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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 133

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Lysozyme cis Discovery rs1800973 12:69,744,014 C/A 0.07 995 0.953 0.082 2.4×10-29 1.140 1.2×10-28 8.8×10-31

 

Regional association plots

 

Boxplots and histograms for top associations

Lysozyme C (Lysozyme)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Lysozyme C (Lysozyme)

Target (abbrv.) Lysozyme
Target (full name) Lysozyme C
Somalogic ID (Sequence ID) SL000510 (4920-10_1)
Entrez Gene Symbol LYZ
UniProt ID P61626
UniProt Comment
  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Biomarker applications (based on IPA annotation)
  • unspecified application
Pathway Interaction Database
  • C-MYB transcription factor network
Reactome
  • Amyloids

All locus annotations are based on the sentinel SNP (rs1800973) and 1 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
Potentially regulated genes

 

Results from other genome-wide association studies

Trait P Study Source
Alcohol dependence 2.8×10-7 19581569 (PMID) GRASP2 nonQTL