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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 132

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MMP-8 trans Discovery rs2736186 6:31,572,333 G/A 0.04 995 1.233 0.105 1.1×10-29 1.490 5.5×10-32 2.9×10-27

 

Regional association plots

 

Boxplots and histograms for top associations

Neutrophil collagenase (MMP-8)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Neutrophil collagenase (MMP-8)

Target (abbrv.) MMP-8
Target (full name) Neutrophil collagenase
Somalogic ID (Sequence ID) SL000526 (2954-56_2)
Entrez Gene Symbol MMP8
UniProt ID P22894
UniProt Comment
  • Can degrade fibrillar type I, II, and III collagens.
Targeted by drugs (based on IPA annotation)
  • marimastat
Biomarker applications (based on IPA annotation)
  • efficacy

All locus annotations are based on the sentinel SNP (rs2736186).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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eQTL genes

 

Results from other genome-wide association studies

Trait P Study Source
Transmission distortion 2.9×10-5 22377632 (PMID) GRASP2 nonQTL
Maternal transmission distortion 1.3×10-4 22377632 (PMID) GRASP2 nonQTL