLC26A6^abce, NCKIPSD^abc, CELSR3^ace, TMEM89^ac [25 more]	rs13063312 3:48,661,985	4.4×10^-30 replicable replicated
131 Top	Angiogenin (cis)	RP11-903H12.5^a, RNASE4^a, ANG^a, RNASE9^c	rs17114699 14:21,158,910	7.3×10^-30		response to therapy
132 Top	MMP-8 (trans) Neutrophil collagenase		rs2736186 6:31,572,333	1.1×10^-29	marimastat	efficacy
133 Top	Lysozyme (cis) Lysozyme C	LYZ^abe	rs1800973 12:69,744,014	2.4×10^-29		unspecified application
134 Top	NAGK (cis) N-acetyl-D-glucosamine kinase	NAGK^abc, MPHOSPH10^b, ZNF638^b, CD207^b, MCEE^c	rs6714900 2:71,325,355	3.8×10^-29 replicable
135 Top	BGH3 (cis) Transforming growth factor-beta-induced protein ig-h3	TGFBI^abc, SMAD5^c, TRPC7^c	rs3792900 5:135,393,754	4.2×10^-29 replicable replicated
136 Top	Siglec-6 (cis) Sialic acid-binding Ig-like lectin 6	SIGLEC6^abe, SIGLEC12^b, SIGLEC14^b, SIGLEC10^b, ZNF175^c [1 more]LRRC4B^c	rs2005199 19:52,033,206	5.1×10^-29 replicable replicated
137 Top	C4b (cis) Complement C4b	CYP21A2^ace, NELFE^ac, DXO^ac, TNXB^ae, C2^a [28 more]	rs2280774 6:31,928,691	7.6×10^-29 replicable replicated
137	C34 gp41 HIV Fragment (trans) gp41 C34 peptide, HIV	CYP21A2^ace, NELFE^ac, DXO^ac, TNXB^ae, C2^a [28 more]	rs2280774 6:31,928,691	8.5×10^-12
138 Top	Prekallikrein (cis) Plasma kallikrein	KLKB1^ab, F11^c, CYP4V2^c	rs1511802 4:187,150,806	9.1×10^-29 replicable replicated	aprotinin, ecallantide
139 Top	MIA (cis) Melanoma-derived growth regulatory protein	C19orf54^abc, MIA^ac, ADCK4^a, ITPKC^a, SNRPA^a [3 more]	rs1455434 19:41,257,046	1.7×10^-28 replicable replicated		disease progression, prognosis
140 Top	PDK1 (cis) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	PDK1^abc, ITGA6^a, METAP1D^b	rs12052479 2:173,404,804	2.5×10^-28 replicable	dichloroacetic acid
141 Top	FCG3B (cis) Low affinity immunoglobulin gamma Fc region receptor III-B	HSPA6^ab, FCGR3A^a, USF1^b, UFC1^b, TOMM40L^b [2 more]FCRLB^c, FCGR2B^c	rs10919544 1:161,508,763	3.5×10^-28 replicable replicated	IgG
141	FCG2A/B (cis) Low affinity immunoglobulin gamma Fc region receptor II-a/b	HSPA6^ab, FCGR3A^a, USF1^b, UFC1^b, TOMM40L^b [2 more]FCRLB^c, FCGR2B^c	rs10919544 1:161,508,763	6.4×10^-21 replicable
142 Top	Factor B (cis) Complement factor B	DXO^ac, C2^ae, CFB^ae, EHMT2^a, SLC44A4^a [9 more]	rs4151669 6:31,915,144	6.3×10^-28
143 Top	IL-5 Ra (cis) Interleukin-5 receptor subunit alpha	IL5RA^ae	rs2290610 3:3,139,957	7.6×10^-28 replicable replicated
144 Top	sFRP-3 (cis) Secreted frizzled-related protein 3	FRZB^ae	rs288326 2:183,703,336	8.6×10^-28 replicable replicated
145 Top	Cathepsin B (cis)	FDFT1^abc, CTSB^abc, FAM167A^bc, BLK^b, DEFB130^b [2 more]DEFB130^b, ANTXR1^d	rs3947 8:11,702,375	1.5×10^-27 replicable
146 Top	MICB (cis) MHC class I polypeptide-related sequence B	MICB^abc, LST1^abc, DDX39B^ab, ATP6V1G2^ab, TNF^ab [36 more]	rs2905736 6:31,453,290	1.8×10^-27		safety
147 Top	TPSB2 (cis) Tryptase beta-2	TPSD1^abc, TPSG1^ac, TPSB2^ac, TPSAB1^ac, CACNA1H^a [1 more]CHTF18^b	rs4984778 16:1,297,516	2.7×10^-27 replicable replicated
148 Top	PLXC1 (cis) Plexin-C1	PLXNC1^a	rs2361355 12:94,630,029	8.6×10^-27 replicable replicated
149 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICA^abc, VARS2^b, PSORS1C2^c, CCHCR1^c, HLA-B^c [1 more]PSORS1C1^c	rs17206736 6:31,389,768	1.3×10^-26		safety
150 Top	b-Endorphin (trans) Beta-endorphin	SIK3^ab, SIDT2^bc, PCSK7^b, BUD13^b, RNF214^b [2 more]CEP164^b, APOA1^c	rs12099358 11:116,726,048	1.6×10^-26 replicable replicated		diagnosis, efficacy, unspecified application
151 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	BST1^abce, FBXL5^ab, CC2D2A^a, FAM200B^a	rs7657257 4:15,646,941	1.6×10^-26 replicable replicated
152 Top	PD-L2 (cis) Programmed cell death 1 ligand 2	PDCD1LG2^ac, KIAA2026^b	rs16923189 9:5,510,644	1.6×10^-26 replicable replicated
153 Top	Semaphorin 3E (cis) Semaphorin-3E	SEMA3E^ac	rs536299 7:83,267,983	2.2×10^-26 replicable replicated
154 Top	PDGF Rb (cis) Platelet-derived growth factor receptor beta	PDGFRB^ac, CSF1R^c	rs3756309 5:149,505,624	2.5×10^-26 replicable replicated	nilotinib, dasatinib, sunitinib, pazopanib, axitinib, tivozanib, tandutinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, imatinib, sorafenib, becaplermin	prognosis, response to therapy, unspecified application
155 Top	MP2K2 (trans) Dual specificity mitogen-activated protein kinase kinase 2	PROZ^ac, PCID2^a, CUL4A^a	rs515863 13:113,839,747	2.5×10^-26 replicable replicated	selumetinib, trametinib, dabrafenib/trametinib
156 Top	PPID (cis) Peptidyl-prolyl cis-trans isomerase D	PPID^ace, ETFDH^ac	rs8396 4:159,630,817	3.4×10^-26 replicable
157 Top	Alkaline phosphatase, bone (trans) Alkaline phosphatase, tissue-nonspecific isozyme	LTF^abe, CCR5^b, CCR3^c	rs1126478 3:46,501,213	5.1×10^-26 replicable replicated		efficacy, safety
158 Top	P-Selectin (cis)	F5^ac, SELP^ae	rs6136 1:169,563,951	1.1×10^-25		efficacy, safety, unspecified application
159 Top	C34 gp41 HIV Fragment (trans) gp41 C34 peptide, HIV	SKIV2L^ace, C4B^ac, TNXB^ab, DXO^a, STK19^a [20 more]	rs387608 6:31,941,557	2.5×10^-25 replicable replicated
160 Top	HRG (cis) Histidine-rich glycoprotein	FETUB^a, HRG^a	rs2555515 3:186,388,028	2.8×10^-25 replicable
161 Top	Catalase (cis)	CAT^ac, ELF5^a, NAT10^b, CAPRIN1^b, ABTB2^c	rs2284367 11:34,484,542	4.1×10^-25 replicable	fomepizole	diagnosis
162 Top	CDON (cis) Cell adhesion molecule-related/down-regulated by oncogenes	CDON^ae	rs3740909 11:125,889,526	4.4×10^-25 replicable replicated
163 Top	sL-Selectin (cis) L-Selectin	C1orf112^ac, SELL^ac	rs12938 1:169,660,781	4.5×10^-25 replicable replicated		efficacy
164 Top	Coagulation Factor XI (cis)	F11^a, IRF2^c	rs2289252 4:187,207,381	4.6×10^-25 replicable replicated
165 Top	Coagulation Factor V (cis)	F5^ae	rs6033 1:169,521,853	5.5×10^-25 replicable replicated	drotrecogin alfa, antithrombin alfa	diagnosis
166 Top	Semaphorin 3E (cis) Semaphorin-3E		rs3109167 7:82,977,124	9.1×10^-25 replicable
167 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICA^abc, HLA-B^bc, LY6G5C^bc, LTB^b, CSNK2B^b [14 more]	rs9469012 6:31,421,300	9.6×10^-25 replicable replicated		safety
168 Top	IL-18 Rb (cis) Interleukin-18 receptor accessory protein	IL18R1^ac, IL18RAP^ac, SLC9A4^ab, IL1R2^b, SLC9A2^b [1 more]IL1RL1^c	rs6543140 2:103,074,274	1×10^-24 replicable
169 Top	Chitotriosidase-1 (cis)	CHIT1^ae	rs4950937 1:203,182,292	1.4×10^-24 replicable replicated		efficacy
170 Top	MICA (cis) MHC class I polypeptide-related sequence A	HLA-C^ac, MICA^ac, HLA-B^a, SLC44A4^b, CCHCR1^b [8 more]	rs2524280 6:31,416,990	2.6×10^-24 replicable		safety
171 Top	PPIE (cis) Peptidyl-prolyl cis-trans isomerase E	PPIE^abc, BMP8B^ac, MACF1^b, OXCT2^c	rs9787249 1:40,212,878	8.9×10^-24 replicable
172 Top	Coagulation Factor V (cis)	F5^ae	rs9332701 1:169,484,767	1.2×10^-23	drotrecogin alfa, antithrombin alfa	diagnosis
173 Top	Hemopexin (trans)	CRB1^a	rs2786107 1:197,310,777	1.4×10^-23 replicable
174 Top	NKp30 (cis) Natural cytotoxicity triggering receptor 3	LST1^abc, NCR3^abc, ATP6V1G2^ac, TNF^ab, AIF1^bc [20 more]	rs6916921 6:31,520,426	2.2×10^-23 replicable replicated
175 Top	MICA (cis) MHC class I polypeptide-related sequence A	ATP6V1G2^c, HCG27^c, LST1^c, LY6G5C^c, C4A^c [5 more]	rs2516470 6:31,407,331	4.5×10^-23		safety
176 Top	SLAF7 (cis) SLAM family member 7	ITLN1^ab, CD244^a, USF1^b, SLAMF7^b, TOMM40L^b [7 more]	rs11578770 1:160,845,636	7.5×10^-23
177 Top	Properdin (trans)	CFH^ace, CFHR1^c, CFHR3^c	rs7529589 1:196,658,279	2.4×10^-22 replicable
178 Top	IGFBP-3 (cis) Insulin-like growth factor-binding protein 3	IGFBP3^c	rs2949833 7:45,984,820	2.6×10^-22 replicable replicated		diagnosis, disease progression, efficacy, prognosis, safety
178	IGF-I (trans) Insulin-like growth factor I	IGFBP3^c	rs2949833 7:45,984,820	3×10^-12		diagnosis, efficacy, prognosis, safety
179 Top	MICA (cis) MHC class I polypeptide-related sequence A	HLA-B^abc, HLA-C^ab, CSNK2B^b, DDX39B^b, VARS^b [12 more]	rs2523570 6:31,329,734	2.7×10^-22 replicable		safety
180 Top	MICB (cis) MHC class I polypeptide-related sequence B	RNF39^abc, TRIM31^abc, FLOT1^abc, PPP1R18^ace, ZNRD1^ac [38 more]	rs3132645 6:30,409,249	3.9×10^-22 replicable		safety
181 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	IST1^a, PKD1L3^a, AP1G1^c, PHLPP2^c, HP^c	rs17286411 16:71,968,701	4.9×10^-22 replicable replicated		diagnosis, efficacy, unspecified application
182 Top	RAP (trans) alpha-2-macroglobulin receptor-associated protein	TAP2^a, PSMB9^a, XXbac-BPG246D15.9^a, TAP1^a, PSMB8^a [3 more]HLA-DOB^b, COL11A2^b, HLA-DPB1^b	rs17220241 6:32,822,244	9.6×10^-22 replicable replicated
183 Top	IL-7 Ra (cis) Interleukin-7 receptor subunit alpha	IL7R^a	rs11957503 5:35,883,176	1.9×10^-21 replicable replicated	recombinant human interleukin-7
184 Top	TSG-6 (cis) Tumor necrosis factor-inducible gene 6 protein	RBM43^ac, NMI^ac, RIF1^c, TNFAIP6^c	rs289828 2:152,137,181	2.1×10^-21 replicable replicated		unspecified application
185 Top	sTie-2 (cis) Angiopoietin-1 receptor, soluble	TEK^abe	rs35030851 9:27,197,486	4.1×10^-21 replicable replicated	cabozantinib, regorafenib, ponatinib, cabozantinib/erlotinib, vandetanib	efficacy
186 Top	VEGF sR2 (cis) Vascular endothelial growth factor receptor 2	KDR^ae	rs34231037 4:55,972,946	4.5×10^-21	AEE 788, sunitinib, cediranib, pazopanib, axitinib, XL647, CEP 7055, brivanib alaninate, CHIR-265, tivozanib, motesanib, OSI-930, telatinib, ramucirumab, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, docetaxel/ramucirumab, vatalanib, sorafenib, vandetanib, pegaptanib	disease progression, efficacy, prognosis, response to therapy, safety
187 Top	IP-10 (cis) C-X-C motif chemokine 10	CXCL10^ae, ART3^a	rs11548618 4:76,943,947	4.9×10^-21	MDX-1100	diagnosis, efficacy, unspecified application
188 Top	CLM6 (trans) CMRF35-like molecule 6	POC1B^ac, POC1B-GALNT4^ac, GALNT4^ac, ATP2B1^c	rs10858881 12:89,891,474	5.1×10^-21 replicable
189 Top	TECK (cis) C-C motif chemokine 25	FBN3^ae, ELAVL1^a	rs3848570 19:8,145,928	7.6×10^-21		disease progression
190 Top	Fucosyltransferase 3 (cis) Galactoside 3(4)-L-fucosyltransferase	FUT3^ae	rs28362459 19:5,844,792	1.1×10^-20 replicated
191 Top	ATS13 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 13	SURF2^abc, SURF1^abc, REXO4^abc, SURF6^ac, MED22^ac [8 more]	rs3118663 9:136,281,753	1.4×10^-20 replicable replicated
192 Top	HAI-1 (trans) Kunitz-type protease inhibitor 1	RP5-864K19.6^ace, GJA9^ace, RHBDL2^ace, RRAGC^ab, MYCBP^ac [1 more]MACF1^b	rs4494114 1:39,339,682	1.9×10^-20 replicated
193 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a, TIMP3^a	rs241890 22:33,242,162	2.6×10^-20 replicable replicated		diagnosis, prognosis, unspecified application
194 Top	MBL (cis) Mannose-binding protein C	sentinel not in SNiPA's database	rs5784945 10:54,544,242	4.2×10^-20 replicable replicated		diagnosis
195 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	FBXL5^abc, CC2D2A^ac, FAM200B^a, BST1^b, C1QTNF7^c	rs1789 4:15,664,535	4.5×10^-20 replicable replicated
196 Top	LY9 (cis) T-lymphocyte surface antigen Ly-9	LY9^ac, SLAMF7^c	rs540254 1:160,767,737	7.8×10^-20
197 Top	Carbonic anhydrase XIII (cis) Carbonic anhydrase 13	E2F5^abe, CA1^ab, CA3^ab, C8orf59^a, CA13^a [1 more]LRRCC1^c	rs17741049 8:86,198,253	7.9×10^-20	methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, chlorothiazide, chlorthalidone, benzthiazide, sulfacetamide, topiramate
198 Top	MICB (cis) MHC class I polypeptide-related sequence B	LY6G6D^b, SLC44A4^b, LY6G6E^b, CCHCR1^b, ATP6V1G2^c [9 more]	rs2248372 6:31,446,466	9.7×10^-20 replicable replicated		safety
199 Top	MICB (cis) MHC class I polypeptide-related sequence B	GABBR1^abc, OR12D3^abe, TRIM27^ab, OR2B3^ab, ZNF311^a [30 more]	rs3129682 6:29,283,672	1.3×10^-19 replicable		safety
199	MICA (cis) MHC class I polypeptide-related sequence A	GABBR1^abc, OR12D3^abe, TRIM27^ab, OR2B3^ab, ZNF311^a [30 more]	rs3131085 6:29,044,701	9.7×10^-10		safety
200 Top	Factor B (cis) Complement factor B	SKIV2L^abce, CFB^ab, NELFE^ac, C2^a, XXbac-BPG116M5.17^a [2 more]PRRT1^c, NEU1^c	rs550513 6:31,920,687	1.3×10^-19 replicated
201 Top	Cathepsin S (cis)	CTSS^abce, CTSK^abc, ARNT^abc, HORMAD1^ace, GOLPH3L^ac [11 more]	rs1336900 1:150,679,033	1.4×10^-19 replicable replicated
202 Top	Ck-b-8-1 (cis) Ck-beta-8-1	CCL23^ace, CCL15-CCL14^ac, CCL15^a, CCL14^c	rs1003645 17:34,340,284	1.6×10^-19 replicated
203 Top	Endothelin-converting enzyme 1 (trans)	PCOLCE2^ac, U2SURP^b, ATR^b, PLS1^b	rs4683702 3:142,617,138	2×10^-19 replicable replicated
204 Top	GFRa-2 (cis) GDNF family receptor alpha-2	GFRA2^ac	rs4443656 8:21,541,084	2.2×10^-19 replicable replicated
205 Top	MICA (cis) MHC class I polypeptide-related sequence A	CLIC1^a, MSH5-SAPCD1^a, MSH5^a, SAPCD1^a, VARS^a [13 more]	rs3828922 6:31,713,454	2.3×10^-19		safety
205	C34 gp41 HIV Fragment (trans) gp41 C34 peptide, HIV	CLIC1^a, MSH5-SAPCD1^a, MSH5^a, SAPCD1^a, VARS^a [13 more]	rs2075801 6:31,728,267	7.9×10^-15
205	C4 (cis) Complement C4	CLIC1^a, MSH5-SAPCD1^a, MSH5^a, SAPCD1^a, VARS^a [13 more]	rs409558 6:31,708,147	1.2×10^-10
206 Top	MICB (cis) MHC class I polypeptide-related sequence B	BTNL2^ab, XXbac-BPG246D15.9^ac, C6orf10^a, HLA-DRA^a, HLA-DOB^a [22 more]	rs1794282 6:32,666,526	2.6×10^-19 replicable		safety
207 Top	RET (cis) Proto-oncogene tyrosine-protein kinase receptor Ret	RET^abc, HNRNPF^b, BMS1^b, RASGEF1A^b, ZNF239^b [2 more]CSGALNACT2^c, ZNF33B^c	rs2505535 10:43,593,043	2.8×10^-19 replicated	sunitinib, motesanib, cabozantinib, regorafenib, ponatinib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, cabozantinib/erlotinib, imatinib/nilotinib/pegintron, imatinib, sorafenib, vandetanib	efficacy, response to therapy
208 Top	SIRT2 (trans) NAD-dependent protein deacetylase sirtuin-2	APOH^ae, PRKCA^a	rs1801689 17:64,210,580	2.8×10^-19
208	Dkk-4 (trans) Dickkopf-related protein 4	APOH^ae, PRKCA^a	rs1801689 17:64,210,580	7×10^-10
209 Top	PPAC (cis) Low molecular weight phosphotyrosine protein phosphatase	SH3YL1^ac, FAM150B^a, ACP1^a	rs300756 2:233,416	3×10^-19 replicable replicated
210 Top	NXPH1 (trans) Neurexophilin-1	C1orf168^bc, C8A^a, C8B^a, DAB1^b	rs626457 1:57,407,484	3.3×10^-19 replicable replicated
210	I-309 (trans) C-C motif chemokine 1	C1orf168^bc, C8A^a, C8B^a, DAB1^b	rs626457 1:57,407,484	2.7×10^-9
211 Top	CYTN (cis) Cystatin-SN	CST1^ace	rs2070856 20:23,731,412	5.6×10^-19
212 Top	SIRT2 (trans) NAD-dependent protein deacetylase sirtuin-2	APOH^ae, CEP112^a	rs8178847 17:64,216,815	8.2×10^-19 replicable
212	Dkk-4 (trans) Dickkopf-related protein 4	APOH^ae, CEP112^a	rs8178847 17:64,216,815	4.1×10^-17 replicable
213 Top	TSP2 (cis) Thrombospondin-2	THBS2^b, WDR27^b	rs3763267 6:169,571,693	8.6×10^-19
214 Top	Spondin-1 (cis)	SPON1^abc, COPB1^b, RRAS2^b	rs10832169 11:14,066,486	8.7×10^-19 replicated
215 Top	Calpain I (cis)	SYVN1^ab, SPDYC^ac, VPS51^a, TM7SF2^a, MRPL49^a [6 more]	rs10895987 11:64,904,908	1×10^-18
216 Top	HCC-1 (cis) C-C motif chemokine 14	RDM1^a, LYZL6^a	rs17676662 17:34,262,254	1.2×10^-18
217 Top	EDAR (cis) Tumor necrosis factor receptor superfamily member EDAR	EDAR^ab, LIMS1^b, SULT1C3^c	rs6750059 2:109,611,097	1.3×10^-18 replicable
218 Top	PPase (cis) Inorganic pyrophosphatase	PPA1^ac, NPFFR1^a, SAR1A^c, AIFM2^c, EIF4EBP2^c [1 more]TYSND1^c	rs10823500 10:72,005,190	1.5×10^-18
219 Top	SIG14 (cis) Sialic acid-binding Ig-like lectin 14	SIGLEC5^a, SIGLEC5^a, SIGLEC14^c	rs6509558 19:52,127,949	2.2×10^-18
220 Top	Contactin-5 (cis)	CNTN5^a	rs1461672 11:99,175,378	2.2×10^-18 replicable
221 Top	Siglec-3 (cis) Myeloid cell surface antigen CD33	ETFB^c, CD33^c	rs1710354 19:51,802,140	2.3×10^-18 replicable	arsenic trioxide/gemtuzumab ozogamicin/tretinoin, gemtuzumab ozogamicin	efficacy
222 Top	MIA (cis) Melanoma-derived growth regulatory protein	CTC-490E21.12^a, CYP2A6^a, CYP2A7^a	rs4803378 19:41,333,441	2.5×10^-18		disease progression, prognosis
223 Top	Siglec-3 (cis) Myeloid cell surface antigen CD33		rs10421385 19:51,701,891	2.9×10^-18	arsenic trioxide/gemtuzumab ozogamicin/tretinoin, gemtuzumab ozogamicin	efficacy
224 Top	DAPK2 (cis) Death-associated protein kinase 2	DAPK2^ac	rs922182 15:64,277,642	3.1×10^-18 replicable
225 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a	rs135150 22:33,170,101	4.4×10^-18		diagnosis, prognosis, unspecified application
226 Top	ENTP5 (cis) Ectonucleoside triphosphate diphosphohydrolase 5	ALDH6A1^ac, LIN52^ac, CCDC176^ae, ENTPD5^a, COQ6^c [1 more]PTGR2^c	rs7160336 14:74,572,360	6×10^-18 replicated
227 Top	ART (cis) Agouti-related protein	ZDHHC1^abc, HSD11B2^abc, ATP6V0D1^abc, LRRC36^ace, AGRP^ace [25 more]	rs7184253 16:67,380,550	6.7×10^-18 replicable		unspecified application
228 Top	IL-1 R4 (cis) Interleukin-1 receptor-like 1	IL18RAP^a, IL18R1^b	rs12997015 2:103,042,401	7.7×10^-18
229 Top	C7 (cis) Complement component C7	PLCXD3^bc, C6^a, C7^c	rs429017 5:41,263,091	9×10^-18
230 Top	Factor I (cis) Complement factor I	PLA2G12A^ac, CFI^ab, CASP6^c	rs7439493 4:110,656,730	1.6×10^-17
231 Top	IL-1 R AcP (cis) Interleukin-1 Receptor accessory protein	IL1RAP^a	rs2193873 3:190,313,507	1.7×10^-17
232 Top	ASM3A (cis) Acid sphingomyelinase-like phosphodiesterase 3a	SMPDL3A^abce	rs28385609 6:123,122,464	1.7×10^-17
233 Top	SAA (cis) Serum amyloid A-1 protein	LDHC^ab, LDHAL6A^ac, TSG101^b, SERGEF^b, UEVLD^b [3 more]LDHA^b, GTF2H1^b, SPTY2D1^b	rs16935432 11:18,470,487	1.9×10^-17 replicable replicated		diagnosis, unspecified application
234 Top	EDAR (cis) Tumor necrosis factor receptor superfamily member EDAR	EDAR^a	rs260692 2:109,581,319	2.1×10^-17
235 Top	C4 (cis) Complement C4	ATF6B^ac, TNXB^a, TAP2^c, XXbac-BPG246D15.9^c, FKBPL^c [1 more]MICB^c	rs8283 6:32,083,300	2.3×10^-17 replicated
236 Top	MICA (cis) MHC class I polypeptide-related sequence A		rs1265047 6:31,081,464	2.4×10^-17		safety
237 Top	IMDH2 (trans) Inosine-5'-monophosphate dehydrogenase 2	ZNF839^ac, CINP^ac, TECPR2^ac, ANKRD9^c	rs1005776 14:102,896,673	3.2×10^-17	thioguanine, VX-944, pegintron/ribavirin, interferon alfa-2b/ribavirin, mycophenolate mofetil, mycophenolic acid, ribavirin
238 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	LIX1^b, ERAP2^c, CAST^c, LNPEP^c	rs12520053 5:96,167,485	3.6×10^-17
239 Top	IGFBP-7 (cis) Insulin-like growth factor-binding protein 7	IGFBP7^a, POLR2B^b	rs2412776 4:57,951,468	5.5×10^-17
240 Top	FCG2A/B (cis) Low affinity immunoglobulin gamma Fc region receptor II-a/b	FCGR2B^ac, FCRLA^ac, FCGR3B^c, FCRLB^c, HSPA6^c	rs6668534 1:161,671,995	6×10^-17
241 Top	FCN1 (cis) Ficolin-1	OLFM1^c, FCN1^c, NELFB^c	rs10858300 9:137,842,500	6.2×10^-17 replicated
242 Top	RAP (trans) alpha-2-macroglobulin receptor-associated protein	MOG^ab, ZFP57^a, PPP1R11^b, HLA-F^b, HLA-A^b [1 more]GABBR1^b	rs9468569 6:29,623,315	9.6×10^-17
243 Top	PCSK7 (cis) Proprotein convertase subtilisin/kexin type 7	SIK3^ac, BACE1^b, TAGLN^c, APOA1^c, PCSK7^c [2 more]SIDT2^c, BUD13^c	rs4938330 11:116,928,514	9.9×10^-17 replicated		unspecified application
244 Top	CPNE1 (cis) Copine-1	UQCC1^ac, GDF5^ac, ERGIC3^bc, CPNE1^bc, CEP250^bc [13 more]	rs1204656 20:33,982,846	1×10^-16 replicated
245 Top	MICA (cis) MHC class I polypeptide-related sequence A	NOTCH4^ac, HLA-DQB1^bc, GPSM3^a, ATF6B^b, C2^b [23 more]	rs3134942 6:32,168,771	1.2×10^-16		safety
246 Top	C7 (cis) Complement component C7	C7^ae	rs13157656 5:40,964,852	1.3×10^-16 replicated
247 Top	IL-18 Ra (cis) Interleukin-18 receptor 1	SLC9A4^a, IL18RAP^c	rs2871473 2:103,107,280	1.4×10^-16
248 Top	CYTT (cis) Cystatin-SA	CST4^ab, CST1^ac, CSTL1^b, CST8^b, CST11^b [2 more]GGTLC1^b, CST3^c	rs7263120 20:23,690,021	2.3×10^-16 replicated
248	CYTN (cis) Cystatin-SN	CST4^ab, CST1^ac, CSTL1^b, CST8^b, CST11^b [2 more]GGTLC1^b, CST3^c	rs7263120 20:23,690,021	9.6×10^-13
249 Top	TIG2 (cis) Retinoic acid receptor responder protein 2	LRRC61^ac, ZBED6CL^ac, RARRES2^c, REPIN1^c, ACTR3C^c	rs9640161 7:150,045,910	3×10^-16
250 Top	Hemopexin (trans)	ZBTB41^a, CFHR3^c	rs10754218 1:197,165,014	3.2×10^-16
251 Top	IL-23 R (cis) Interleukin-23 receptor	IL23R^ae, C1orf141^a	rs11209026 1:67,705,958	3.4×10^-16
252 Top	ARSB (cis) Arylsulfatase B	ARSB^ac, BHMT^c	rs672413 5:78,278,229	3.6×10^-16
253 Top	MICB (cis) MHC class I polypeptide-related sequence B	HIST1H4J^abc, ZKSCAN3^abc, OR2B2^abe, HIST1H2BL^ab, HIST1H2AI^ab [37 more]	rs33932084 6:28,268,824	4.2×10^-16		safety
254 Top	Galectin-3 (cis)	LGALS3^abe, FBXO34^ace, DLGAP5^a, AL158801.1^a, ATG14^a [3 more]TBPL2^a, SOCS4^c, KTN1^c	rs35070799 14:55,818,403	4.5×10^-16		diagnosis, unspecified application
255 Top	PPAC (cis) Low molecular weight phosphotyrosine protein phosphatase	SH3YL1^c	rs12475664 2:309,097	4.6×10^-16 replicated
256 Top	C4 (cis) Complement C4	ABHD16A^a, XXbac-BPG32J3.20^a, LY6G5C^c, OR10C1^c	rs805273 6:31,665,452	5.1×10^-16 replicated
257 Top	MBL (cis) Mannose-binding protein C	MBL2^a	rs2506 10:54,525,509	5.5×10^-16 replicated		diagnosis
258 Top	RELT (cis) Tumor necrosis factor receptor superfamily member 19L	RELT^abc, FAM168A^ac, ARHGEF17^bc, P2RY2^b, P2RY6^b [1 more]RAB6A^b	rs7119167 11:73,228,685	5.7×10^-16
259 Top	C1s (trans) Complement C1s subcomponent	CFH^ac, CFHR2^a, CFHR4^a, CFHR2^a, KCNT2^b [4 more]	rs12734260 1:196,865,417	5.7×10^-16	SERPING1
260 Top	MICB (cis) MHC class I polypeptide-related sequence B	MICB^ac, MUC22^c, HCG27^c, LST1^c, HLA-DRB5^c [1 more]HLA-C^c	rs2534674 6:31,465,103	6.9×10^-16		safety
261 Top	PLXC1 (cis) Plexin-C1	PLXNC1^ae, UBE2N^c	rs7972001 12:94,623,502	7.8×10^-16
262 Top	Calcineurin (cis)	BANK1^ac	rs17266357 4:102,721,809	8.7×10^-16	cyclosporin A
263 Top	MICA (cis) MHC class I polypeptide-related sequence A	HLA-C^ac, CCHCR1^bc, SFTA2^b, DDAH2^b, PRRC2A^b [15 more]	rs28367631 6:31,267,936	9.8×10^-16 replicated		safety
264 Top	GOT1 (trans) Aspartate aminotransferase, cytoplasmic	sentinel not in SNiPA's database	rs11292716 7:94,935,199	1.2×10^-15
264	LCMT1 (trans) Leucine carboxyl methyltransferase 1	sentinel not in SNiPA's database	rs11292716 7:94,935,199	5.1×10^-15
265 Top	Kallikrein 7 (cis) Kallikrein-7	KLK7^abc	rs2659067 19:51,485,622	1.2×10^-15		diagnosis
266 Top	FCG2A/B (cis) Low affinity immunoglobulin gamma Fc region receptor II-a/b	FCGR2A^a, HSPA6^a, FCGR3A^a	rs34436026 1:161,519,440	1.5×10^-15
267 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	PMFBP1^abce, DHX38^ac, HPR^c, DHODH^c, HP^c [1 more]TXNL4B^c	rs11645898 16:72,229,532	1.5×10^-15		diagnosis, efficacy, unspecified application
268 Top	ADAMTS-5 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 5		rs990529 21:28,346,546	1.6×10^-15
269 Top	sTie-1 (trans) Tyrosine-protein kinase receptor Tie-1, soluble	ABO^ac, DBH^b, ADAMTSL2^b, SARDH^b, RALGDS^b [1 more]MED22^c	rs630510 9:136,149,581	1.6×10^-15 replicated
270 Top	alpha-1-antichymotrypsin complex (cis)	SERPINA3^a, SERPINA3^a	rs6575449 14:95,097,303	1.9×10^-15		unspecified application
270	a1-Antichymotrypsin (cis) Alpha-1-antichymotrypsin	SERPINA3^a, SERPINA3^a	rs6575449 14:95,097,303	3.2×10^-12		unspecified application
271 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICA^ac, MICB^c, TNXB^c, PSORS1C2^c	rs4418214 6:31,391,401	2.2×10^-15		safety
272 Top	gp130, soluble (cis) Interleukin-6 receptor subunit beta	IL6ST^abce, AC008914.1^a, ANKRD55^b, DDX4^b, SLC38A9^b	rs7730934 5:55,266,512	2.6×10^-15 replicated		unspecified application
273 Top	IL-6 sRa (cis) Interleukin-6 receptor subunit alpha	HAX1^c, UBAP2L^c, S100A4^c, IL6R^c	rs12121180 1:154,282,222	2.6×10^-15	tocilizumab	efficacy
274 Top	ETHE1 (trans) Persulfide dioxygenase ETHE1, mitochondrial	FETUB^a	rs3733159 3:186,360,409	3×10^-15
274	FETUB (cis) Fetuin-B	FETUB^a	rs3733159 3:186,360,409	1.4×10^-9
275 Top	GPC5 (cis) Glypican-5	GPC5^ac	rs7325116 13:92,592,555	3.4×10^-15
276 Top	MASP3 (trans) Mannan-binding lectin serine protease 1	ZNF385B^c	rs259842 2:180,738,840	3.5×10^-15
277 Top	MICB (cis) MHC class I polypeptide-related sequence B	C6orf15^ac, PSORS1C1^ac, CDSN^a, FLOT1^b, HCG27^c [7 more]	rs3130991 6:31,087,354	3.6×10^-15		safety
278 Top	TECK (cis) C-C motif chemokine 25	ELAVL1^a	rs6603134 19:8,106,521	4.1×10^-15 replicated		disease progression
279 Top	TARC (cis) C-C motif chemokine 17	CCL17^a	rs9302690 16:57,442,968	4.2×10^-15
280 Top	CNDP1 (cis) Beta-Ala-His dipeptidase	CNDP1^ac	rs17817077 18:72,209,543	4.7×10^-15
281 Top	Haptoglobin, Mixed Type (cis) Haptoglobin	AC010547.9^ac, ZNF19^a, MARVELD3^c, ZNF23^c	rs8049040 16:71,472,704	5.5×10^-15 replicated		diagnosis, efficacy, unspecified application
282 Top	a1-Antitrypsin (cis) Alpha-1-antitrypsin	SERPINA1^ab, SERPINA9^b	rs2749534 14:94,809,760	5.6×10^-15		diagnosis, unspecified application
283 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICA^a	rs17200067 6:31,370,722	5.8×10^-15		safety
284 Top	LAG-1 (cis) C-C motif chemokine 4-like		rs3213636 17:34,475,131	6.1×10^-15
285 Top	MICA (cis) MHC class I polypeptide-related sequence A	DXO^c, LST1^c, HLA-B^c, AGER^c, MICB^c [1 more]PSMB8^c	rs2523710 6:31,450,909	6.5×10^-15		safety
286 Top	Angiogenin (cis)	RP11-903H12.5^ac, RNASE4^ac, ANG^ac	rs1888560 14:21,164,245	6.7×10^-15 replicated		response to therapy
287 Top	sLeptin R (cis) Leptin receptor	LEPR^a	rs4655537 1:66,058,801	7.4×10^-15 replicated	recombinant-methionyl human leptin	prognosis
288 Top	Kininogen, HMW (cis) Kininogen-1	KNG1^a	rs3856930 3:186,458,322	7.6×10^-15
289 Top	Carbonic anhydrase 6 (cis)		rs6665631 1:8,978,514	8.1×10^-15	methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, chlorothiazide, chlorthalidone, benzthiazide, sulfacetamide, topiramate
290 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	CAST^ac, ERAP1^c	rs6556937 5:95,985,282	8.4×10^-15
291 Top	Plasminogen (cis)	PLG^ab, AGPAT4^b	rs783150 6:161,226,939	8.7×10^-15	tenecteplase, PLAT, tranexamic acid, aprotinin, 6-aminocaproic acid, reteplase	diagnosis
292 Top	HCG (cis) Human Chorionic Gonadotropin	RUVBL2^ac, CGB^ac, LHB^a, CTB-60B18.6^a, NUCB1^b	rs753307 19:49,518,484	9.4×10^-15
293 Top	Cystatin C (cis) Cystatin-C	CST3^abce, CST9^ac, CST5^b, CSTL1^b, CST8^b [4 more]	rs6036478 20:23,611,359	9.6×10^-15		diagnosis, efficacy, prognosis, safety, unspecified application
294 Top	RET (cis) Proto-oncogene tyrosine-protein kinase receptor Ret	CCNYL2^b, HNRNPF^b, BMS1^b, RASGEF1A^b, RET^b [1 more]ANKRA2^d	rs2795502 10:43,340,662	1×10^-14	sunitinib, motesanib, cabozantinib, regorafenib, ponatinib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, cabozantinib/erlotinib, imatinib/nilotinib/pegintron, imatinib, sorafenib, vandetanib	efficacy, response to therapy
295 Top	MICB (cis) MHC class I polypeptide-related sequence B	LST1^c, PSORS1C2^c, HLA-C^c, AIF1^c, CCHCR1^c [3 more]MICB^c, PSORS1C1^c, VARS2^c	rs2284178 6:31,432,125	1.1×10^-14 replicated		safety
296 Top	IL-6 sRa (cis) Interleukin-6 receptor subunit alpha	IL6R^c	rs9427116 1:154,631,123	1.1×10^-14	tocilizumab	efficacy
297 Top	DERM (cis) Dermatopontin	DPT^abc	rs494189 1:168,707,757	1.1×10^-14 replicated
298 Top	Nidogen (trans) Nidogen-1	PLXDC2^a	rs9651367 10:20,223,450	1.2×10^-14
299 Top	Granulysin (cis)	GNLY^ac, ATOH8^c	rs6547631 2:85,909,026	1.2×10^-14 replicated
300 Top	IL-1Rrp2 (cis) Interleukin-1 receptor-like 2	IL1RL2^ac	rs1922291 2:102,828,817	1.3×10^-14
301 Top	complement factor H-related 5 (cis) Complement factor H-related protein 5	ASPM^ab, ZBTB41^ac, CFHR1^bc, CFHR3^bc, F13B^ae [6 more]	rs6003 1:197,031,021	1.5×10^-14
302 Top	ARTS1 (cis) Endoplasmic reticulum aminopeptidase 1	LNPEP^a, ERAP2^c	rs27303 5:96,374,150	1.5×10^-14
303 Top	NPS-PLA2 (cis) Phospholipase A2, membrane associated	PLA2G5^a, MRTO4^c, OTUD3^c	rs17354650 1:20,390,322	1.7×10^-14 replicated	varespladib methyl, varespladib, indomethacin	efficacy, prognosis, safety
304 Top	CLM6 (trans) CMRF35-like molecule 6	POC1B-GALNT4^ace, GALNT4^ace, POC1B^ac, ATP2B1^c	rs722414 12:89,937,437	2.3×10^-14 replicated
305 Top	Esterase D (cis) S-formylglutathione hydrolase	HTR2A^a	rs6561333 13:47,420,312	2.7×10^-14
306 Top	RUXF (trans) Small nuclear ribonucleoprotein F	APOC1^a	rs4420638 19:45,422,946	3×10^-14
306	Apo E2 (cis) Apolipoprotein E (isoform E2)	APOC1^a	rs4420638 19:45,422,946	1.9×10^-13		diagnosis, efficacy, prognosis, unspecified application
307 Top	Elafin (cis)	PI3^abce, SEMG2^abe, SEMG1^ac, SLPI^ac, WFDC5^bc [13 more]	rs6032067 20:43,864,809	3.2×10^-14 replicated
308 Top	DLRB1 (trans) Dynein light chain roadblock-type 1	TRIM58^ac, OR2W3^c, OR2T8^c	rs3737276 1:248,024,073	3.6×10^-14
309 Top	IL-15 Ra (cis) Interleukin-15 receptor subunit alpha	IL15RA^ac, GDI2^b	rs7097780 10:6,010,227	3.8×10^-14		prognosis
310 Top	CD23 (cis) Low affinity immunoglobulin epsilon Fc receptor	FCER2^ac, CCL25^b	rs11260013 19:7,759,676	3.9×10^-14 replicated		diagnosis
311 Top	I-TAC (cis) C-X-C motif chemokine 11	ART3^abc, CXCL11^abc, CXCL9^ab, CXCL10^ac, NAAA^bc [8 more]	rs4356932 4:76,955,194	4.3×10^-14
312 Top	RGM-C (trans) Hemojuvelin	NPR2^ac, SPAG8^ac, TMEM8B^ac, HINT2^a, FAM221B^a [4 more]GBA2^c, MSMP^c, HRCT1^c, TPM2^c	rs2236293 9:35,841,783	4.6×10^-14
313 Top	MSP (cis) Hepatocyte growth factor-like protein	CDC25A^ac, ZNF589^ac, CAMP^a, UQCRC1^b, MAP4^b [11 more]	rs6442112 3:48,316,034	4.7×10^-14
314 Top	C7 (cis) Complement component C7	PTGER4^c	rs7713972 5:40,552,474	5.2×10^-14
315 Top	IGF-II receptor (cis) Cation-independent mannose-6-phosphate receptor	SLC22A1^ac, MAS1^c	rs9295123 6:160,570,114	5.3×10^-14 replicated
316 Top	MMP-7 (cis) Matrilysin	MMP7^ac	rs11568819 11:102,401,633	5.8×10^-14	marimastat	diagnosis
317 Top	PCSK7 (cis) Proprotein convertase subtilisin/kexin type 7	RNF214^ac, PCSK7^ac, BACE1^ac, TAGLN^c, SIDT2^c	rs7083 11:117,156,552	6.3×10^-14		unspecified application
318 Top	ARSB (cis) Arylsulfatase B	ARSB^ac	rs6865582 5:78,201,833	7.2×10^-14
319 Top	Haptoglobin, Mixed Type (cis) Haptoglobin		rs8044476 16:72,800,567	7.7×10^-14		diagnosis, efficacy, unspecified application
320 Top	a1-Antitrypsin (cis) Alpha-1-antitrypsin	SERPINA6^a, SERPINA1^c	rs4905179 14:94,795,492	7.7×10^-14		diagnosis, unspecified application
321 Top	annexin II (cis) Annexin A2		rs338419 15:60,517,276	7.7×10^-14		diagnosis, unspecified application
322 Top	C1-Esterase Inhibitor (cis) Plasma protease C1 inhibitor	SLC43A1^abc, SMTNL1^ac, YPEL4^bc, ZDHHC5^bc, UBE2L6^a [8 more]	rs2729354 11:57,355,970	8×10^-14
323 Top	GPNMB (cis) Transmembrane glycoprotein NMB	GPNMB^ac, KLHL7^c, NUPL2^c	rs5850 7:23,314,547	8.1×10^-14		unspecified application
324 Top	Angiogenin (cis)	RP11-903H12.5^c, RNASE6^c, ANG^c	rs11624221 14:21,128,050	8.6×10^-14		response to therapy
325 Top	sLeptin R (cis) Leptin receptor	LEPR^ac, DNAJC6^b, AK4^b, LEPROT^c	rs17412403 1:65,942,266	8.7×10^-14 replicated	recombinant-methionyl human leptin	prognosis
326 Top	complement factor H-related 5 (cis) Complement factor H-related protein 5	CFH^a	rs35908703 1:196,692,940	8.8×10^-14
326	Factor H (cis) Complement factor H	CFH^a	rs35908703 1:196,692,940	5.7×10^-12		unspecified application
327 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a	rs5754266 22:33,172,005	1.2×10^-13		diagnosis, prognosis, unspecified application
328 Top	MP2K2 (trans) Dual specificity mitogen-activated protein kinase kinase 2	PCID2^ac, CUL4A^a	rs9577481 13:113,860,900	1.2×10^-13	selumetinib, trametinib, dabrafenib/trametinib
329 Top	PDGF Rb (cis) Platelet-derived growth factor receptor beta	CSF1R^ac, PDGFRB^c	rs11746309 5:149,479,647	1.2×10^-13	nilotinib, dasatinib, sunitinib, pazopanib, axitinib, tivozanib, tandutinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, imatinib, sorafenib, becaplermin	prognosis, response to therapy, unspecified application
330 Top	MICB (cis) MHC class I polypeptide-related sequence B	BTN3A3^abc, BTN1A1^abe, HMGN4^ab, ABT1^ab, BTN3A2^bc [17 more]	rs35555795 6:26,509,382	1.3×10^-13		safety
331 Top	FCN2 (cis) Ficolin-2	FCN1^a	rs2989736 9:137,797,175	1.3×10^-13
332 Top	NKG2D (cis) NKG2-D type II integral membrane protein	KLRK1^abce, KLRC3^abc, KLRC2^abc, KLRC4-KLRK1^ace, KLRC1^ac [7 more]	rs2255336 12:10,532,326	1.3×10^-13
333 Top	BCAR3 (trans) Breast cancer anti-estrogen resistance protein 3	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	1.3×10^-13
333	OCAD1 (trans) OCIA domain-containing protein 1	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	3.4×10^-13
333	Macrophage scavenger receptor (trans) Macrophage scavenger receptor types I and II	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	9.3×10^-12
333	ABL2 (trans) Abelson tyrosine-protein kinase 2	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	2.2×10^-10
333	TYK2 (trans) Non-receptor tyrosine-protein kinase TYK2	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	5.8×10^-9
333	DRAK2 (trans) Serine/threonine-protein kinase 17B	TMEM97^c, TMEM199^c, SARM1^c	rs9901901 17:26,610,513	8.7×10^-9
334 Top	TXD12 (trans) Thioredoxin domain-containing protein 12	sentinel not in SNiPA's database	rs35365539 3:49,794,348	1.4×10^-13
335 Top	CATZ (trans) Cathepsin Z	GNPTAB^a, CCDC53^b, CHPT1^c, DRAM1^c	rs10860794 12:102,217,720	1.4×10^-13
335	Cathepsin A (trans) Lysosomal protective protein	GNPTAB^a, CCDC53^b, CHPT1^c, DRAM1^c	rs10860794 12:102,217,720	2.2×10^-11
336 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a	rs5754249 22:33,147,526	1.7×10^-13		diagnosis, prognosis, unspecified application
337 Top	ASAHL (cis) N-acylethanolamine-hydrolyzing acid amidase	NAAA^ac, ART3^b, CXCL9^b, SDAD1^b, PPEF2^c [1 more]CDKL2^c	rs1513890 4:76,835,364	1.8×10^-13
338 Top	MICA (cis) MHC class I polypeptide-related sequence A	MUC22^a, HCG27^c, PSORS1C2^c, MICA^c, CCHCR1^c [2 more]VARS2^c, PSORS1C1^c	rs11753208 6:31,005,432	2×10^-13		safety
339 Top	PDGF Rb (cis) Platelet-derived growth factor receptor beta	PDGFRB^a	rs17708574 5:149,521,238	2.2×10^-13 replicated	nilotinib, dasatinib, sunitinib, pazopanib, axitinib, tivozanib, tandutinib, nintedanib, regorafenib, bortezomib/sorafenib, lapatinib/pazopanib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, imatinib, sorafenib, becaplermin	prognosis, response to therapy, unspecified application
340 Top	GPC5 (cis) Glypican-5	GPC5^ac	rs2147190 13:92,058,888	2.3×10^-13
341 Top	IL-18 Ra (cis) Interleukin-18 receptor 1	sentinel not in SNiPA's database	rs6725806 2:103,216,172	2.4×10^-13
342 Top	MICA (cis) MHC class I polypeptide-related sequence A	TRIM31^abce, TRIM40^a, HLA-F^c, HLA-DQA1^c, HLA-DQB1^c [10 more]	rs2523987 6:30,079,993	2.4×10^-13		safety
343 Top	DKK3 (cis) Dickkopf-related protein 3	MICALCL^b, DKK3^c, USP47^c	rs11022119 11:12,050,652	2.8×10^-13
344 Top	ASAH2 (cis) Neutral ceramidase		rs2338747 10:48,005,276	3.3×10^-13
345 Top	Plasminogen (cis)	AGPAT4^b	rs2565722 6:161,235,142	3.9×10^-13	tenecteplase, PLAT, tranexamic acid, aprotinin, 6-aminocaproic acid, reteplase	diagnosis
346 Top	MAPK2 (cis) MAP kinase-activated protein kinase 2	IL19^bc, MAPKAPK2^a, IKBKE^b	rs6669284 1:206,890,435	3.9×10^-13
347 Top	Cripto (cis) Teratocarcinoma-derived growth factor 1	LRRC2^ac, TDGF1^c	rs939421 3:46,576,081	4×10^-13		diagnosis
348 Top	Trypsin 2 (trans) Trypsin-2	TRBV30^ac, TRBV3-1^b, TRBJ2-2^b, TRBV27^b, TRBV4-1^b [17 more]	rs3134906 7:142,505,154	4.2×10^-13
349 Top	DC-SIGN (cis) CD209 antigen	CLEC4G^ac, C19orf45^b, CCL25^b, TGFBR3L^c, XAB2^c [3 more]FCER2^c, MCEMP1^c, CD209^c	rs8106657 19:7,788,091	4.2×10^-13
350 Top	MMP-8 (trans) Neutrophil collagenase	C6orf48^ab, HSPA1L^ae, LSM2^a, HSPA1A^a, NEU1^a [3 more]SLC44A4^a, CFB^b, AGER^b	rs2227955 6:31,778,077	4.2×10^-13	marimastat	efficacy
350	C34 gp41 HIV Fragment (trans) gp41 C34 peptide, HIV	C6orf48^ab, HSPA1L^ae, LSM2^a, HSPA1A^a, NEU1^a [3 more]SLC44A4^a, CFB^b, AGER^b	rs2227955 6:31,778,077	3.8×10^-9
351 Top	sICAM-5 (cis) Intercellular adhesion molecule 5	TYK2^bc, PDE4A^ae, ZGLP1^b, PPAN-P2RY11^b, KRI1^b [6 more]	rs1051738 19:10,577,843	4.6×10^-13
352 Top	6Ckine (trans) C-C motif chemokine 21	DNAJC13^abc, ACAD11^abe, NPHP3^ac, NPHP3-ACAD11^a, ACKR4^a [1 more]UBA5^a	rs17412738 3:132,257,419	5.3×10^-13 replicated		disease progression
353 Top	IMDH1 (trans) Inosine-5'-monophosphate dehydrogenase 1	ARHGEF3^ab, CCDC66^b	rs1354034 3:56,849,749	5.4×10^-13	thioguanine, VX-944, pegintron/ribavirin, PEG-interferon alfa-2a/ribavirin, nitazoxanide/peginterferon alfa-2a/ribavirin, interferon alfa-2b/ribavirin, mycophenolate mofetil, mycophenolic acid, ribavirin
353	DLRB1 (trans) Dynein light chain roadblock-type 1	ARHGEF3^ab, CCDC66^b	rs1354034 3:56,849,749	6.1×10^-11
353	AMPM2 (trans) Methionine aminopeptidase 2	ARHGEF3^ab, CCDC66^b	rs1354034 3:56,849,749	1.2×10^-9	nitroxoline, beloranib, PPI-2458	unspecified application
354 Top	sE-Selectin (trans) E-Selectin	ABO^ac, SURF6^c	rs8176720 9:136,132,873	5.8×10^-13		diagnosis, disease progression, efficacy, unspecified application
354	ATS13 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 13	ABO^ac, SURF6^c	rs8176720 9:136,132,873	6.4×10^-10
354	IR (trans) Insulin receptor	ABO^ac, SURF6^c	rs8176720 9:136,132,873	7.4×10^-10 replicated	insulin detemir, INS, canakinumab/INS, insulin aspart/insulin detemir, ceritinib, insulin glargine/insulin lispro, insulin aspart, insulin glulisine, insulin lispro, insulin glargine, protamine zinc insulin	prognosis
355 Top	GPVI (cis) Platelet glycoprotein VI	RDH13^a, KIR3DL2^b, KIR3DL1^b, LILRA1^b, KIR2DL3^b [9 more]	rs11672111 19:55,565,634	6.8×10^-13
356 Top	MP2K4 (trans) Dual specificity mitogen-activated protein kinase kinase 4	sentinel not in SNiPA's database	rs10127775 1:230,295,789	6.9×10^-13
357 Top	Apo B (cis) Apolipoprotein B	APOB^ae	rs520354 2:21,259,612	6.9×10^-13	mipomersen	diagnosis, efficacy
358 Top	IGF-II receptor (cis) Cation-independent mannose-6-phosphate receptor	IGF2R^ac, MAS1^a, TCP1^b, SOD2^b, SLC22A1^c [1 more]WTAP^c	rs12202350 6:160,379,096	7.1×10^-13
359 Top	PARC (cis) C-C motif chemokine 18		rs35871176 17:34,375,832	7.3×10^-13		efficacy, safety
360 Top	VEGF sR3 (trans) Vascular endothelial growth factor receptor 3	DCBLD2^c, ST3GAL6^c	rs13318932 3:98,396,350	8×10^-13	sunitinib, pazopanib, axitinib, CEP 7055, tivozanib, motesanib, telatinib, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, sorafenib, vandetanib	diagnosis, disease progression, efficacy, prognosis
361 Top	ASAH2 (cis) Neutral ceramidase		rs12411860 10:52,038,032	8×10^-13
362 Top	MAPKAPK3 (trans) MAP kinase-activated protein kinase 3	LCP1^a	rs9534338 13:46,707,137	8×10^-13		unspecified application
363 Top	GPNMB (cis) Transmembrane glycoprotein NMB	GPNMB^ab, KLHL7^a, TOMM7^b	rs858267 7:23,210,129	8.4×10^-13		unspecified application
364 Top	CNTN2 (cis) Contactin-2	NFASC^ab, LRRN2^b, TMCC2^b	rs3795559 1:204,989,911	8.4×10^-13 replicated
365 Top	C8 (cis) Complement component C8	C8B^ae	rs1013579 1:57,422,484	9.3×10^-13
365	NXPH1 (trans) Neurexophilin-1	C8B^ae	rs1013579 1:57,422,484	1×10^-10
366 Top	MIP-5 (cis) C-C motif chemokine 15	CCL14^a, CCL15-CCL14^a, CCL15^a, CCL23^a	rs2056492 17:34,318,565	9.9×10^-13
367 Top	HRG (cis) Histidine-rich glycoprotein	KNG1^ac	rs1403694 3:186,439,998	1.2×10^-12
368 Top	TFF3 (trans) Trefoil factor 3	NFKBIL1^a, SKIV2L^c, TCF19^c, PSORS1C2^c	rs2524277 6:31,407,579	1.2×10^-12		diagnosis, unspecified application
369 Top	LD78-beta (cis) C-C motif chemokine 3-like 1	CCL18^a	rs16971895 17:34,386,399	1.2×10^-12
370 Top	KI2L4 (cis) Killer cell immunoglobulin-like receptor 2DL4	FCAR^a	rs7259090 19:55,392,646	1.3×10^-12
371 Top	ATS13 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 13	SURF6^a, MED22^a	rs4962130 9:136,195,607	1.3×10^-12
372 Top	C4 (cis) Complement C4	HLA-DRA^abc, CYP21A2^bc, C4B^bc, PSMB9^bc, HLA-DOB^bc [24 more]	rs2239805 6:32,411,376	1.4×10^-12
373 Top	HCC-1 (cis) C-C motif chemokine 14	CCL14^c, CCL15-CCL14^c, CCL23^c	rs854658 17:34,352,666	1.5×10^-12
374 Top	ECM1 (cis) Extracellular matrix protein 1	TARS2^abc, PRPF3^ab, RPRD2^ac, ECM1^ac, CTSS^bc [8 more]	rs12724450 1:150,480,571	1.6×10^-12		diagnosis
375 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	CD38^ac, FBXL5^c	rs4473651 4:15,770,911	1.6×10^-12
376 Top	MSP (cis) Hepatocyte growth factor-like protein	MAPKAPK3^ac, DOCK3^a, HYAL3^c, NAT6^c, WDR6^c [3 more]C3orf62^c, USP4^c, RPL29^c	rs9869826 3:50,998,816	1.8×10^-12
377 Top	TARC (trans) C-C motif chemokine 17	PLCL2^abc	rs983545 3:16,959,652	2.3×10^-12
378 Top	Plasminogen (cis)	MAP3K4^ac	rs3798911 6:161,465,297	2.5×10^-12	tenecteplase, PLAT, tranexamic acid, aprotinin, 6-aminocaproic acid, reteplase	diagnosis
379 Top	C4b (cis) Complement C4b	TNXB^ab, ATF6B^a, FKBPL^a, CFB^b, PRRC2A^b [5 more]	rs204888 6:32,089,142	2.5×10^-12
380 Top	FN1.3 (cis) Fibronectin Fragment 3	sentinel not in SNiPA's database	rs35233997 2:216,238,970	2.5×10^-12	ocriplasmin	diagnosis, efficacy, prognosis, unspecified application
381 Top	SIG14 (cis) Sialic acid-binding Ig-like lectin 14		rs17660992 19:52,163,948	2.6×10^-12 replicated
382 Top	BST1 (cis) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	BST1^a	rs1110258 4:15,742,716	2.7×10^-12
383 Top	ADAMTS-5 (cis) A disintegrin and metalloproteinase with thrombospondin motifs 5	ADAMTS1^a, GABPA^c	rs229100 21:28,223,092	2.9×10^-12
384 Top	Afamin (cis)	AFM^abe, RASSF6^ac, AFP^b	rs41265665 4:74,361,142	3×10^-12 replicated
385 Top	Siglec-9 (cis) Sialic acid-binding Ig-like lectin 9	KLK14^a	rs3745542 19:51,587,643	3.1×10^-12
386 Top	IL-18 Ra (cis) Interleukin-18 receptor 1	IL1RL2^a, IL1RL1^c, IL18R1^c	rs9646944 2:102,865,875	3.2×10^-12
387 Top	granzyme A (trans) Granzyme A	HLA-C^ac, HLA-B^ac, TCF19^c, VARS2^c, HCG27^c [16 more]	rs2853928 6:31,257,511	3.4×10^-12
388 Top	EPHB2 (cis) Ephrin type-B receptor 2	EPHB2^ac, C1QA^b, C1QB^b	rs6687487 1:23,061,551	3.5×10^-12		unspecified application
389 Top	ASAHL (trans) N-acylethanolamine-hydrolyzing acid amidase	CHPT1^ac, MYBPC1^a, GNPTAB^c	rs2559856 12:102,089,561	3.6×10^-12
390 Top	PDE5A (cis) cGMP-specific 3',5'-cyclic phosphodiesterase	C4orf3^ac, FABP2^ac, PDE5A^c, USP53^c	rs4834770 4:120,241,849	3.6×10^-12	dyphylline, nitroglycerin, udenafil, avanafil, aspirin/dipyridamole/telmisartan, aminophylline, sildenafil, dipyridamole, aspirin/dipyridamole, vardenafil, tolbutamide, tadalafil, theophylline, pentoxifylline	diagnosis
391 Top	Coagulation Factor XI (cis)	CYP4V2^ac, KLKB1^ac, F11^b, FAT1^b	rs6842047 4:187,133,576	3.7×10^-12
392 Top	Siglec-9 (cis) Sialic acid-binding Ig-like lectin 9	CTU1^a, SHANK1^b, SIGLEC9^c	rs17801525 19:51,615,155	3.9×10^-12 replicated
393 Top	C7 (cis) Complement component C7	C7^abe, C6^c	rs10473230 5:40,982,031	3.9×10^-12
394 Top	HRG (cis) Histidine-rich glycoprotein		rs1846899 3:186,472,816	4×10^-12
395 Top	MIP-5 (cis) C-C motif chemokine 15	CCL15-CCL14^a, CCL15^a	rs2075746 17:34,325,532	4.3×10^-12 replicated
396 Top	MFGM (cis) Lactadherin	MFGE8^abc, HAPLN3^ac	rs3743392 15:89,445,651	4.8×10^-12
397 Top	IL-17E (trans) Interleukin-25	POU2F3^a	rs7121784 11:120,159,052	5.3×10^-12
398 Top	IL-1Rrp2 (cis) Interleukin-1 receptor-like 2	IL1R1^abe, IL1RL2^ab, IL1RL1^b	rs4851551 2:102,800,230	5.8×10^-12
399 Top	CYTD (cis) Cystatin-D	CST2^ac, CST1^c	rs4585101 20:23,847,254	5.9×10^-12
400 Top	Carbonic anhydrase 6 (cis)	CA6^abe, RERE^b	rs3765967 1:9,011,627	6.1×10^-12 replicated	methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, chlorothiazide, chlorthalidone, benzthiazide, sulfacetamide, topiramate
401 Top	PIGR (cis) Polymeric immunoglobulin receptor	sentinel not in SNiPA's database	rs35400166 1:207,064,011	6.3×10^-12 replicated		unspecified application
402 Top	SPARCL1 (cis) SPARC-like protein 1	SPARCL1^c, HSD17B13^c	rs1462372 4:88,478,750	6.3×10^-12 replicated		disease progression
403 Top	HGFA (cis) Hepatocyte growth factor activator	RGS12^ab, SH3BP2^b, HGFAC^b, ADRA2C^b, ADD1^b [2 more]LRPAP1^b, MFSD10^b	rs3135063 4:3,287,052	6.7×10^-12
404 Top	GOT1 (trans) Aspartate aminotransferase, cytoplasmic	PON1^ac, ASB4^c, PON2^c	rs757158 7:94,955,528	7×10^-12
405 Top	CYTF (cis) Cystatin-F	CST7^b, PYGB^b, ACSS1^b, ABHD12^c	rs6050091 20:24,873,553	7.5×10^-12
406 Top	ESAM (cis) Endothelial cell-selective adhesion molecule	VSIG2^ac, NRGN^a, ESAM^a, MSANTD2^c	rs11219769 11:124,620,147	7.8×10^-12 replicated
407 Top	MICA (cis) MHC class I polypeptide-related sequence A	MICB^a, MCCD1^a, ATP6V1G2^a, ATP6V1G2-DDX39B^a, NFKBIL1^a [2 more]LST1^a, NCR3^a	rs17200698 6:31,483,700	1.1×10^-11		safety
408 Top	IL-1 R4 (cis) Interleukin-1 receptor-like 1	IL18R1^abc, IL1RL1^abc, IL18RAP^a, IL1R1^b	rs3771167 2:102,986,188	1.1×10^-11
409 Top	IL-1 R4 (cis) Interleukin-1 receptor-like 1	IL1R1^a	rs3917254 2:102,776,518	1.2×10^-11
410 Top	MAPKAPK3 (trans) MAP kinase-activated protein kinase 3	CPB2^a, ZC3H13^c	rs17844003 13:46,670,347	1.2×10^-11		unspecified application
411 Top	MAPKAPK3 (trans) MAP kinase-activated protein kinase 3	ZC3H13^a	rs12585823 13:46,536,291	1.2×10^-11		unspecified application
412 Top	C1-Esterase Inhibitor (cis) Plasma protease C1 inhibitor	OR9Q1^a, OR9I1^a, OR5B21^b, LPXN^b, ZDHHC5^b [2 more]MED19^c, TIMM10^c	rs12788387 11:57,893,347	1.5×10^-11
413 Top	Coagulation Factor V (cis)	F5^ae	rs9332653 1:169,490,772	1.6×10^-11 replicated	drotrecogin alfa, antithrombin alfa	diagnosis
413	CAMK1 (trans) Calcium/calmodulin-dependent protein kinase type 1	F5^ae	rs9332653 1:169,490,772	1.9×10^-11 replicated
414 Top	RET (cis) Proto-oncogene tyrosine-protein kinase receptor Ret	RET^bc, CCNYL2^b	rs2506028 10:43,444,534	1.8×10^-11	sunitinib, motesanib, cabozantinib, regorafenib, ponatinib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, imatinib/sirolimus, cabozantinib/erlotinib, imatinib/nilotinib/pegintron, imatinib, sorafenib, vandetanib	efficacy, response to therapy
415 Top	IL-1 R4 (cis) Interleukin-1 receptor-like 1	SLC9A4^ab, TMEM182^b, IL18R1^c, IL18RAP^c	rs4851016 2:103,120,400	1.8×10^-11 replicated
416 Top	Caspase-3 (cis)	PRIMPOL^abce, CASP3^ac, ACSL1^b, IRF2^b, CENPU^c	rs870825 4:185,588,045	1.8×10^-11	emricasan	diagnosis, disease progression, efficacy, unspecified application
417 Top	EDAR (trans) Tumor necrosis factor receptor superfamily member EDAR	ZFPM2^a, CXCL5^d	rs16873418 8:106,592,145	1.9×10^-11 replicated
417	Integrin a1b1 (trans) Integrin alpha-I: beta-1 complex	ZFPM2^a, CXCL5^d	rs16873418 8:106,592,145	1.4×10^-9
418 Top	IL-16 (cis) Interleukin-16	IL16^a	rs11072996 15:81,529,410	2.1×10^-11
419 Top	TSG-6 (cis) Tumor necrosis factor-inducible gene 6 protein	TNFAIP6^abe, RBM43^c, NMI^c	rs1046668 2:152,226,570	2.1×10^-11		unspecified application
420 Top	Angiotensinogen (cis)	CAPN9^a	rs2493151 1:230,878,561	2.2×10^-11		efficacy
421 Top	IL-17 sR (cis) Interleukin-17 receptor A	CECR5^a, CECR6^c	rs5994176 22:17,618,164	2.3×10^-11
422 Top	NXPH1 (trans) Neurexophilin-1	C8B^a	rs668555 1:57,426,454	2.4×10^-11
423 Top	MICA (cis) MHC class I polypeptide-related sequence A	TRIM15^abce, TRIM10^abc, TRIM40^ab, TRIM31^a, TRIM26^a [4 more]	rs9368624 6:30,135,977	2.5×10^-11		safety
424 Top	sLeptin R (cis) Leptin receptor	LEPR^ac, LEPROT^c	rs7535099 1:66,050,997	3.1×10^-11	recombinant-methionyl human leptin	prognosis
425 Top	Angiostatin (cis)	LPA^a	rs41265930 6:160,964,135	3.4×10^-11	tenecteplase, PLAT, tranexamic acid, aprotinin, 6-aminocaproic acid, reteplase	diagnosis
426 Top	MMP-8 (trans) Neutrophil collagenase		rs7896471 10:101,788,308	3.4×10^-11	marimastat	efficacy
427 Top	LAG-1 (trans) C-C motif chemokine 4-like	CCR3^abc, CCRL2^abe, CCR2^ab, CCR5^ab, LTF^ab [9 more]	rs6808835 3:46,449,864	3.5×10^-11
428 Top	Siglec-6 (cis) Sialic acid-binding Ig-like lectin 6	SIGLEC6^ae, SIGLEC12^c	rs35931837 19:52,033,158	3.6×10^-11
429 Top	VEGF sR3 (trans) Vascular endothelial growth factor receptor 3	ST3GAL6^a	rs3213958 3:98,487,206	3.7×10^-11	sunitinib, pazopanib, axitinib, CEP 7055, tivozanib, motesanib, telatinib, cabozantinib, nintedanib, regorafenib, bortezomib/sorafenib, dexamethasone/lenalidomide/sorafenib, bevacizumab/sorafenib, cabozantinib/erlotinib, sorafenib, vandetanib	diagnosis, disease progression, efficacy, prognosis
430 Top	PPAC (cis) Low molecular weight phosphotyrosine protein phosphatase	SH3YL1^abc, ACP1^a, FAM150B^a, TMEM18^b	rs300703 2:239,416	3.8×10^-11
431 Top	TIMP-3 (cis) Metalloproteinase inhibitor 3	SYN3^a	rs3788504 22:33,160,397	3.9×10^-11		diagnosis, prognosis, unspecified application
432 Top	CNTN2 (cis) Contactin-2	CNTN2^abc, RBBP5^ac, TMEM81^a, DSTYK^c, TMCC2^c	rs41264869 1:205,030,862	4×10^-11 replicated
433 Top	TARC (trans) C-C motif chemokine 17	ACKR2^ae, KRBOX1^a, CYP8B1^a, RP11-136C24.3^a	rs2228467 3:42,906,116	4.2×10^-11
434 Top	CNTN2 (cis) Contactin-2	NFASC^a	rs2246662 1:204,943,947	4.5×10^-11
435 Top	DERM (cis) Dermatopontin	DPT^ac, TBX19^b	rs530022 1:168,675,971	4.5×10^-11 replicated
436 Top	annexin I (cis) Annexin A1	ANXA1^abc	rs4745216 9:75,744,157	5.2×10^-11	hydrocortisone, hydrocortisone/prednisone, hydrocortisone/mitoxantrone	diagnosis, prognosis, unspecified application
437 Top	EMR2 (cis) EGF-like module-containing mucin-like hormone receptor-like 2	ADGRE5^a	rs7260110 19:14,501,544	5.2×10^-11
438 Top	CAMK1 (trans) Calcium/calmodulin-dependent protein kinase type 1		rs12241254 10:101,329,158	5.3×10^-11
439 Top	IL-1 R AcP (cis) Interleukin-1 Receptor accessory protein	IL1RAP^a	rs9811674 3:190,287,162	5.3×10^-11
440 Top	GFRa-2 (cis) GDNF family receptor alpha-2	NPM2^b, FGF17^b, FAM160B2^b, GFRA2^c	rs10503709 8:21,474,049	5.4×10^-11
441 Top	AK1A1 (cis) Alcohol dehydrogenase [NADP(+)]	MAST2^abc, TESK2^ab, PRDX1^ac, MMACHC^ac, GPBP1L1^ab [9 more]	rs6662572 1:46,146,812	5.8×10^-11
442 Top	sTie-1 (trans) Tyrosine-protein kinase receptor Tie-1, soluble	ABO^ac, SURF1^c, SLC2A6^c, GBGT1^c	rs7857390 9:136,128,546	5.8×10^-11 replicated
443 Top	Cripto (cis) Teratocarcinoma-derived growth factor 1	TDGF1^ac, PRSS50^b, CCR2^b, LRRC2^b, CCR3^b [4 more]	rs7610301 3:46,646,028	5.9×10^-11 replicated		diagnosis
444 Top	SAP (cis) Serum amyloid P-component	APCS^ab, OR10J1^b, OR10J5^b, SLAMF8^b, CADM3^b [3 more]IGSF8^b, CXCL10^d, CXCL11^d	rs12079353 1:159,554,607	6.3×10^-11		unspecified application
445 Top	IL-17B R (cis) interleukin-17 receptor B	CACNA1D^a, DCP1A^b, CHDH^c, IL17RB^c	rs4453827 3:53,750,084	6.4×10^-11
446 Top	ART (cis) Agouti-related protein	SMPD3^a, TRADD^c, DUS2^c, ATP6V0D1^c	rs8051517 16:68,428,089	6.9×10^-11		unspecified application
447 Top	C4 (cis) Complement C4	MUC22^ac, VARS2^bc, MICB^bc, FLOT1^bc, MUC21^a [11 more]	rs1634718 6:30,972,865	7.4×10^-11
448 Top	TLR4:MD-2 complex (cis) Toll-like receptor 4:Lymphocyte antigen 96 complex	ASTN2^b	rs1159787 9:120,327,400	7.6×10^-11
449 Top	RANTES (cis) C-C motif chemokine 5	CCL5^abc, C17orf50^ae, RDM1^ae, LYZL6^ae, TAF15^a [3 more]MMP28^a, HEATR9^a, CCL23^b	rs4239252 17:34,163,565	7.8×10^-11		diagnosis, efficacy, unspecified application
450 Top	MED-1 (trans) Mediator of RNA polymerase II transcription subunit 1	PTCRA^abe, RPL7L1^ac, C6orf226^ac, GLTSCR1L^a, CNPY3^a [4 more]CUL9^b, PRPH2^b, PTK7^b, PEX6^c	rs9462846 6:42,861,581	8.1×10^-11
451 Top	Kallistatin (cis)		rs10135681 14:95,007,744	8.4×10^-11

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION