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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 144

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
sFRP-3 cis Discovery rs288326 2:183,703,336 G/A 0.13 995 0.698 0.062 8.6×10-28 1.100 8×10-19 5.3×10-5
sFRP-3 cis Replication rs288326 2:183,703,336 G/A 0.07 337 0.897 0.125 5.4×10-12 1.220 3.7×10-11 3.2×10-9

 

Regional association plots

Secreted frizzled-related protein 3 (sFRP-3)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Secreted frizzled-related protein 3 (sFRP-3)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Secreted frizzled-related protein 3 (sFRP-3)

Target (abbrv.) sFRP-3
Target (full name) Secreted frizzled-related protein 3
Somalogic ID (Sequence ID) SL004650 (2841-13_2)
Entrez Gene Symbol FRZB
UniProt ID Q92765
UniProt Comment
  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Wiki Pathways
  • Adipogenesis
  • Endochondral Ossification

All locus annotations are based on the sentinel SNP (rs288326) and 1 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • FRZB frizzled-related protein

 

Results from other genome-wide association studies

Trait P Study Source
Height 3.6×10-5 25282103 (PMID) Supplemental file
Major depressive disorder (broad definition) 3.2×10-4 20038947 (PMID) GRASP2 nonQTL