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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 124

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Siglec-9 cis Discovery rs1568003 19:51,633,660 C/T 0.40 995 0.530 0.043 4.4×10-32 2.860 8.1×10-32 2.7×10-35

 

Regional association plots

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Sialic acid-binding Ig-like lectin 9 (Siglec-9)

Target (abbrv.) Siglec-9
Target (full name) Sialic acid-binding Ig-like lectin 9
Somalogic ID (Sequence ID) SL005219 (3007-7_2)
Entrez Gene Symbol SIGLEC9
UniProt ID Q9Y336
UniProt Comment
  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Pathway Studio
  • Natural Killer Cell Inhibitory Receptor Signaling

All locus annotations are based on the sentinel SNP (rs1568003) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • SIGLEC9 sialic acid binding Ig-like lectin 9

 

Results from other genome-wide association studies

Trait P Study Source
cg14595786 (chr19:51626962) 2.4×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of OGFOD2 in peripheral blood monocytes 8.1×10-6 20502693 (PMID) GRASP2 eQTL