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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 143

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-5 Ra cis Discovery rs2290610 3:3,139,957 T/C 0.36 994 0.489 0.043 7.6×10-28 1.170 2.3×10-27 7.8×10-22
IL-5 Ra cis Replication rs2290610 3:3,139,957 G/A 0.50 337 -0.344 0.064 1.8×10-7 -1.170 2.3×10-7 2.6×10-6

 

Regional association plots

Interleukin-5 receptor subunit alpha (IL-5 Ra)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Interleukin-5 receptor subunit alpha (IL-5 Ra)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-5 receptor subunit alpha (IL-5 Ra)

Target (abbrv.) IL-5 Ra
Target (full name) Interleukin-5 receptor subunit alpha
Somalogic ID (Sequence ID) SL005188 (4491-4_2)
Entrez Gene Symbol IL5RA
UniProt ID Q01344
UniProt Comment
  • This is the receptor for interleukin-5. The alpha chain binds to IL5.
Wiki Pathways
  • IL-3 Signaling Pathway
  • IL-5 signaling pathway
  • Inflammatory Response Pathway
Pathway Interaction Database
  • IL5-mediated signaling events
Reactome
  • G beta:gamma signalling through PI3Kgamma
  • GPVI-mediated activation cascade
  • Interleukin receptor SHC signaling
  • Interleukin-3, 5 and GM-CSF signaling
Pathway Studio
  • IL5R → SOX4 signaling
  • IL5R → STAT signaling

All locus annotations are based on the sentinel SNP (rs2290610) and 5 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (1-methylxanthine)/(homostachydrine*) 2.8×10-4 21886157 (PMID) GRASP2 metabQTL